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dapF dapF Spro_0406 Spro_0406 pyrI pyrI pyrB pyrB argI argI Spro_0683 Spro_0683 thrB thrB Spro_0685 Spro_0685 dapB dapB carA carA carB carB Spro_0880 Spro_0880 Spro_0881 Spro_0881 aroL aroL Spro_1222 Spro_1222 Spro_1467 Spro_1467 Spro_1549 Spro_1549 hisI hisI hisF hisF hisA hisA hisH hisH hisB hisB hisC hisC hisD hisD hisG hisG Spro_1624 Spro_1624 Spro_1705 Spro_1705 aroA aroA aroQ aroQ dapA dapA Spro_2415 Spro_2415 Spro_2667 Spro_2667 Spro_2668 Spro_2668 trpD trpD trpF trpF trpB trpB trpA trpA Spro_2723 Spro_2723 Spro_2808 Spro_2808 Spro_3187 Spro_3187 argI-2 argI-2 aroC aroC Spro_3409 Spro_3409 dapA-2 dapA-2 dapD dapD argA argA lysA lysA aroQ-2 aroQ-2 Spro_4479 Spro_4479 aroE aroE argD-2 argD-2 Spro_4583 Spro_4583 aroB aroB aroK aroK asd asd argH argH argG argG argB argB argC argC argE argE Spro_4785 Spro_4785 asnA asnA
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
Spro_0406TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. (478 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa)
pyrBKEGG: yen:YE3766 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
argIOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (339 aa)
Spro_0683Aspartate kinase; KEGG: yps:YPTB0602 bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal); TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. (819 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa)
Spro_0685KEGG: yps:YPTB0604 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (429 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: yen:YE0621 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (382 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: yen:YE0622 carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1074 aa)
Spro_0880TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: yen:YE0851 T-protein. (373 aa)
Spro_0881TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: yen:YE0852 P-protein. (385 aa)
aroLShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa)
Spro_1222TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: kpn:KPN_00695 asparagine synthetase B. (554 aa)
Spro_1467PFAM: glycosyl transferase family 3; KEGG: ypp:YPDSF_1932 glycosyl transferase. (319 aa)
Spro_1549PFAM: peptidase T2 asparaginase 2; KEGG: eca:ECA0132 L-asparaginase. (315 aa)
hisIPFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: yen:YE2772 histidine biosynthesis bifunctional protein [includes: phosphoribosyl-amp cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (204 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; histidine biosynthesis protein; KEGG: ypi:YpsIP31758_2433 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisBKEGG: yen:YE2768 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: yen:YE2767 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa)
Spro_1624TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: yen:YE1464 putative hydrolase. (218 aa)
Spro_1705TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; KEGG: sdy:SDY_3115 periplasmic L-asparaginase II; Belongs to the asparaginase 1 family. (348 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
Spro_2415PFAM: Pyrrolo-quinoline quinone; KEGG: atc:AGR_L_2936 probable quinate dehydrogenase. (811 aa)
Spro_2667KEGG: eca:ECA2296 anthranilate synthase component I; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like. (520 aa)
Spro_2668TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: yen:YE2210 anthranilate synthase component II. (193 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (332 aa)
trpFIndole-3-glycerol-phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Indole-3-glycerol phosphate synthase; KEGG: yen:YE2212 tryptophan biosynthesis protein TrpCF. (453 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
Spro_2723TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase/glutaminase; KEGG: yen:YE2261 L-asparaginase I. (338 aa)
Spro_2808TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: yps:YPTB1649 para-aminobenzoate synthase component I. (457 aa)
Spro_3187Carbamate kinase; KEGG: hip:CGSHiEE_09190 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (308 aa)
argI-2Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (312 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
Spro_3409TIGRFAM: aspartate racemase; PFAM: Asp/Glu racemase; KEGG: yen:YE1289 putative aspartate/glutamate racemase. (230 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
dapDTIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: ssn:SSON_0178 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa)
argATIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: yen:YE3308 amino-acid acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (441 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa)
aroQ-23-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
Spro_4479Aspartate kinase; KEGG: ypi:YpsIP31758_0301 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (455 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa)
argD-2Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
Spro_4583TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: yen:YE3958 para-aminobenzoate synthase glutamine amidotransferase component II. (191 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (366 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: yen:YE0121 putative argininosuccinate lyase. (457 aa)
argGPFAM: argininosuccinate synthase; KEGG: plu:plu4742 argininosuccinate synthase (citrulline-aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argEKEGG: ypi:YpsIP31758_0126 acetylornithine deacetylase (ArgE); TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein. (381 aa)
Spro_4785Aspartate kinase; KEGG: yen:YE0112 bifunctional aspartokinase/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa)
asnAPFAM: aspartate--ammonia ligase; KEGG: yen:YE0003 aspartate-ammonia ligase. (330 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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