STRINGSTRING
Pmen_3694 Pmen_3694 Pmen_3749 Pmen_3749 Pmen_3936 Pmen_3936 Pmen_4051 Pmen_4051 Pmen_4068 Pmen_4068 hutH hutH hutU hutU hutG hutG hutI hutI Pmen_4128 Pmen_4128 Pmen_4129 Pmen_4129 Pmen_4130 Pmen_4130 Pmen_4131 Pmen_4131 glyA-3 glyA-3 Pmen_4134 Pmen_4134 ilvA ilvA Pmen_4334 Pmen_4334 Pmen_4593 Pmen_4593 Pmen_1699 Pmen_1699 dtd dtd speA speA glyA glyA Pmen_0933 Pmen_0933 Pmen_1106 Pmen_1106 argF argF arcA arcA Pmen_1109 Pmen_1109 Pmen_1110 Pmen_1110 Pmen_1250 Pmen_1250 Pmen_1343 Pmen_1343 glyA-2 glyA-2 gcvP gcvP gcvH-2 gcvH-2 Pmen_1348 Pmen_1348 Pmen_1371 Pmen_1371 Pmen_1373 Pmen_1373 Pmen_1377 Pmen_1377 Pmen_1532 Pmen_1532 Pmen_0473 Pmen_0473 Pmen_0414 Pmen_0414 gcvH gcvH gcvT gcvT dadA dadA Pmen_0244 Pmen_0244 Pmen_0232 Pmen_0232 Pmen_0231 Pmen_0231 Pmen_0226 Pmen_0226 Pmen_1696 Pmen_1696 Pmen_1697 Pmen_1697 Pmen_0500 Pmen_0500 Pmen_1783 Pmen_1783 Pmen_1797 Pmen_1797 Pmen_2029 Pmen_2029 Pmen_2030 Pmen_2030 Pmen_2031 Pmen_2031 Pmen_2032 Pmen_2032 Pmen_2033 Pmen_2033 Pmen_2075 Pmen_2075 Pmen_2502 Pmen_2502 Pmen_2691 Pmen_2691 Pmen_2904 Pmen_2904 astE astE astB astB astD astD Pmen_2909 Pmen_2909 Pmen_2910 Pmen_2910 argD argD Pmen_2928 Pmen_2928 Pmen_3111 Pmen_3111 Pmen_3112 Pmen_3112 Pmen_3246 Pmen_3246 Pmen_3456 Pmen_3456 Pmen_3460 Pmen_3460 Pmen_3472 Pmen_3472 Pmen_3474 Pmen_3474 Pmen_3475 Pmen_3475 Pmen_3566 Pmen_3566 Pmen_3567 Pmen_3567
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pmen_3694TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase. (498 aa)
Pmen_3749PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (323 aa)
Pmen_3936PFAM: alanine racemase domain protein. (420 aa)
Pmen_4051Agmatinase; TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (320 aa)
Pmen_4068Transcriptional regulator, GntR family; TIGRFAM: histidine utilization repressor; PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein. (250 aa)
hutHTIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (511 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (553 aa)
hutGFormiminoglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (311 aa)
hutITIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (405 aa)
Pmen_4128TIGRFAM: sarcosine oxidase, gamma subunit family; PFAM: Sarcosine oxidase, gamma subunit. (209 aa)
Pmen_4129TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the GcvT family. (1005 aa)
Pmen_4130TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric. (108 aa)
Pmen_4131TIGRFAM: sarcosine oxidase, beta subunit family; PFAM: FAD dependent oxidoreductase. (416 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Pmen_4134L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
Pmen_4334PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain. (409 aa)
Pmen_4593TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase. (498 aa)
Pmen_1699TIGRFAM: maleylacetoacetate isomerase; PFAM: Glutathione S-transferase, N-terminal domain. (216 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa)
speAArginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (637 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Pmen_0933PFAM: Glutathione S-transferase, N-terminal domain. (210 aa)
Pmen_1106TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (308 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa)
arcATIGRFAM: arginine deiminase; PFAM: amidinotransferase. (416 aa)
Pmen_1109Arginine:ornithine antiporter, APA family; TIGRFAM: arginine/ornithine antiporter; PFAM: amino acid permease-associated region; TC 2.A.3.2.3. (475 aa)
Pmen_1110L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1311 aa)
Pmen_1250Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (496 aa)
Pmen_1343TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel. (374 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
gcvPGlycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (950 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
Pmen_1348Putative PAS/PAC sensor protein; PFAM: sigma-54 factor, interaction domain-containing protein; SMART: AAA ATPase. (506 aa)
Pmen_1371TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; Belongs to the HIBADH-related family. (294 aa)
Pmen_1373PFAM: Enoyl-CoA hydratase/isomerase. (367 aa)
Pmen_1377TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase. (498 aa)
Pmen_1532PFAM: histidine triad (HIT) protein. (145 aa)
Pmen_0473TIGRFAM: alanine dehydrogenase; PFAM: alanine dehydrogenase/PNT domain protein; Belongs to the AlaDH/PNT family. (373 aa)
Pmen_0414TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase. (498 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (365 aa)
dadAD-amino-acid dehydrogenase; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (432 aa)
Pmen_0244PFAM: regulatory protein, AsnC/Lrp family. (162 aa)
Pmen_0232TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase, class I and II; aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa)
Pmen_0231TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (483 aa)
Pmen_0226PFAM: Glutathione S-transferase, N-terminal domain. (201 aa)
Pmen_1696TIGRFAM: 4-hydroxyphenylpyruvate dioxygenase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (360 aa)
Pmen_1697PFAM: homogentisate 1,2-dioxygenase. (379 aa)
Pmen_0500PFAM: protein of unknown function DUF849. (294 aa)
Pmen_1783PFAM: histidine triad (HIT) protein. (148 aa)
Pmen_1797TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (319 aa)
Pmen_2029hydroxymethylglutaryl-CoA lyase; PFAM: pyruvate carboxyltransferase. (299 aa)
Pmen_20303-methylcrotonoyl-CoA carboxylase, alpha subunit; PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein. (644 aa)
Pmen_2031PFAM: Enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (266 aa)
Pmen_2032Propionyl-CoA carboxylase; PFAM: carboxyl transferase. (535 aa)
Pmen_2033PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain. (387 aa)
Pmen_2075PFAM: aminoglycoside phosphotransferase. (355 aa)
Pmen_25022-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (410 aa)
Pmen_2691Propionyl-CoA carboxylase; PFAM: carboxyl transferase. (538 aa)
Pmen_2904L-threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II. (334 aa)
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (337 aa)
astBSuccinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (448 aa)
astDSuccinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (487 aa)
Pmen_2909PFAM: arginine N-succinyltransferase beta subunit. (338 aa)
Pmen_2910PFAM: arginine N-succinyltransferase beta subunit. (338 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa)
Pmen_2928PFAM: NAD-glutamate dehydrogenase. (1613 aa)
Pmen_3111Transcriptional regulator, TyrR; PFAM: sigma-54 factor, interaction domain-containing protein; amino acid-binding ACT domain protein; SMART: PAS domain containing protein; AAA ATPase. (517 aa)
Pmen_3112TIGRFAM: phenylalanine-4-hydroxylase; PFAM: aromatic amino acid hydroxylase. (261 aa)
Pmen_3246PFAM: Transketolase, central region; Transketolase domain protein. (334 aa)
Pmen_3456PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family. (376 aa)
Pmen_3460PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family. (781 aa)
Pmen_3472PFAM: FAD dependent oxidoreductase. (413 aa)
Pmen_3474Aminomethyltransferase; PFAM: glycine cleavage T protein (aminomethyl transferase); FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family. (965 aa)
Pmen_3475Hypothetical protein. (192 aa)
Pmen_3566PFAM: ornithine cyclodeaminase/mu-crystallin. (319 aa)
Pmen_3567PFAM: FAD dependent oxidoreductase. (381 aa)
Your Current Organism:
Pseudomonas mendocina ymp
NCBI taxonomy Id: 399739
Other names: P. mendocina ymp, Pseudomonas mendocina str. ymp, Pseudomonas mendocina strain ymp
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.