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rpl13e rpl13e Smar_0290 Smar_0290 rpl35ae rpl35ae adk adk Smar_0401 Smar_0401 prf1 prf1 rps27e rps27e rpl44e rpl44e rpl10e rpl10e eif2a eif2a rpl40e rpl40e Smar_0715 Smar_0715 ef1b ef1b srp54 srp54 rpl21e rpl21e Smar_0790 Smar_0790 Smar_0802 Smar_0802 rpl30e rpl30e rps12 rps12 rps7 rps7 tuf tuf rps10 rps10 rps13 rps13 rps11 rps11 rpoD rpoD rpl18e rpl18e rpl13 rpl13 rps9 rps9 rps2 rps2 gltX gltX rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e ndk ndk infB infB rps6e rps6e eif2g eif2g rps24e rps24e rps15 rps15 rps3ae rps3ae rpl15e rpl15e rpl37ae rpl37ae Smar_0862 Smar_0862 Smar_0873 Smar_0873 pelA pelA map map Smar_0903 Smar_0903 rps17e rps17e Smar_0934 Smar_0934 Smar_0942 Smar_0942 Smar_0943 Smar_0943 rpl37e rpl37e rpl3 rpl3 rpl4 rpl4 rpl23 rpl23 rpl2 rpl2 rps19 rps19 rpl22 rpl22 rps3 rps3 rpl29 rpl29 rps17 rps17 rpl14 rpl14 rpl24 rpl24 rps4e rps4e rpl5 rpl5 rps14 rps14 rps8 rps8 rpl6 rpl6 rpl32e rpl32e rpl19e rpl19e rpl18 rpl18 rpl30 rpl30 rpl15 rpl15 rpl34e rpl34e rpl14e rpl14e Smar_1049 Smar_1049 rps19e rps19e rpl31e rpl31e eif6 eif6 rpl18a rpl18a ftsY ftsY rpl11 rpl11 rpl1 rpl1 rpl10 rpl10 eif2b eif2b eif1a eif1a eIF5A eIF5A Smar_1136 Smar_1136 proS proS Smar_1216 Smar_1216 rps8e rps8e srp19 srp19 Smar_1431 Smar_1431
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rpl13eKEGG: ape:APES024 50S ribosomal protein L13e; Belongs to the eukaryotic ribosomal protein eL13 family. (86 aa)
Smar_0290PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility C-terminal domain; KEGG: pho:PH0378 UDP-glucose 4-epimerase. (320 aa)
rpl35aeKEGG: ape:APE2324 50S ribosomal protein L35Ae; Belongs to the eukaryotic ribosomal protein eL33 family. (90 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (226 aa)
Smar_0401NMD3; PFAM: NMD3; KEGG: ape:APE2334 hypothetical protein. (241 aa)
prf1Peptide chain release factor subunit 1 (aeRF-1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (362 aa)
rps27ePFAM: Ribosomal protein S27E; KEGG: ape:APES015 30S ribosomal protein S27e. (69 aa)
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (95 aa)
rpl10eTIGRFAM: ribosomal protein L10.e; PFAM: Ribosomal protein L10E; KEGG: ape:APE0449 50S ribosomal protein L10e; Belongs to the universal ribosomal protein uL16 family. (174 aa)
eif2aTranslation initiation factor 2 subunit alpha (aeIF-2a); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (267 aa)
rpl40ePFAM: Ribosomal protein L40e; KEGG: ape:APES002 50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (53 aa)
Smar_0715PFAM: Protein of unknown function DUF1610; KEGG: sto:STS026 hypothetical protein. (73 aa)
ef1bTranslation elongation factor 1B (aEF-1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (90 aa)
srp54Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (441 aa)
rpl21ePFAM: ribosomal protein L21e; KEGG: sto:ST0459 50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (99 aa)
Smar_0790Ras superfamily GTP-binding protein YlqF; PFAM: GTP-binding protein, HSR1-related; KEGG: ape:APE0105 GTP-binding protein; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (266 aa)
Smar_0802DNA-directed RNA polymerase, subunit B' / DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1156 aa)
rpl30ePFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45; KEGG: pho:PHS043 50S ribosomal protein L30e; Belongs to the eukaryotic ribosomal protein eL30 family. (107 aa)
rps12SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
rps7SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (197 aa)
tufTranslation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (438 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (103 aa)
rps13SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (151 aa)
rps11SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (133 aa)
rpoDDNA-directed RNA polymerase, subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (280 aa)
rpl18ePFAM: ribosomal protein L15; KEGG: pab:PAB0364 50S ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family. (120 aa)
rpl13LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (150 aa)
rps9PFAM: ribosomal protein S9; KEGG: ape:APE1749 30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (137 aa)
rps2PFAM: ribosomal protein S2; KEGG: sso:SSO0067 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (220 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (566 aa)
rpl7aeLSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (128 aa)
rps28ePFAM: Ribosomal protein S28e; KEGG: ape:APES071 30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (89 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA. (62 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (141 aa)
infBTranslation initiation factor eaIF-5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (606 aa)
rps6ePFAM: ribosomal protein S6e; KEGG: sso:SSO0411 30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (216 aa)
eif2gTranslation initiation factor 2 subunit gamma (aeIF-2g); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (417 aa)
rps24ePFAM: Ribosomal protein S24e; KEGG: ape:APE1132 30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. (118 aa)
rps15PFAM: ribosomal protein S15; Ribosomal S13S15-like; KEGG: ape:APE1139 30S ribosomal protein S15. (154 aa)
rps3aePFAM: ribosomal protein S3Ae; KEGG: ape:APE1154 30S ribosomal protein S3Ae; Belongs to the eukaryotic ribosomal protein eS1 family. (212 aa)
rpl15ePFAM: Ribosomal protein L15e; KEGG: ape:APE1452 50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (220 aa)
rpl37aeLSU ribosomal protein L37AE; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. (87 aa)
Smar_0862Brix; Probably involved in the biogenesis of the ribosome. (180 aa)
Smar_0873KEGG: sai:Saci_1554 30S ribosomal protein S26E. (95 aa)
pelACell division protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (356 aa)
mapMethionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (301 aa)
Smar_0903ABC transporter related; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; ABC transporter related; Possible metal-binding region in RNase L inhibitor, RLI; SMART: AAA ATPase; KEGG: ape:APE1119 604aa long hypothetical RNase L inhibitor. (601 aa)
rps17eKEGG: ape:APES067 30S ribosomal protein S17e; Belongs to the eukaryotic ribosomal protein eS17 family. (68 aa)
Smar_0934TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Nucleolar GTP-binding 1; KEGG: pfu:PF1495 GTP-binding protein, gtp1/obg family. (354 aa)
Smar_0942PFAM: PUA domain containing protein; KEGG: mka:MK0219 PUA domain protein. (161 aa)
Smar_0943Small nuclear ribonucleoprotein, LSM family; PFAM: Like-Sm ribonucleoprotein, core; SMART: Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core; KEGG: sso:SSO6454 Small nuclear riboprotein protein (snRNP-2). (75 aa)
rpl37eLSU ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (62 aa)
rpl3LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (395 aa)
rpl4LSU ribosomal protein L4P; Forms part of the polypeptide exit tunnel. (271 aa)
rpl23LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (91 aa)
rpl2LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rps19SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (143 aa)
rpl22LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (157 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (224 aa)
rpl29PFAM: ribosomal protein L29; KEGG: sso:SSO6397 50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (67 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (117 aa)
rpl14LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (140 aa)
rpl24LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (152 aa)
rps4ePFAM: RNA-binding S4 domain protein; Ribosomal protein S4E-like; Ribosomal protein S4E, central; KEGG: ape:APE0356 30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (252 aa)
rpl5LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (188 aa)
rps14SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (54 aa)
rps8SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (185 aa)
rpl32ePFAM: Ribosomal protein L32e; KEGG: pab:PAB2133 50S ribosomal protein L32e; Belongs to the eukaryotic ribosomal protein eL32 family. (136 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (152 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (202 aa)
rpl30TIGRFAM: ribosomal protein L30P; PFAM: ribosomal protein L30; KEGG: ape:APE0345 50S ribosomal protein L30. (162 aa)
rpl15LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (152 aa)
rpl34ePFAM: Ribosomal protein L34e; KEGG: ape:APE0978a S ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (92 aa)
rpl14eKEGG: sai:Saci_0813 50S ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (96 aa)
Smar_1049PFAM: methyltransferase small; Methyltransferase type 11; Methyltransferase type 12; KEGG: sso:SSO0392 hypothetical protein. (193 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (165 aa)
rpl31eKEGG: ape:APE1087 50S ribosomal protein L31e; Belongs to the eukaryotic ribosomal protein eL31 family. (102 aa)
eif6Translation initiation factor 6 (aeIF-6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (227 aa)
rpl18aPFAM: Ribosomal LX protein; KEGG: ape:APE1084a S ribosomal protein LX. (87 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (295 aa)
rpl11LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (176 aa)
rpl1LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (215 aa)
rpl10LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (338 aa)
eif2bTranslation initiation factor 2 subunit beta (aeIF-2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa)
eif1aTranslation initiation factor 1A (aeIF-1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (111 aa)
eIF5ATranslation initiation factor 5A (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (131 aa)
Smar_1136PFAM: translation initiation factor SUI1; KEGG: ape:APE1629 translation factor SUI1; Belongs to the SUI1 family. (108 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (493 aa)
Smar_1216KEGG: sso:SSO0425 30S ribosomal protein S25e. (95 aa)
rps8eTIGRFAM: ribosomal protein S8e; PFAM: ribosomal protein S8E; KEGG: neq:NEQ469 SSU ribosomal protein S8E. (128 aa)
srp19Signal recognition particle, subunit SRP19 (srp19); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (95 aa)
Smar_1431Hypothetical protein. (171 aa)
Your Current Organism:
Staphylothermus marinus
NCBI taxonomy Id: 399550
Other names: S. marinus F1, Staphylothermus marinus ATCC 43588, Staphylothermus marinus DSM 3639, Staphylothermus marinus F1, Staphylothermus marinus JCM 9404, Staphylothermus marinus str. F1, Staphylothermus marinus strain F1
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