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| | anmK | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (373 aa) |
| | Spro_2204 | PFAM: sulfatase; protein of unknown function DUF1705; KEGG: yen:YE2150 hypothetical protein. (545 aa) |
| | Spro_2187 | KEGG: yen:YE2164 pyruvate kinase I; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (470 aa) |
| | Spro_2174 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | Spro_2173 | Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (292 aa) |
| | selO | Protein of unknown function UPF0061; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (480 aa) |
| | lplA | Lipoyltransferase and lipoate-protein ligase; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. (337 aa) |
| | arnC | Glycosyl transferase family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (326 aa) |
| | Spro_2128 | Fructosamine kinase; PFAM: aminoglycoside phosphotransferase; fructosamine kinase; KEGG: yen:YE1896 hypothetical protein. (289 aa) |
| | Spro_2040 | PFAM: DNA polymerase II beta subunit; KEGG: plu:plu2690 DNA polymerase III, theta subunit. (86 aa) |
| | Spro_2012 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PhoQ Sensor domain protein; KEGG: yen:YE1717 sensor protein kinase. (485 aa) |
| | Spro_2008 | TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: kpn:KPN_04015 phosphotransferase system PTS. (519 aa) |
| | nagK | ROK family protein; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (306 aa) |
| | Spro_1993 | KEGG: yen:YE2428 hypothetical protein. (269 aa) |
| | Spro_1997 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: yen:YE2425 putative inner membrane protein. (366 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (288 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | Spro_1959 | Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; KEGG: yen:YE2505 two-component system, sensor kinase. (533 aa) |
| | Spro_1941 | PFAM: DNA polymerase II beta subunit; KEGG: eca:ECA2475 DNA polymerase III, theta subunit. (76 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (289 aa) |
| | Spro_1914 | TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE1643 PTS system, glucose-specific IIBC component. (477 aa) |
| | Spro_1912 | KEGG: yps:YPTB2465 DNA polymerase III, delta' subunit; TIGRFAM: DNA polymerase III, delta prime subunit; PFAM: DNA polymerase III delta subunit. (335 aa) |
| | tmk | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | Spro_1859 | PFAM: sulfatase; KEGG: eca:ECA0044 hypothetical protein. (554 aa) |
| | Spro_1858 | PTS system, lactose/cellobiose family IIC subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa) |
| | Spro_1855 | PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: plu:plu2754 PTS system, cellobiose-specific IIB component. (101 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | Spro_1834 | PFAM: UspA domain protein; KEGG: eca:ECA1769 hypothetical protein. (142 aa) |
| | Spro_1733 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sun:SUN_1205 signal transduction response regulator. (568 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa) |
| | Spro_1718 | PFAM: protein of unknown function DUF343; KEGG: ypi:YpsIP31758_2572 hypothetical protein; Belongs to the UPF0434 family. (60 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (326 aa) |
| | cmk | Cytidylate kinase; KEGG: ypi:YpsIP31758_2581 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region. (229 aa) |
| | wecA-2 | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (345 aa) |
| | Spro_1599 | KEGG: eca:ECA1438 mannose-1-phosphate guanylyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. (474 aa) |
| | Spro_1585 | Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: kpn:KPN_02510 tyrosine autokinase. (724 aa) |
| | Spro_1582 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: yen:YE2777 UTP-glucose-1-phosphate uridylyltransferase. (297 aa) |
| | Spro_1581 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: yen:YE2778 UTP-glucose-1-phosphate uridylyltransferase. (304 aa) |
| | udk | TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: yen:YE2783 uridine kinase. (213 aa) |
| | Spro_1507 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: pol:Bpro_0544 periplasmic sensor signal transduction histidine kinase. (488 aa) |
| | Spro_1499 | Heavy metal sensor signal transduction histidine kinase; Member of a two-component regulatory system. (474 aa) |
| | Spro_1491 | PFAM: type III effector Hrp-dependent outers; KEGG: eca:ECA4328 hypothetical protein. (420 aa) |
| | Spro_1421 | KEGG: ent:Ent638_1988 putative substrate-binding periplasmic transport protein. (422 aa) |
| | Spro_1386 | PFAM: protein of unknown function RIO1; KEGG: yen:YE1747 hypothetical protein. (282 aa) |
| | lsrK | Carbohydrate kinase FGGY; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (521 aa) |
| | Spro_1362 | PFAM: transferase hexapeptide repeat containing protein; KEGG: kpn:KPN_04414 UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase. (156 aa) |
| | Spro_1319 | Protein of unknown function UPF0052 and CofD; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (305 aa) |
| | Spro_1308 | PFAM: PEBP family protein; KEGG: kpn:KPN_00798 conserved protein, phosphatidylethanolamine-binding domain. (160 aa) |
| | Spro_1292 | KEGG: kpn:KPN_00772 galactose-1-phosphate uridylyltransferase; TIGRFAM: galactose-1-phosphate uridylyltransferase; PFAM: galactose-1-phosphate uridyl transferase domain protein. (350 aa) |
| | galK | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (383 aa) |
| | Spro_1285 | Hpt sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: extracellular solute-binding protein family 3; KEGG: pfo:Pfl_1864 Hpt sensor hybrid histidine kinase. (1070 aa) |
| | Spro_1245 | PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Osmosensitive K channel His kinase sensor; UspA domain protein; KEGG: yen:YE2963 two-component regulatory protein sensor kinase KdpD. (897 aa) |
| | Spro_1228 | TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, N-acetylglucosamine-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: sugar-specific permease EIIA 1 domain; phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: stm:STM0685 Sugar Specific PTS family, n-acetylglucosamine-specific enzyme IIABC. (648 aa) |
| | Spro_1205 | KEGG: yps:YPTB1101 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta. (344 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (220 aa) |
| | Spro_1193 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; MASE2 domain protein; KEGG: yen:YE3010 putative diguanylate cyclase/phosphodiesterase domain 1 protein. (353 aa) |
| | Spro_1181 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; MASE1 domain protein; KEGG: pen:PSEEN2260 diguanylate cyclase (GGDEF) domain. (482 aa) |
| | Spro_1144 | Inosine kinase; PFAM: PfkB domain protein; KEGG: yen:YE3069 inosine-guanosine kinase. (434 aa) |
| | Spro_1142 | PFAM: glycerate kinase; KEGG: ypi:YpsIP31758_4052 glycerate kinase; Belongs to the glycerate kinase type-1 family. (382 aa) |
| | Spro_3847 | KEGG: plu:plu0835 PTS system, N-acetylgalactosamine-specific IIB component 2 (EIIB-AGA') (N-acetylgalactosamine-permease IIB component 2) (phosphotransferase enzyme II, B component 2); TIGRFAM: PTS system, mannose/fructose/sorbose family, IIB subunit; PFAM: PTS system sorbose subfamily IIB component. (158 aa) |
| | adk | Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa) |
| | dnaX | DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (650 aa) |
| | thiI | Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (327 aa) |
| | Spro_1066 | Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: yen:YE1614 tetrathionate reductase complex: sensory transduction histidine kinase. (585 aa) |
| | Spro_1042 | PAS/PAC sensor signal transduction histidine kinase; KEGG: yen:YE3181 phosphate regulon sensor protein PhoR; TIGRFAM: PAS sensor protein; Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (438 aa) |
| | Spro_1036 | PFAM: ROK family protein; KEGG: kpn:KPN_00337 possible NAGC-like transcriptional regulator. (302 aa) |
| | Spro_1034 | PFAM: PfkB domain protein; KEGG: yps:YPTB3802 PfkB family carbohydrate kinase. (337 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | dinB | DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (353 aa) |
| | mtnK | 5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (399 aa) |
| | dnaQ | DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (246 aa) |
| | Spro_0835 | PTS system, lactose/cellobiose family IIC subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa) |
| | Spro_0834 | TIGRFAM: PTS system, lactose/cellobiose family IIB subunit; PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: ypm:YP_2480 PTS system, cellobiose-specific IIB component. (126 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (235 aa) |
| | Spro_3848 | Tagatose-6-phosphate kinase; PFAM: D-tagatose-bisphosphate aldolase class II accessory protein AgaZ; KEGG: plu:plu0833 putative tagatose 6-phosphate kinase AgaZ. (427 aa) |
| | Spro_3881 | PFAM: P4 alpha zinc-binding domain protein; KEGG: eca:ECA2754 putative prophage primase. (929 aa) |
| | cysC | Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (209 aa) |
| | cysN | Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (481 aa) |
| | cysD | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: yen:YE0762 sulfate adenylyltransferase subunit 2. (302 aa) |
| | Spro_0792 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (743 aa) |
| | Spro_0790 | Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: ypm:YP_0304 two-component regulatory protein. (906 aa) |
| | Spro_3895 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE3383 putative histidine kinase sensor. (472 aa) |
| | Spro_3911 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: eba:ebA6233 sensor histidine kinase. (468 aa) |
| | Spro_3936 | PFAM: carbohydrate kinase FGGY; KEGG: eci:UTI89_C4124 cryptic L-xylulose kinase; Belongs to the FGGY kinase family. (493 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: yen:YE3414 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | pcnB | poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (505 aa) |
| | Spro_3988 | KEGG: ypi:YpsIP31758_3341 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (166 aa) |
| | Spro_3989 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: eca:ECA0007 two-component system sensor kinase. (452 aa) |
| | Spro_4019 | KEGG: pfo:Pfl_4167 hypothetical protein. (194 aa) |
| | Spro_4046 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: asa:ASA_3304 GGDEF domain protein. (370 aa) |
| | Spro_4054 | Histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sec:SC039 hypothetical protein. (547 aa) |
| | Spro_4064 | KEGG: stt:t4291 UV protection protein. (136 aa) |
| | Spro_4138 | KEGG: plt:Plut_0869 hypothetical protein. (325 aa) |
| | Spro_4203 | PFAM: PfkB domain protein; KEGG: yen:YE0554 fructokinase; Belongs to the carbohydrate kinase PfkB family. (309 aa) |
| | Spro_4205 | TIGRFAM: PTS system, sucrose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE0552 PTS system, sucrose-specific IIBC component. (456 aa) |
| | Spro_4223 | PTS system, lactose/cellobiose family IIC subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (439 aa) |
| | Spro_4224 | PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: eca:ECA4435 pts system, IIb component. (103 aa) |
| | Spro_4232 | PFAM: ROK family protein; KEGG: sdy:SDY_2740 putative NAGC-like transcriptional regulator. (400 aa) |
| | Spro_4270 | Dihydroxyacetone kinase, phosphotransfer subunit; KEGG: yen:YE0542 multifunctional PTS-system sugar transferase; TIGRFAM: phosphocarrier, HPr family; dihydroxyacetone kinase, phosphotransfer subunit; PFAM: phosphocarrier HPr protein; PTS system fructose subfamily IIA component; PEP-utilising protein mobile region; PEP-utilising protein domain protein; Belongs to the PEP-utilizing enzyme family. (477 aa) |
| | Spro_4271 | TIGRFAM: dihydroxyacetone kinase, L subunit; PFAM: Dak phosphatase; KEGG: yen:YE0541 hypothetical protein. (210 aa) |
| | Spro_4272 | Dihydroxyacetone kinase, DhaK subunit; KEGG: yen:YE0540 putative dihydroxyacetone kinase; TIGRFAM: dihydroxyacetone kinase, DhaK subunit; PFAM: Dak kinase. (356 aa) |
| | Spro_4280 | PFAM: PTS system sorbose subfamily IIB component; KEGG: aha:AHA_2341 PTS system mannose-specific EIIAB component (EIIAB-man). (164 aa) |
| | Spro_4281 | PFAM: PTS system fructose subfamily IIA component; KEGG: aha:AHA_2342 PTS system, mannose/fructose/sorbose family, IIA component. (142 aa) |
| | hldE | rfaE bifunctional protein; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (476 aa) |
| | glnE | (Glutamate--ammonia-ligase) adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal tra [...] (945 aa) |
| | cca | Polynucleotide adenylyltransferase/metal dependent phosphohydrolase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (414 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (582 aa) |
| | Spro_4342 | Multi-sensor hybrid histidine kinase; KEGG: ypi:YpsIP31758_0469 putative aerobic respiration control sensor protein ArcB; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (779 aa) |
| | Spro_4367 | RNA polymerase, sigma 54 subunit, RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (477 aa) |
| | Spro_4369 | TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: yen:YE3761 nitrogen regulatory IIA protein. (153 aa) |
| | Spro_4371 | TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein; KEGG: yen:YE3763 putative phosphocarrier protein. (90 aa) |
| | Spro_4372 | Transcriptional antiterminator, BglG; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; M trans-acting positive regulator; PRD domain protein; Helix-turn-helix type 11 domain protein; KEGG: yen:YE3777 putative transcriptional regulator. (638 aa) |
| | rnk | GreA/GreB family elongation factor; May act as an anti-Gre factor; Belongs to the Rnk family. (136 aa) |
| | Spro_4461 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | Spro_4479 | Aspartate kinase; KEGG: ypi:YpsIP31758_0301 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (455 aa) |
| | Spro_4497 | KEGG: stm:STM3542 gluconate kinase 2; TIGRFAM: carbohydrate kinase, thermoresistant glucokinase family; PFAM: shikimate kinase. (179 aa) |
| | aceK | (Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (584 aa) |
| | tsaC | SUA5/yciO/yrdC domain; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (189 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | slyX | PFAM: SlyX family protein; KEGG: ype:YPO0194 SlyX protein; Belongs to the SlyX family. (75 aa) |
| | Spro_4578 | PFAM: phosphoribulokinase/uridine kinase; KEGG: yen:YE3953 phosphoribulokinase 1. (289 aa) |
| | Spro_4588 | Signal transduction histidine kinase, LytS; PFAM: ATP-binding region ATPase domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type transmembrane region; SMART: GAF domain protein; KEGG: ecv:APECO1_4423 putative sensory kinase in two-component system with YehT. (561 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | Spro_4620 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE4005 osmolarity sensor protein. (459 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (425 aa) |
| | Spro_4650 | KEGG: sgl:SG2151 putative gluconokinase; TIGRFAM: carbohydrate kinase, thermoresistant glucokinase family; PFAM: shikimate kinase. (175 aa) |
| | Spro_4660 | PFAM: PfkB domain protein; KEGG: yen:YE4028 putative carbohydrate kinase. (642 aa) |
| | Spro_4697 | TIGRFAM: FGGY-family pentulose kinase; PFAM: carbohydrate kinase FGGY; KEGG: ypi:YpsIP31758_0368 pentulose kinase, FGGY family. (545 aa) |
| | Spro_4735 | Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sec:SC039 hypothetical protein. (594 aa) |
| | Spro_4750 | PFAM: PfkB domain protein; KEGG: ypi:YpsIP31758_4062 2-dehydro-3-deoxygluconokinase. (310 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | Spro_4785 | Aspartate kinase; KEGG: yen:YE0112 bifunctional aspartokinase/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (502 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | Spro_4811 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE0085 two component sensor kinase. (457 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa) |
| | Spro_4848 | PFAM: YicC domain protein; domain of unknown function DUF1732; KEGG: yen:YE0057 hypothetical protein. (287 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | rpoZ | DNA-directed RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (91 aa) |
| | Spro_4869 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa) |
| | Spro_4882 | Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: ypi:YpsIP31758_0026 nitrogen regulation protein NR(II). (349 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (934 aa) |
| | srkA | Aminoglycoside phosphotransferase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (328 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (197 aa) |
| | rbsK | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (318 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | Spro_0731 | KEGG: yen:YE0637 DNA polymerase II; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B. (787 aa) |
| | Spro_0697 | KEGG: ypi:YpsIP31758_3461 riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (312 aa) |
| | Spro_0689 | TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; KEGG: ecv:APECO1_1969 molybdopterin biosynthesis Mog protein. (195 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | Spro_0683 | Aspartate kinase; KEGG: yps:YPTB0602 bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal); TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. (819 aa) |
| | Spro_0673 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; histidine kinase HAMP region domain protein; KEGG: yen:YE0586 hypothetical protein. (415 aa) |
| | Spro_0668 | Transcriptional regulator, XRE family; TIGRFAM: cytidyltransferase-related domain; nicotinamide-nucleotide adenylyltransferase; PFAM: helix-turn-helix domain protein; KEGG: yps:YPTB0588 transcriptional regulator NadR. (419 aa) |
| | Spro_0650 | DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown. (145 aa) |
| | Spro_0645 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: yen:YE0557 HmsT protein. (357 aa) |
| | Spro_0576 | PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE1256 PTS transport protein. (480 aa) |
| | Spro_0570 | PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. (720 aa) |
| | Spro_0568 | KEGG: kpn:KPN_04693 hypothetical protein. (116 aa) |
| | Spro_0561 | PFAM: DNA polymerase III chi subunit HolC; KEGG: yen:YE0499 DNA polymerase III, chi subunit. (149 aa) |
| | Spro_0529 | TIGRFAM: PTS system, trehalose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE3774 PTS system, trehalose-specific IIBC component. (471 aa) |
| | phnN | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (189 aa) |
| | pnp | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (705 aa) |
| | Spro_0477 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE0422 two-component system sensor protein. (353 aa) |
| | rpoC | DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1408 aa) |
| | rpoB | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1342 aa) |
| | coaA | KEGG: ypi:YpsIP31758_3870 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase. (316 aa) |
| | ubiB | 2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (543 aa) |
| | Spro_0166 | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | wzzE | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (350 aa) |
| | wecA | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (360 aa) |
| | Spro_0133 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; MASE1 domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: ypi:YpsIP31758_4079 sensor histidine kinase UhpB. (513 aa) |
| | Spro_0131 | PFAM: sulfatase; KEGG: ypi:YpsIP31758_4081 phosphoethanolamine transferase. (564 aa) |
| | xylB | TIGRFAM: xylulokinase; PFAM: carbohydrate kinase FGGY; KEGG: yen:YE4123 xylulose kinase. (483 aa) |
| | Spro_0072 | TIGRFAM: PTS system, mannitol-specific IIC subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; phosphotransferase system EIIC; phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: yen:YE4148 PTS system, mannitol-specific IIABC component. (639 aa) |
| | Spro_0059 | PFAM: PfkB domain protein; KEGG: kpn:KPN_03913 putative kinase. (319 aa) |
| | Spro_0042 | 2-dehydro-3-deoxygalactonokinase; PFAM: 2-keto-3-deoxy-galactonokinase; KEGG: eca:ECA4418 2-dehydro-3-deoxygalactonokinase. (297 aa) |
| | Spro_0033 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (366 aa) |
| | Spro_0024 | KEGG: eca:ECA4463 hypothetical protein. (241 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | Spro_3775 | KEGG: ypi:YpsIP31758_1028 DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; PFAM: PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type; DNA polymerase III alpha subunit; SMART: phosphoesterase PHP domain protein. (1162 aa) |
| | Spro_3784 | PFAM: phosphatidate cytidylyltransferase; KEGG: yen:YE3278 phosphatidate cytidylyltransferase; Belongs to the CDS family. (282 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa) |
| | glnD | UTP-GlnB uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (892 aa) |
| | Spro_3823 | PTSINtr with GAF domain, PtsP; TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing protein; GAF domain protein; PEP-utilising protein mobile region; PEP-utilising protein domain protein; KEGG: yen:YE3319 phosphoenolpyruvate-protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. (748 aa) |
| | Spro_3844 | PFAM: PTS system fructose subfamily IIA component; KEGG: plu:plu0838 unnamed protein product; similar to putative PTS system IIA component YadI of Escherichia coli. (144 aa) |
| | Spro_3749 | PFAM: phospholipase D/Transphosphatidylase; KEGG: yen:YE3248 CDP-diacylglycerol--serine O-phosphatidyltransferase. (451 aa) |
| | Spro_3731 | Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; SMART: PAS domain containing protein; KEGG: eca:ECA2577 two-component sensor kinase. (532 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | Spro_3663 | PFAM: sulfatase; KEGG: asu:Asuc_1041 sulfatase. (512 aa) |
| | Spro_3660 | PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: ent:Ent638_3046 phosphotransferase system, EIIC. (455 aa) |
| | Spro_3653 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ypi:YpsIP31758_1150 putative sensor-like histidine kinase YfhK. (478 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | thiM | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (264 aa) |
| | Spro_3577 | KEGG: eca:ECA3196 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (266 aa) |
| | Spro_3571 | PFAM: PTS system glucitol/sorbitol-specific IIA component; KEGG: yen:YE1096 PTS system, glucitol/sorbitol-specific IIA component. (120 aa) |
| | Spro_3570 | KEGG: yen:YE1097 PTS system, glucitol/sorbitol-specific IIBC component; TIGRFAM: PTS system, glucitol/sorbitol-specific, IIBC subunit; PFAM: Sorbitol phosphotransferase protein II domain protein. (326 aa) |
| | Spro_3562 | Diacylglycerol kinase catalytic region; Probably phosphorylates lipids; the in vivo substrate is unknown. (305 aa) |
| | Spro_3556 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE1105 two-component system, sensor kinase. (460 aa) |
| | Spro_3550 | Kinase; KEGG: asa:ASA_4263 predicted kinase. (169 aa) |
| | Spro_3543 | Diguanylate cyclase/phosphodiesterase; PFAM: EAL domain protein; SMART: GGDEF domain containing protein; KEGG: kpn:KPN_02828 putative cytochrome c-type biogenesis protein. (750 aa) |
| | ppk | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (687 aa) |
| | Spro_3489 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: eca:ECA1900 nitrate/nitrite sensor protein. (560 aa) |
| | Spro_3451 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE1202 putative two-component system sensor kinase. (442 aa) |
| | Spro_3450 | TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease EIIA 1 domain; KEGG: yen:YE1205 PTS system, glucose-specific IIA component. (169 aa) |
| | Spro_3449 | Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa) |
| | Spro_3443 | KEGG: ypi:YpsIP31758_1322 hypothetical protein. (71 aa) |
| | Spro_3420 | TIGRFAM: 2,3-dihydroxybenzoate-AMP ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: kpn:KPN_00612 2,3-dihydroxybenzoate-AMP ligase. (542 aa) |
| | glk | Glucokinase; KEGG: ecv:APECO1_4149 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (320 aa) |
| | Spro_3404 | Signal transduction histidine kinase, LytS; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type transmembrane region; KEGG: yen:YE1228 two-component system histidine kinase. (563 aa) |
| | Spro_3339 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: plu:plu3178 two-component sensor kinase. (472 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | rcsC | Integral membrane sensor hybrid histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (957 aa) |
| | rcsD | Multi-sensor signal transduction histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (900 aa) |
| | lpxT | Phosphoesterase PA-phosphatase related; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa) |
| | Spro_3229 | 1-phosphofructokinase; PFAM: PfkB domain protein; KEGG: yen:YE1448 1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (313 aa) |
| | Spro_3228 | TIGRFAM: PTS system, fructose-specific, IIB subunnit; PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system EIIC; phosphotransferase system PTS fructose-specific IIB subunit; KEGG: yen:YE1449 PTS system, fructose-specific IIBC component. (561 aa) |
| | Spro_3223 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: rpa:RPA3076 putative diguanylate cyclase (GGDEF). (365 aa) |
| | Spro_3187 | Carbamate kinase; KEGG: hip:CGSHiEE_09190 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (308 aa) |
| | Spro_3167 | Holo-ACP synthase; PFAM: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; KEGG: yen:YE2649 putative apo-citrate lyase phosphoribosyl-dephospho-CoA transferase. (182 aa) |
| | citG | PFAM: triphosphoribosyl-dephospho-CoA protein; KEGG: sec:SC0648 putative modifier of citrate lyase protein. (294 aa) |
| | Spro_3163 | PFAM: 4'-phosphopantetheinyl transferase; KEGG: eca:ECA0474 enterobactin synthetase component D (4'-phosphopantetheinyl transferase); Belongs to the P-Pant transferase superfamily. (231 aa) |
| | Spro_3126 | Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase; PFAM: sulfatase; KEGG: ecp:ECP_4690 phosphoglycerol transferase I. (767 aa) |
| | Spro_3111 | KEGG: eca:ECA1481 hypothetical protein. (205 aa) |
| | glgS | Glycogen synthesis protein; Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides. (70 aa) |
| | Spro_3068 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: eca:ECA3148 putative regulator. (516 aa) |
| | Spro_3014 | SMART: tyrosine protein kinase; serine/threonine protein kinase; KEGG: azo:azo3888 putative serine/threonine kinase. (480 aa) |
| | Spro_2985 | CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; CheY binding; KEGG: yen:YE2577 chemotaxis protein CheA. (655 aa) |
| | fliA | RNA polymerase, sigma 28 subunit, FliA/WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (240 aa) |
| | Spro_2903 | PFAM: PEBP family protein; KEGG: reu:Reut_B3733 YbhB and YbcL. (188 aa) |
| | Spro_2899 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: eca:ECA2029 nitrate/nitrite sensor kinase. (594 aa) |
| | wecA-3 | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (349 aa) |
| | Spro_2893 | Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: eca:ECA1419 tyrosine-protein kinase. (727 aa) |
| | Spro_2813 | KEGG: yps:YPTB1634 PTS system, mannose-specific IIAB component; TIGRFAM: PTS system, mannose/fructose/sorbose family, IIB subunit; PTS system, mannose/fructose/sorbose family, IIA subunit; PFAM: PTS system fructose subfamily IIA component; PTS system sorbose subfamily IIB component. (323 aa) |
| | Spro_2799 | PFAM: ABC-1 domain protein; KEGG: sfr:Sfri_1807 ABC-1 domain protein. (546 aa) |
| | Spro_2770 | KEGG: eca:ECA2481 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (480 aa) |
| | Spro_2731 | PFAM: PrkA serine kinase; PrkA AAA domain protein; KEGG: yen:YE2272 hypothetical protein. (644 aa) |
| | selD | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | rssB | Response regulator receiver protein; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co- degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. (337 aa) |
| | Spro_2709 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: eca:ECA2329 UTP--glucose-1-phosphate uridylyltransferase. (305 aa) |
| | tdk | PFAM: thymidine kinase; KEGG: ypi:YpsIP31758_1964 thymidine kinase. (194 aa) |
| | Spro_2692 | PFAM: carbohydrate kinase FGGY; KEGG: pae:PA1487 probable carbohydrate kinase; Belongs to the FGGY kinase family. (480 aa) |
| | clsA | Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | Spro_2622 | TIGRFAM: shock protein C; PFAM: PspC domain protein; KEGG: yen:YE2119 phage shock protein C. (119 aa) |
| | Spro_2606 | DNA-directed DNA polymerase; PFAM: UMUC domain protein DNA-repair protein; KEGG: ecc:c1632 umuC protein; Belongs to the DNA polymerase type-Y family. (422 aa) |
| | Spro_2591 | Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ypi:YpsIP31758_1825 sensor protein RstB. (434 aa) |
| | Spro_2576 | PFAM: ROK family protein; KEGG: pin:Ping_1332 ROK family protein. (307 aa) |
| | Spro_2566 | TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: kpn:KPN_02766 pyridoxine kinase; Belongs to the pyridoxine kinase family. (279 aa) |
| | Spro_2560 | PFAM: protein of unknown function DUF344; KEGG: bur:Bcep18194_B1834 protein of unknown function DUF344. (304 aa) |
| | Spro_2518 | TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: pen:PSEEN2260 diguanylate cyclase (GGDEF) domain. (500 aa) |
| | Spro_2464 | PFAM: carbohydrate kinase FGGY; KEGG: ecv:APECO1_3757 putative sugar kinase YgcE. (481 aa) |
| | Spro_2414 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-4 domain protein; KEGG: acb:A1S_1949 putative diguanylate cyclase/phosphodiesterase. (697 aa) |
| | Spro_2323 | TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, beta-glucoside-specific IIABC subunit; PFAM: sugar-specific permease EIIA 1 domain; phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: eca:ECA0860 PTS system, IIabc component. (621 aa) |
| | Spro_2294 | PFAM: PfkB domain protein; KEGG: ret:RHE_CH03378 probable sugar kinase protein; Belongs to the carbohydrate kinase PfkB family. (317 aa) |
| | Spro_2270 | KEGG: yen:YE2011 PTS system, maltose and glucose-specific IIAbc component. (74 aa) |
| | Spro_2263 | TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, maltose and glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE2011 PTS system, maltose and glucose-specific IIAbc component. (474 aa) |
| | Spro_2258 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa) |
| | Spro_2257 | PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: kpn:KPN_04194 putative PTS family enzyme II component. (104 aa) |
| | Spro_2256 | PFAM: putative sugar-specific permease SgaT/UlaA; KEGG: kpn:KPN_04195 putative membrane protein, transport. (455 aa) |
| | Spro_2253 | Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: kpn:KPN_04197 putative PTS family enzyme IIA component. (145 aa) |
| | Spro_2252 | KEGG: kpn:KPN_04198 putative serine protease. (198 aa) |
| | araB | TIGRFAM: L-ribulokinase; PFAM: carbohydrate kinase FGGY; KEGG: ypp:YPDSF_0880 L-ribulokinase. (561 aa) |
| | Spro_2242 | KEGG: yen:YE1996 hypothetical protein. (146 aa) |
| | Spro_2227 | PFAM: aminoglycoside/hydroxyurea antibiotic resistance kinase; KEGG: pau:PA14_40450 streptomycin 3''-phosphotransferase. (284 aa) |
| | pdxY | Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (286 aa) |
