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| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (109 aa) |
| | SDH10371.1 | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (259 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa) |
| | SDH10259.1 | Glutamate synthase (NADH) large subunit. (1514 aa) |
| | SDH10235.1 | Glutamate synthase (NADH) small subunit. (484 aa) |
| | SDI02997.1 | Phosphoserine phosphatase. (217 aa) |
| | SDI02411.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (435 aa) |
| | SDI02342.1 | Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist. (328 aa) |
| | SDI01616.1 | Cystathionine gamma-synthase. (352 aa) |
| | SDI01390.1 | Dihydrofolate reductase. (219 aa) |
| | SDI01309.1 | Dihydrofolate reductase. (185 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (355 aa) |
| | SDI00119.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (461 aa) |
| | SDH99987.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (562 aa) |
| | SDH99221.1 | 3-methylcrotonyl-CoA carboxylase beta subunit. (535 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (410 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (266 aa) |
| | SDH98202.1 | Dihydrofolate synthase / folylpolyglutamate synthase. (525 aa) |
| | SDH98090.1 | 4-amino-4-deoxychorismate lyase. (283 aa) |
| | SDH97089.1 | Adenylyltransferase and sulfurtransferase. (371 aa) |
| | SDH95107.1 | Hypothetical protein. (316 aa) |
| | SDH93137.1 | O-acetylhomoserine sulfhydrylase. (435 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (398 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (436 aa) |
| | SDH92602.1 | Histidinol-phosphate phosphatase. (259 aa) |
| | SDH90045.1 | Succinyldiaminopimelate desuccinylase. (362 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (312 aa) |
| | SDH87994.1 | Shikimate kinase. (162 aa) |
| | leuD | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa) |
| | SDH87590.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (399 aa) |
| | SDH87447.1 | Dihydrofolate reductase. (189 aa) |
| | SDH87266.1 | Non-ribosomal peptide synthetase terminal domain of unknown function. (1288 aa) |
| | SDH86446.1 | Aldo/keto reductase. (294 aa) |
| | SDH85870.1 | RibD C-terminal domain-containing protein. (191 aa) |
| | SDH85677.1 | Branched chain amino acid aminotransferase apoenzyme. (365 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (348 aa) |
| | SDH85446.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (341 aa) |
| | SDH84949.1 | Acetolactate synthase, small subunit. (169 aa) |
| | SDH84919.1 | Acetolactate synthase, large subunit. (595 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (563 aa) |
| | SDH84290.1 | L-threonine ammonia-lyase. (415 aa) |
| | SDH84190.1 | FAD-linked oxidoreductase. (435 aa) |
| | SDH83089.1 | Gluconolactonase. (301 aa) |
| | SDH81206.1 | UDPglucose 6-dehydrogenase. (448 aa) |
| | SDH81108.1 | propionyl-CoA carboxylase beta chain. (527 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (352 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (347 aa) |
| | SDH77384.1 | Aspartate kinase; Belongs to the aspartokinase family. (423 aa) |
| | SDH76913.1 | Cystathionine gamma-lyase. (379 aa) |
| | SDH76886.1 | Cystathionine beta-synthase. (456 aa) |
| | SDH76555.1 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa) |
| | SDH76193.1 | NADPH:quinone reductase. (316 aa) |
| | SDH76097.1 | NADPH:quinone reductase. (316 aa) |
| | SDH75721.1 | Acyl dehydratase; Belongs to the UPF0336 family. (148 aa) |
| | SDH74058.1 | Glutamine synthetase. (454 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (280 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (420 aa) |
| | SDH70835.1 | NADPH:quinone reductase. (305 aa) |
| | SDH70808.1 | Prephenate dehydratase. (306 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (392 aa) |
| | SDH68464.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (438 aa) |
| | SDH63293.1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (560 aa) |
| | SDH63036.1 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. (362 aa) |
| | SDH61398.1 | NADPH:quinone reductase. (314 aa) |
| | SDH60953.1 | Agmatinase; Belongs to the arginase family. (319 aa) |
| | SDH60923.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (557 aa) |
| | SDH59426.1 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (252 aa) |
| | SDH59066.1 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (335 aa) |
| | SDH59032.1 | Glutamate carboxypeptidase. (384 aa) |
| | SDH57240.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa) |
| | SDH56050.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (310 aa) |
| | SDH54289.1 | Aldo/keto reductase. (277 aa) |
| | SDH54038.1 | Hippurate hydrolase. (413 aa) |
| | SDH52862.1 | NADPH:quinone reductase. (312 aa) |
| | SDH52608.1 | NADPH:quinone reductase. (322 aa) |
| | SDH51413.1 | Uncharacterized membrane protein YczE. (244 aa) |
| | SDH49368.1 | NADPH:quinone reductase. (325 aa) |
| | SDH48244.1 | NADPH:quinone reductase. (326 aa) |
| | SDH47006.1 | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa) |
| | SDH45348.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (400 aa) |
| | SDH43913.1 | Dihydrofolate reductase. (219 aa) |
| | SDH40105.1 | 5,10-methylenetetrahydrofolate dehydrogenase (NAD+). (304 aa) |
| | SDH39300.1 | Dihydroneopterin aldolase/dihydropteroate synthase,TIGR01496; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (391 aa) |
| | SDH39269.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. (168 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | SDH38109.1 | N-acetylglutamate synthase; Belongs to the acetyltransferase family. (166 aa) |
| | SDH35555.1 | Putative acetyltransferase. (153 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (119 aa) |
| | SDH33182.1 | tRNA threonylcarbamoyl adenosine modification protein YjeE. (302 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (476 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (425 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (287 aa) |
| | SDH29952.1 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa) |
| | SDH29852.1 | Aldo/keto reductase. (289 aa) |
| | SDH29445.1 | 2,5-diketo-D-gluconate reductase A. (271 aa) |
| | SDH29173.1 | 2,5-diketo-D-gluconate reductase A. (276 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (448 aa) |
| | SDH25415.1 | Homoserine dehydrogenase. (433 aa) |
| | SDH25383.1 | L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (356 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | SDH24843.1 | Serine O-acetyltransferase. (176 aa) |
| | SDH24816.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa) |
| | SDH24321.1 | Hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa) |
| | SDH23268.1 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (325 aa) |
| | SDH23116.1 | Carboxypeptidase PM20D1. (448 aa) |
| | SDH22680.1 | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (234 aa) |
| | SDH22599.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (176 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (282 aa) |
| | SDH22007.1 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. (302 aa) |
| | SDH21982.1 | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (750 aa) |
| | hisC | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (198 aa) |
| | SDH21850.1 | Imidazole glycerol phosphate synthase subunit hisH. (201 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (249 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (385 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (303 aa) |
| | SDH21369.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (307 aa) |
| | argH | Argininosuccinate lyase. (466 aa) |
| | SDH20692.1 | Prephenate dehydrogenase. (351 aa) |
| | SDH20315.1 | Amino acid adenylation domain-containing protein. (3460 aa) |
| | SDH18186.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Belongs to the class-II DAHP synthase family. (454 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa) |
| | SDH16918.1 | CysZ protein. (281 aa) |
| | SDH16718.1 | Phosphotransferase enzyme family protein. (400 aa) |
| | SDH16091.1 | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. (276 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (589 aa) |
| | SDH14132.1 | Acetylornithine deacetylase. (400 aa) |
| | SDH13941.1 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (331 aa) |
| | SDH13860.1 | [acyl-carrier-protein] S-malonyltransferase. (306 aa) |
| | SDH13697.1 | Homocysteine S-methyltransferase. (305 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (285 aa) |
| | SDH13135.1 | L-glutamine synthetase. (441 aa) |
| | SDH13018.1 | L-glutamine synthetase. (474 aa) |
| | SDH11165.1 | Shikimate dehydrogenase. (258 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (395 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (354 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | SDH10893.1 | Hypothetical protein. (165 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (374 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit. (1091 aa) |
| | SDH10562.1 | phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. (86 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (279 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | SDH10456.1 | Anthranilate synthase, component I. (506 aa) |
