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| | glmS | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | Spro_0037 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE4167 pyridoxal-phosphate dependent enzyme. (322 aa) |
| | dgoD | Mandelate racemase/muconate lactonizing protein; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa) |
| | glyQ | KEGG: ypi:YpsIP31758_4131 glycyl-tRNA synthetase, alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit. (304 aa) |
| | glyS | KEGG: ypi:YpsIP31758_4130 glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit. (689 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | Spro_0233 | Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: eca:ECA4336 putative aminotransferase. (395 aa) |
| | Spro_0241 | Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ypi:YpsIP31758_0262 transcriptional regulator MetR. (316 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa) |
| | Spro_0339 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pst:PSPTO_2960 pyridoxal-phosphate dependent enzyme family/ornithine cyclodeaminase family protein. (330 aa) |
| | Spro_0340 | PFAM: ornithine cyclodeaminase/mu-crystallin; KEGG: vei:Veis_1206 ornithine cyclodeaminase/mu-crystallin. (344 aa) |
| | Spro_0346 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: sus:Acid_4624 asparagine synthase (glutamine-hydrolyzing). (610 aa) |
| | Spro_0406 | TIGRFAM: aspartate ammonia-lyase; PFAM: fumarate lyase; KEGG: yen:YE0351 aspartate ammonia-lyase. (478 aa) |
| | Spro_0411 | KEGG: yen:YE0356 hypothetical protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. (342 aa) |
| | epmA | lysyl-tRNA synthetase-related protein GenX; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily. (325 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (156 aa) |
| | Spro_0509 | PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: yen:YE0455 ornithine decarboxylase, inducible. (723 aa) |
| | pyrB | KEGG: yen:YE3766 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa) |
| | argI | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (339 aa) |
| | Spro_0559 | PFAM: GCN5-related N-acetyltransferase; KEGG: ypp:YPDSF_3254 acetyltransferase. (177 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (958 aa) |
| | Spro_0584 | PFAM: glutamine synthetase catalytic region; KEGG: kpn:KPN_01021 putative glutamine synthetase. (465 aa) |
| | Spro_0606 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: aav:Aave_4746 methylmalonate-semialdehyde dehydrogenase. (502 aa) |
| | Spro_0640 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: ypi:YpsIP31758_2410 mandelate racemase/muconate lactonizing enzyme family protein. (425 aa) |
| | Spro_0666 | KEGG: yen:YE0578 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3. (325 aa) |
| | Spro_0683 | Aspartate kinase; KEGG: yps:YPTB0602 bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal); TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. (819 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | Spro_0685 | KEGG: yps:YPTB0604 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (429 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (938 aa) |
| | Spro_0707 | PFAM: dihydrodipicolinate synthetase; KEGG: vvy:VVA1582 putative dihydrodipicolinate synthase; Belongs to the DapA family. (300 aa) |
| | Spro_0708 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (570 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: yen:YE0621 carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (382 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: yen:YE0622 carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1074 aa) |
| | Spro_0720 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | Spro_0733 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. (97 aa) |
| | Spro_0734 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eca:ECA3848 acetolactate synthase isozyme I large subunit. (564 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | Spro_0748 | KEGG: yen:YE0658 acetolactate synthase isozyme III large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. (572 aa) |
| | Spro_0749 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: yen:YE0659 acetolactate synthase isozyme III small subunit. (163 aa) |
| | mtnN | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP [...] (233 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | Spro_0798 | KEGG: pfl:PFL_3514 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; Aluminium resistance family protein. (396 aa) |
| | Spro_0799 | KEGG: psb:Psyr_4832 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (507 aa) |
| | hutH | KEGG: yen:YE4094 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (511 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (593 aa) |
| | cysJ | Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (599 aa) |
| | cysI | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (571 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family. (892 aa) |
| | Spro_0879 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | Spro_0880 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: yen:YE0851 T-protein. (373 aa) |
| | Spro_0881 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: yen:YE0852 P-protein. (385 aa) |
| | Spro_0915 | PFAM: Asp/Glu racemase; KEGG: kpn:KPN_01788 putative hydantoin racemase. (247 aa) |
| | Spro_0941 | PFAM: aminotransferase class I and II; KEGG: eca:ECA3488 putative aminotransferase. (386 aa) |
| | mtnB | Class II aldolase/adducin family protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (206 aa) |
| | mtnC | 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (229 aa) |
| | mtnD | Acireductone dioxygenase ARD; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (180 aa) |
| | mtnA | eIF-2B alpha/beta/delta-related uncharacterized protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (342 aa) |
| | mtnK | 5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (399 aa) |
| | Spro_0951 | PFAM: glutamine amidotransferase class-II; KEGG: yps:YPTB0885 hypothetical protein. (268 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | Spro_0969 | PFAM: GCN5-related N-acetyltransferase; KEGG: stm:STM3653 putative acetyltransferase. (156 aa) |
| | Spro_0985 | PFAM: aldehyde dehydrogenase; KEGG: kpn:KPN_01455 phenylacetaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (499 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | Spro_1025 | PFAM: AroM family protein; KEGG: ssn:SSON_0366 protein of aro operon, regulated by AroR. (225 aa) |
| | Spro_1044 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (368 aa) |
| | Spro_1105 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE3124 putative pyridoxal-phosphate dependent protein. (347 aa) |
| | cysS | KEGG: ypi:YpsIP31758_3014 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (461 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (288 aa) |
| | leuS | TIGRFAM: leucyl-tRNA synthetase; KEGG: ypi:YpsIP31758_2926 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (860 aa) |
| | Spro_1222 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: kpn:KPN_00695 asparagine synthetase B. (554 aa) |
| | glnS | TIGRFAM: glutaminyl-tRNA synthetase; PFAM: glutamyl-tRNA synthetase class Ic; KEGG: yen:YE2977 glutaminyl-tRNA synthetase. (554 aa) |
| | Spro_1268 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (404 aa) |
| | Spro_1287 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | Spro_1336 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sco:SCO2696 2-hydroxyacid-family dehydrogenase. (319 aa) |
| | Spro_1379 | PFAM: GCN5-related N-acetyltransferase; KEGG: ngo:NGO1928 putative acetyltransferase. (153 aa) |
| | Spro_1406 | KEGG: aha:AHA_0049 tryptophanyl-tRNA synthetase; TIGRFAM: tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ib. (335 aa) |
| | Spro_1409 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecs:ECs5318 putative oxidoreductase. (337 aa) |
| | Spro_1432 | PFAM: Rhodanese domain protein; KEGG: yen:YE2868 putative sulfurtransferase. (281 aa) |
| | Spro_1467 | PFAM: glycosyl transferase family 3; KEGG: ypp:YPDSF_1932 glycosyl transferase. (319 aa) |
| | Spro_1516 | PFAM: ferredoxin-dependent glutamate synthase; KEGG: pap:PSPA7_1539 hypothetical protein. (540 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (675 aa) |
| | hisI | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: yen:YE2772 histidine biosynthesis bifunctional protein [includes: phosphoribosyl-amp cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (204 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; histidine biosynthesis protein; KEGG: ypi:YpsIP31758_2433 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisB | KEGG: yen:YE2768 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: yen:YE2767 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | Spro_1619 | TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: bmn:BMA10247_A0674 agmatinase; Belongs to the arginase family. (310 aa) |
| | Spro_1626 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1469 putative cystathionine gamma-synthase. (381 aa) |
| | Spro_1627 | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE1470 cystathionine beta-lyase. (455 aa) |
| | Spro_1636 | PFAM: purine or other phosphorylase family 1; KEGG: btl:BALH_2989 putative 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase. (279 aa) |
| | Spro_1638 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pfl:PFL_3440 serine/threonine dehydratase family protein. (322 aa) |
| | Spro_1663 | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1505 L-allo-threonine aldolase. (338 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | Spro_1705 | TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; KEGG: sdy:SDY_3115 periplasmic L-asparaginase II; Belongs to the asparaginase 1 family. (348 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | Spro_1729 | Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: yen:YE1561 aspartate aminotransferase. (401 aa) |
| | asnS | TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: yen:YE1564 asparaginyl-tRNA synthetase. (466 aa) |
| | Spro_1835 | PFAM: Malate/L-lactate dehydrogenase; KEGG: kpn:KPN_04791 putative dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family. (337 aa) |
| | Spro_1841 | PFAM: FAD dependent oxidoreductase; KEGG: plu:plu2242 hypothetical protein. (374 aa) |
| | Spro_1843 | PFAM: BFD domain protein [2Fe-2S]-binding domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bur:Bcep18194_B1891 pyridine nucleotide-disulphide oxidoreductase. (420 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa) |
| | Spro_1920 | PFAM: histidine triad (HIT) protein; KEGG: ypi:YpsIP31758_1588 histidine triad nucleotide-binding protein HinT. (116 aa) |
| | Spro_1999 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pol:Bpro_3215 pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (327 aa) |
| | Spro_2068 | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: ecs:ECs1874 putative glutamine synthetase. (472 aa) |
| | Spro_2076 | PFAM: N-formylglutamate amidohydrolase; KEGG: yen:YE2462 putative N-formylglutamate amidohydrolase. (267 aa) |
| | hutI | KEGG: yen:YE2461 imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (407 aa) |
| | Spro_2078 | Transcriptional regulator, histidine utilization repressor, GntR family; TIGRFAM: histidine utilization repressor; PFAM: regulatory protein GntR HTH; UbiC transcription regulator-associated domain protein; KEGG: yen:YE2460 putative GntR-family transcriptional regulatory protein. (251 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (642 aa) |
| | pheS | TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: ypi:YpsIP31758_1716 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (327 aa) |
| | pheT | KEGG: ypp:YPDSF_0722 phenylalanyl-tRNA synthetase beta chain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (795 aa) |
| | Spro_2172 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | sufS | Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (424 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | Spro_2396 | Dimethylargininase; PFAM: amidinotransferase; KEGG: yen:YE2045 putative hydrolase. (253 aa) |
| | Spro_2418 | PFAM: Pyridoxal-dependent decarboxylase; KEGG: eca:ECA2244 L-2,4-diaminobutyrate decarboxylase. (490 aa) |
| | Spro_2419 | TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: eca:ECA2243 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | Spro_2449 | PFAM: FAD dependent oxidoreductase; KEGG: pen:PSEEN3588 oxidase. (351 aa) |
| | Spro_2473 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: kpn:KPN_01492 putative glutamic dehyrogenase-like protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (424 aa) |
| | Spro_2493 | TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: azo:azo0369 probable cysteine desulphurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (605 aa) |
| | Spro_2495 | KEGG: mpt:Mpe_A0026 serine O-acetyltransferase. (256 aa) |
| | dsdA | KEGG: yen:YE0800 D-serine dehydratase; TIGRFAM: D-serine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (445 aa) |
| | Spro_2565 | PFAM: glutamine amidotransferase class-I; KEGG: cvi:CV_3746 glutamine amidotransferase. (238 aa) |
| | Spro_2615 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: yps:YPTB2260 putative mandelate racemase / muconate lactonizing protein. (326 aa) |
| | Spro_2667 | KEGG: eca:ECA2296 anthranilate synthase component I; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like. (520 aa) |
| | Spro_2668 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: yen:YE2210 anthranilate synthase component II. (193 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (332 aa) |
| | trpF | Indole-3-glycerol-phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Indole-3-glycerol phosphate synthase; KEGG: yen:YE2212 tryptophan biosynthesis protein TrpCF. (453 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | Spro_2696 | PFAM: FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: pfl:PFL_0501 oxidoreductase, FAD-binding. (465 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | Spro_2723 | TIGRFAM: L-asparaginase, type I; PFAM: Asparaginase/glutaminase; KEGG: yen:YE2261 L-asparaginase I. (338 aa) |
| | Spro_2745 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (357 aa) |
| | dadA | D-amino-acid dehydrogenase; Oxidative deamination of D-amino acids; Belongs to the DadA oxidoreductase family. (434 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (593 aa) |
| | argS | KEGG: ypp:YPDSF_1077 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. (576 aa) |
| | astE | Succinylglutamate desuccinylase/aspartoacylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (327 aa) |
| | astB | Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (446 aa) |
| | astD | Aldehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (490 aa) |
| | astA | Arginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. (344 aa) |
| | argD | Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa) |
| | Spro_2858 | Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE2470 putative GntR-family regulatory protein. (472 aa) |
| | Spro_2931 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1323 aa) |
| | dcyD | Pyridoxal phosphate-dependent enzyme, D-cysteine desulfhydrase family; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine; Belongs to the ACC deaminase/D-cysteine desulfhydrase family. (330 aa) |
| | kynA | Tryptophan 23-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (280 aa) |
| | Spro_3088 | Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: aha:AHA_0624 aromatic-amino-acid aminotransferase. (395 aa) |
| | Spro_3159 | PFAM: Threonyl/alanyl tRNA synthetase SAD; KEGG: pfo:Pfl_4187 metal-dependent hydrolase. (209 aa) |
| | Spro_3176 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: ent:Ent638_2113 methionine synthase, vitamin-B12 independent. (343 aa) |
| | Spro_3187 | Carbamate kinase; KEGG: hip:CGSHiEE_09190 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (308 aa) |
| | argI-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (312 aa) |
| | Spro_3216 | PFAM: glutamine synthetase catalytic region; KEGG: ecj:JW5201 gamma-Glu-putrescine synthase. (472 aa) |
| | Spro_3287 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecv:APECO1_2127 L-idonate 5-dehydrogenase. (344 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | Spro_3335 | PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; KEGG: ypi:YpsIP31758_1419 aspartate-semialdehyde dehydrogenase family protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (469 aa) |
| | Spro_3435 | PFAM: Ethanolamine ammonia-lyase light chain; KEGG: kpn:KPN_00306 ethanolamine ammonia-lyase small subunit; Belongs to the EutC family. (263 aa) |
| | Spro_3436 | PFAM: Ethanolamine ammonia lyase large subunit; KEGG: asa:ASA_0956 ethanolamine ammonia-lyase, large subunit. (461 aa) |
| | cysZ | Protein of unknown function DUF540; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (253 aa) |
| | Spro_3447 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yps:YPTB2714 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | Spro_3453 | TIGRFAM: cysteine synthase; cysteine synthase B; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ypi:YpsIP31758_1303 cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa) |
| | Spro_3471 | PFAM: homocysteine S-methyltransferase; KEGG: eca:ECA2797 homocysteine methyltransferase. (312 aa) |
| | Spro_3499 | PFAM: GCN5-related N-acetyltransferase; KEGG: cvi:CV_2792 probable acetyltransferase. (141 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | Spro_3560 | PFAM: protein of unknown function DUF1508; KEGG: ypi:YpsIP31758_1209 hypothetical protein. (112 aa) |
| | Spro_3563 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: eca:ECA0917 putative starvation sensing mandelate racemase / muconate lactonizing enzyme. (404 aa) |
| | Spro_3564 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: kpn:KPN_03621 putative dehydrogenase, NAD(P)-binding, starvation-sensing protein. (347 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | hisS | KEGG: yen:YE1074 histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein. (424 aa) |
| | Spro_3636 | PFAM: protein of unknown function DUF1355; KEGG: stm:STM1381 putative cytoplasmic protein. (247 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | patD | Aldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate via 4- aminobutanal. Also functions as a 5-aminopentanal dehydrogenase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. (474 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa) |
| | Spro_3677 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (545 aa) |
| | grcA | Formate C-acetyltransferase glycine radical; Acts as a radical domain for damaged PFL and possibly other radical proteins. (127 aa) |
| | Spro_3703 | PFAM: GCN5-related N-acetyltransferase; KEGG: eca:ECA1768 putative acetyltransferase. (150 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (572 aa) |
| | Spro_3767 | PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: kpn:KPN_00500 lysine decarboxylase 1. (713 aa) |
| | Spro_3773 | PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: yen:YE3267 lysine decarboxylase, constitutive. (714 aa) |
| | dapD | TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: ssn:SSON_0178 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | Spro_3807 | PFAM: aminotransferase class V; KEGG: kpn:KPN_03161 cysteine sulfinate desulfinase. (401 aa) |
| | argA | TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: yen:YE3308 amino-acid acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (441 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | Spro_3837 | Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE3333 transcriptional activator protein LysR. (307 aa) |
| | Spro_3869 | KEGG: vpa:VP1253 NifS-related protein; TIGRFAM: cysteine desulfurase family protein; PFAM: aminotransferase class V. (409 aa) |
| | lysS | TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: kpn:KPN_03318 lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (505 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (959 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (365 aa) |
| | Spro_3923 | PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: yen:YE3400 D-3-phosphoglycerate dehydrogenase. (412 aa) |
| | dlgD | Malate/L-lactate dehydrogenase; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa) |
| | Spro_3951 | TIGRFAM: export-related chaperone CsaA; PFAM: t-RNA-binding domain protein; KEGG: bcy:Bcer98_3652 export-related chaperone CsaA. (112 aa) |
| | Spro_3956 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: kpn:KPN_03360 putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (547 aa) |
| | speB | Putative agmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa) |
| | speA | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. (658 aa) |
| | gluQ | Glutamate--tRNA ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (303 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | glsA | PFAM: Glutaminase, core; KEGG: ypi:YpsIP31758_0822 glutaminase; Belongs to the glutaminase family. (307 aa) |
| | Spro_4047 | PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: ypp:YPDSF_0554 ornithine decarboxylase. (720 aa) |
| | Spro_4066 | KEGG: mlo:mll9370 hypothetical protein. (359 aa) |
| | Spro_4212 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: eca:ECA0354 cystathionine beta-lyase. (398 aa) |
| | Spro_4226 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ssn:SSON_2628 putative oxidoreductase. (352 aa) |
| | Spro_4306 | TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: kpn:KPN_03825 putative aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa) |
| | Spro_4317 | PFAM: glutamine amidotransferase class-I; KEGG: bpe:BP1437 glutamine amidotransferase. (243 aa) |
| | Spro_4344 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: yen:YE3735 glutamate synthase [NADPH] large chain precursor. (1486 aa) |
| | Spro_4345 | TIGRFAM: glutamate synthase, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ypi:YpsIP31758_0465 glutamate synthase, small subunit. (472 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | Spro_4426 | CTP synthase; KEGG: ent:Ent638_1664 CTP synthase. (232 aa) |
| | Spro_4445 | Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: yps:YPTB0377 aspartate aminotransferase. (397 aa) |
| | Spro_4448 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (359 aa) |
| | Spro_4479 | Aspartate kinase; KEGG: ypi:YpsIP31758_0301 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (455 aa) |
| | Spro_4490 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1209 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argD-2 | Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | Spro_4583 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: yen:YE3958 para-aminobenzoate synthase glutamine amidotransferase component II. (191 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (366 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | Spro_4624 | PFAM: Cupin 2 conserved barrel domain protein; KEGG: swi:Swit_3059 gentisate 1,2-dioxygenase. (344 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | Spro_4663 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: yen:YE4031 putative aldehyde dehydrogenase. (501 aa) |
| | Spro_4692 | Glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: yen:YE4051 NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (444 aa) |
| | Spro_4706 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: eca:ECA4382 putative zinc-binding dehydrogenase. (341 aa) |
| | Spro_4708 | PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: pol:Bpro_3962 mandelate racemase/muconate lactonizing enzyme. (358 aa) |
| | Spro_4733 | KEGG: bxe:Bxe_B2768 hypothetical protein. (215 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | ilvA | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvD | KEGG: eca:ECA4226 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa) |
| | Spro_4759 | KEGG: yen:YE0149 acetolactate synthase isozyme II small subunit. (85 aa) |
| | Spro_4760 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yen:YE0148 acetolactate synthase isozyme II large subunit. (548 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: yen:YE0121 putative argininosuccinate lyase. (457 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: plu:plu4742 argininosuccinate synthase (citrulline-aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argE | KEGG: ypi:YpsIP31758_0126 acetylornithine deacetylase (ArgE); TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein. (381 aa) |
| | Spro_4784 | KEGG: yen:YE0114 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa) |
| | Spro_4785 | Aspartate kinase; KEGG: yen:YE0112 bifunctional aspartokinase/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa) |
| | Spro_4786 | O-succinylhomoserine (thiol)-lyase; KEGG: ypi:YpsIP31758_0121 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa) |
| | metJ | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family. (105 aa) |
| | Spro_4814 | KEGG: yen:YE0082 serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; serine acetyltransferase domain protein. (273 aa) |
| | Spro_4822 | PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: sdy:SDY_4094 biodegradative arginine decarboxylase. (761 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | Spro_4881 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: yen:YE0027 glutamine synthetase. (469 aa) |
| | asnA | PFAM: aspartate--ammonia ligase; KEGG: yen:YE0003 aspartate-ammonia ligase. (330 aa) |
