STRINGSTRING
Spro_4837 Spro_4837 Spro_0131 Spro_0131 wecA wecA wzzE wzzE Spro_1585 Spro_1585 Spro_1590 Spro_1590 Spro_1591 Spro_1591 Spro_1592 Spro_1592 wecA-2 wecA-2 Spro_1603 Spro_1603 Spro_1604 Spro_1604 Spro_1606 Spro_1606 kdsB kdsB Spro_1774 Spro_1774 Spro_1775 Spro_1775 Spro_1859 Spro_1859 lpxL lpxL kdsA kdsA arnB arnB arnC arnC arnA arnA arnD arnD arnT arnT arnE arnE arnF arnF Spro_2204 Spro_2204 Spro_2268 Spro_2268 lpxM lpxM Spro_2893 Spro_2893 wecA-3 wecA-3 Spro_2896 Spro_2896 Spro_3149 Spro_3149 Spro_3151 Spro_3151 lpxT lpxT Spro_3575 Spro_3575 Spro_3663 Spro_3663 Spro_3752 Spro_3752 Spro_4052 Spro_4052 Spro_4076 Spro_4076 Spro_4362 Spro_4362 Spro_4363 Spro_4363 lpxP lpxP Spro_4826 Spro_4826 Spro_4827 Spro_4827 Spro_4828 Spro_4828 Spro_4830 Spro_4830 Spro_4832 Spro_4832 Spro_4833 Spro_4833 Spro_4834 Spro_4834 Spro_4835 Spro_4835 Spro_4836 Spro_4836
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Spro_4837PFAM: glycosyl transferase family 2; KEGG: yen:YE0068 lipopolysaccharide core biosynthesis glycosyl transferase. (257 aa)
Spro_0131PFAM: sulfatase; KEGG: ypi:YpsIP31758_4081 phosphoethanolamine transferase. (564 aa)
wecAUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (360 aa)
wzzELipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (350 aa)
Spro_1585Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: kpn:KPN_02510 tyrosine autokinase. (724 aa)
Spro_1590PFAM: glycosyl transferase group 1; KEGG: bfr:BF3922 probable mannosyltransferase. (385 aa)
Spro_1591PFAM: polysaccharide biosynthesis protein; KEGG: fjo:Fjoh_2240 polysaccharide biosynthesis protein. (479 aa)
Spro_1592PFAM: glycosyl transferase group 1; KEGG: bha:BH3663 lipopolysaccharide biosynthesis. (346 aa)
wecA-2Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (345 aa)
Spro_1603PFAM: glycosyl transferase group 1; KEGG: sdy:SDY_PA04 RfpB. (382 aa)
Spro_1604PFAM: glycosyl transferase group 1; KEGG: asa:ASA_1456 glycosyltransferase. (362 aa)
Spro_1606PFAM: polysaccharide biosynthesis protein; KEGG: vfi:VF0170 flippase. (412 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa)
Spro_1774PFAM: O-antigen polymerase; KEGG: yen:YE1727 putative inner membrane protein. (418 aa)
Spro_1775TIGRFAM: lipopolysaccharide heptosyltransferase III, putative; PFAM: glycosyl transferase family 9; KEGG: ypp:YPDSF_3215 lipopolysaccharide core biosynthesis protein. (389 aa)
Spro_1859PFAM: sulfatase; KEGG: eca:ECA0044 hypothetical protein. (554 aa)
lpxLLipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa)
kdsATIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: ypi:YpsIP31758_2062 3-deoxy-8-phosphooctulonate synthase. (284 aa)
arnBDegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa)
arnCGlycosyl transferase family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (326 aa)
arnANAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
arnDPolysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (301 aa)
arnTGlycosyl transferase family 39; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (555 aa)
arnEConserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (115 aa)
arnFConserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (130 aa)
Spro_2204PFAM: sulfatase; protein of unknown function DUF1705; KEGG: yen:YE2150 hypothetical protein. (545 aa)
Spro_2268PFAM: acyltransferase 3; KEGG: ret:RHE_CH00500 probable acyltransferase protein. (396 aa)
lpxMLipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa)
Spro_2893Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: eca:ECA1419 tyrosine-protein kinase. (727 aa)
wecA-3Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (349 aa)
Spro_2896PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: tde:TDE1439 epimerase/dehydratase, putative. (318 aa)
Spro_3149PFAM: glycosyl transferase family 9; KEGG: sfu:Sfum_0372 glycosyl transferase, family 9. (366 aa)
Spro_3151KEGG: sgl:SG2197 putative lipopolysaccharide glycosyltransferase. (302 aa)
lpxTPhosphoesterase PA-phosphatase related; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa)
Spro_3575KpsF/GutQ family protein; KEGG: yen:YE1092 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). (323 aa)
Spro_3663PFAM: sulfatase; KEGG: asu:Asuc_1041 sulfatase. (512 aa)
Spro_3752TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: ypi:YpsIP31758_1044 D,D-heptose 1,7-bisphosphate phosphatase. (201 aa)
Spro_4052KEGG: sec:SC041 hypothetical protein. (328 aa)
Spro_4076KEGG: kpn:KPN_01180 putative glycosyl transferase. (394 aa)
Spro_4362KpsF/GutQ family protein; KEGG: yen:YE3754 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). (328 aa)
Spro_43633-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (189 aa)
lpxPLipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa)
Spro_4826TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; KEGG: yen:YE0071 ADP-heptose--LPS heptosyltransferase II. (348 aa)
Spro_4827TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase family 9; KEGG: ypi:YpsIP31758_0068 lipopolysaccharide heptosyltransferase I. (323 aa)
Spro_4828KEGG: sgl:SG2197 putative lipopolysaccharide glycosyltransferase. (300 aa)
Spro_4830PFAM: glycosyl transferase family 9; KEGG: sfu:Sfum_0372 glycosyl transferase, family 9. (363 aa)
Spro_4832TIGRFAM: lipopolysaccharide heptosyltransferase III, putative; PFAM: glycosyl transferase family 9; KEGG: plu:plu4853 lipopolysaccharide core biosynthesis glycosyl transferase RfaQ. (360 aa)
Spro_4833PFAM: glycosyl transferase group 1; KEGG: kpn:KPN_03969 glucuronic acid transferase. (375 aa)
Spro_4834PFAM: glycosyl transferase group 1; KEGG: sgl:SG2200 putative lipopolysaccharide glycosyltransferase. (365 aa)
Spro_4835PFAM: glycosyl transferase family 9; KEGG: dar:Daro_0162 glycosyl transferase, family 9. (337 aa)
Spro_4836Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.