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| | Spro_0344 | PFAM: phosphoribosylglycinamide synthetase; KEGG: ypm:YP_3384 acetyl-CoA carboxylase. (424 aa) |
| | Spro_0042 | 2-dehydro-3-deoxygalactonokinase; PFAM: 2-keto-3-deoxy-galactonokinase; KEGG: eca:ECA4418 2-dehydro-3-deoxygalactonokinase. (297 aa) |
| | Spro_0043 | PFAM: KDPG and KHG aldolase; thiamine monophosphate synthase; KEGG: kpn:KPN_04096 putative keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase. (205 aa) |
| | dgoD | Mandelate racemase/muconate lactonizing protein; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa) |
| | Spro_0046 | KEGG: yen:YE4166 hypothetical protein. (426 aa) |
| | Spro_0085 | Formate dehydrogenase, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (299 aa) |
| | panZ | GCN5-related N-acetyltransferase; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family. (130 aa) |
| | fadA | acetyl-CoA C-acyltransferase FadA; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa) |
| | acs | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (652 aa) |
| | Spro_0342 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase. (579 aa) |
| | Spro_0411 | KEGG: yen:YE0356 hypothetical protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. (342 aa) |
| | Spro_0590 | KEGG: pap:PSPA7_3295 probable CoA transferase, subunit A; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase. (232 aa) |
| | Spro_0592 | KEGG: ppu:PP_4636 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | Spro_0593 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: kpn:KPN_02056 3-hydroxybutyryl-CoA dehydrogenase. (307 aa) |
| | Spro_0607 | PFAM: aminotransferase class-III; KEGG: pna:Pnap_4039 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | Spro_0625 | KEGG: plu:plu0990 hypothetical protein; TIGRFAM: 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1 subunit; PFAM: fumarylacetoacetate (FAA) hydrolase. (210 aa) |
| | Spro_0626 | KEGG: plu:plu0989 similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]; TIGRFAM: 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG2 subunit; PFAM: fumarylacetoacetate (FAA) hydrolase. (254 aa) |
| | Spro_0631 | KEGG: ssn:SSON_4494 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (HHED aldolase); TIGRFAM: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PFAM: HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (264 aa) |
| | Spro_0634 | TIGRFAM: 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit; PFAM: 4-hydroxyphenylacetate 3-hydroxylase; KEGG: stm:STM1099 4-hydroxyphenylacetate catabolism. (520 aa) |
| | Spro_0639 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ypi:YpsIP31758_2411 fumarylacetoacetate hydrolase family protein. (281 aa) |
| | Spro_0641 | PFAM: amidohydrolase 2; KEGG: bvi:Bcep1808_3379 amidohydrolase 2. (287 aa) |
| | gpmB | PFAM: Phosphoglycerate mutase; KEGG: plu:plu0559 phosphoglyceromutase 2; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (317 aa) |
| | Spro_0747 | PFAM: AMP-dependent synthetase and ligase; KEGG: ypi:YpsIP31758_3402 AMP binding protein. (602 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa) |
| | Spro_0799 | KEGG: psb:Psyr_4832 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (507 aa) |
| | hutH | KEGG: yen:YE4094 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase. (511 aa) |
| | hutU | Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (593 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (235 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | Spro_0888 | KEGG: yen:YE0896 hypothetical protein. (226 aa) |
| | Spro_0890 | KEGG: yen:YE0898 putative acyl carrier protein. (91 aa) |
| | acpP | Phosphopantetheine-binding; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (83 aa) |
| | Spro_0893 | KEGG: yen:YE0901 putative AMP-binding protein. (457 aa) |
| | Spro_0894 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: yen:YE0902 putative dehydratase. (114 aa) |
| | Spro_0900 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0908 putative beta-ketoacyl-[ACP] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (389 aa) |
| | Spro_0903 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0911 3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (409 aa) |
| | gloB | Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid. (251 aa) |
| | Spro_0949 | PFAM: acyl-CoA dehydrogenase domain protein; Protein of unknown function DUF1974; KEGG: yen:YE3224 probable acyl-CoA dehydrogenase. (818 aa) |
| | acpH | (Acyl-carrier-protein) phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa) |
| | Spro_1067 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: yen:YE1615 tetrathionate reductase subunit B. (244 aa) |
| | Spro_1083 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (303 aa) |
| | Spro_1101 | PFAM: thioesterase superfamily protein; KEGG: ent:Ent638_0910 thioesterase superfamily protein. (137 aa) |
| | Spro_1177 | KEGG: ent:Ent638_3518 beta-lactamase domain protein. (98 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | bioA | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (430 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (383 aa) |
| | bioC | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (255 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (226 aa) |
| | dld | D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (566 aa) |
| | Spro_1489 | PFAM: Xylose isomerase domain protein TIM barrel; KEGG: eca:ECA4330 putative isomerase; Belongs to the hyi family. (258 aa) |
| | maeA | Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: yen:YE2794 NAD-dependent malic enzyme; Belongs to the malic enzymes family. (565 aa) |
| | Spro_1608 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | Spro_1664 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yps:YPTB1384 pyruvate dehydrogenase; Belongs to the TPP enzyme family. (573 aa) |
| | Spro_1728 | PFAM: beta-lactamase domain protein; KEGG: ypi:YpsIP31758_2561 metallo-beta-lactamase family protein. (215 aa) |
| | Spro_1749 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (424 aa) |
| | fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | Spro_1831 | TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: csa:Csal_0301 beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | Spro_1832 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: pin:Ping_0657 3-hydroxybutyryl-CoA dehydrogenase. (509 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (344 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | Spro_1905 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: yen:YE1634 malonyl CoA-acyl carrier protein transacylase. (309 aa) |
| | Spro_1906 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | acpP-2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Spro_1908 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | fabV | Trans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (399 aa) |
| | Spro_1960 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: sme:SMb20498 hypothetical protein. (280 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (288 aa) |
| | Spro_2025 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: ypi:YpsIP31758_1615 isocitrate dehydrogenase, NADP-dependent. (417 aa) |
| | Spro_2048 | KEGG: yen:YE1725 isocitrate dehydrogenase. (50 aa) |
| | Spro_2074 | Chorismate mutase, putative; Catalyzes the Claisen rearrangement of chorismate to prephenate. (176 aa) |
| | hutI | KEGG: yen:YE2461 imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (407 aa) |
| | Spro_2090 | PFAM: protein of unknown function DUF453; KEGG: kpn:KPN_04047 hypothetical protein. (363 aa) |
| | Spro_2091 | TIGRFAM: 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase; PFAM: Dimethylmenaquinone methyltransferase; KEGG: ppf:Pput_3204 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase. (237 aa) |
| | Spro_2092 | PFAM: LmbE family protein; KEGG: ppf:Pput_1362 LmbE family protein. (247 aa) |
| | Spro_2095 | PFAM: amidohydrolase 2; KEGG: ppf:Pput_2198 amidohydrolase 2. (279 aa) |
| | Spro_2096 | Protocatechuate 4,5-dioxygenase; PFAM: Extradiol ring-cleavage dioxygenase class III protein subunit B; Extradiol ring-cleavage dioxygenase LigAB LigA subunit; KEGG: kpn:KPN_04051 2,3-dihydroxyphenylpropionate 1,2-dioxygenase. (420 aa) |
| | Spro_2174 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | Spro_2176 | PFAM: FAD linked oxidase domain protein; KEGG: yen:YE2174 hypothetical protein. (1018 aa) |
| | Spro_2187 | KEGG: yen:YE2164 pyruvate kinase I; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (470 aa) |
| | Spro_2200 | KEGG: yen:YE2153 lactoylglutathione lyase; TIGRFAM: lactoylglutathione lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase. (135 aa) |
| | anmK | Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (373 aa) |
| | Spro_2258 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa) |
| | bioD-2 | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. (223 aa) |
| | Spro_2290 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ypi:YpsIP31758_1864 oxidoreductase, short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | Spro_2303 | KEGG: vei:Veis_4629 fumarylacetoacetate (FAA) hydrolase. (334 aa) |
| | Spro_2365 | PFAM: MmgE/PrpD family protein; KEGG: eca:ECA3784 hypothetical protein. (439 aa) |
| | Spro_2385 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: asa:ASA_3149 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase. (151 aa) |
| | Spro_2419 | TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: eca:ECA2243 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | Spro_2424 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: kpn:KPN_02090 formate dehydrogenase H, selenopolypeptide subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (718 aa) |
| | Spro_2431 | PFAM: respiratory-chain NADH dehydrogenase subunit 1; KEGG: kpn:KPN_03059 hydrogenase 3, membrane subunit (part of FHL complex). (311 aa) |
| | Spro_2461 | Alkylglycerone-phosphate synthase; PFAM: FAD linked oxidase domain protein; KEGG: ecv:APECO1_3760 putative FAD containing dehydrogenase. (484 aa) |
| | Spro_2474 | PFAM: AMP-dependent synthetase and ligase; KEGG: rha:RHA1_ro03779 long-chain-fatty-acid--CoA ligase. (522 aa) |
| | Spro_2501 | TIGRFAM: protocatechuate 3,4-dioxygenase, beta subunit; PFAM: intradiol ring-cleavage dioxygenase; KEGG: kpn:KPN_01948 putative oxidoreductase. (242 aa) |
| | Spro_2506 | 4-hydroxybenzoate 3-monooxygenase; PFAM: monooxygenase FAD-binding; KEGG: rme:Rmet_5490 monooxygenase, FAD-binding. (392 aa) |
| | Spro_2678 | PFAM: thioesterase superfamily protein; KEGG: ypi:YpsIP31758_1945 thioesterase family protein. (142 aa) |
| | Spro_2728 | KEGG: ypi:YpsIP31758_1987 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | fadR | Fatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism. (239 aa) |
| | Spro_2753 | PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: yen:YE2366 putative fumarylacetoacetate hydrolase family protein. (218 aa) |
| | Spro_2760 | PFAM: AMP-dependent synthetase and ligase; KEGG: yen:YE2375 long-chain-fatty-acid-CoA ligase. (573 aa) |
| | Spro_2770 | KEGG: eca:ECA2481 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (480 aa) |
| | Spro_2866 | TIGRFAM: putative adenylate-forming enzyme; KEGG: ypi:YpsIP31758_2104 hypothetical protein. (427 aa) |
| | Spro_2869 | PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: yps:YPTB1971 putative 3-oxoacyl-(acyl-carrier-protein) synthase III. (335 aa) |
| | Spro_3023 | PFAM: MaoC domain protein dehydratase; KEGG: stp:Strop_0462 MaoC domain protein dehydratase. (171 aa) |
| | mhpE | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (333 aa) |
| | mhpF | Semialdehyde dehydrogenase NAD - binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (295 aa) |
| | Spro_3028 | PFAM: aminotransferase class I and II; KEGG: stp:Strop_0458 aminotransferase, class I and II. (407 aa) |
| | norW | FAD-dependent pyridine nucleotide-disulphide oxidoreductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase. (379 aa) |
| | Spro_3037 | KEGG: kpn:KPN_01538 acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase. (228 aa) |
| | Spro_3038 | KEGG: kpn:KPN_01539 acetyl-CoA:acetoacetyl-CoA transferase beta subunit; TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase. (226 aa) |
| | Spro_3039 | TIGRFAM: acetyl-CoA acetyltransferase; beta-ketoadipyl CoA thiolase; PFAM: Thiolase; KEGG: kpn:KPN_01540 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa) |
| | Spro_3056 | TIGRFAM: Quinone oxidoreductase putative PIG3; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ypi:YpsIP31758_1628 putative NAD(P)H quinone oxidoreductase, PIG3 family. (335 aa) |
| | Spro_3071 | TIGRFAM: phenylacetic acid degradation protein paaN; PFAM: aldehyde dehydrogenase; MaoC domain protein dehydratase; KEGG: kpn:KPN_01468 phenylacetic acid degradation protein; putative aldehyde dehydrogenase. (690 aa) |
| | Spro_3072 | TIGRFAM: phenylacetate-CoA oxygenase, PaaG subunit; PFAM: phenylacetic acid catabolic family protein; KEGG: kpn:KPN_01469 phenylacetic acid degradation protein. (312 aa) |
| | Spro_3073 | TIGRFAM: phenylacetate-CoA oxygenase, PaaH subunit; PFAM: phenylacetic acid degradation B; KEGG: kpn:KPN_01470 phenylacetic acid degradation protein. (96 aa) |
| | Spro_3074 | TIGRFAM: phenylacetate-CoA oxygenase, PaaI subunit; PFAM: phenylacetic acid catabolic family protein; KEGG: kpn:KPN_01471 phenylacetic acid degradation protein. (253 aa) |
| | Spro_3075 | TIGRFAM: phenylacetate-CoA oxygenase, PaaJ subunit; PFAM: protein of unknown function DUF59; KEGG: eco:b1391 phenylacetic acid degradation protein. (165 aa) |
| | Spro_3076 | TIGRFAM: phenylacetate-CoA oxygenase/reductase, PaaK subunit; PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: ecj:JW1387 predicted multicomponent oxygenase/reductase subunit for phenylacetic acid degradation. (352 aa) |
| | Spro_3078 | TIGRFAM: phenylacetate degradation probable enoyl-CoA hydratase paaB; PFAM: Enoyl-CoA hydratase/isomerase; KEGG: kpn:KPN_01475 enoyl-CoA hydratase. (263 aa) |
| | Spro_3079 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: kpn:KPN_01476 3-hydroxybutyryl-CoA dehydrogenase. (506 aa) |
| | Spro_3080 | TIGRFAM: phenylacetic acid degradation protein PaaD; PFAM: thioesterase superfamily protein; KEGG: ecj:JW1391 predicted thioesterase. (146 aa) |
| | Spro_3081 | KEGG: ecj:JW1392 predicted beta-ketoadipyl CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferase; beta-ketoadipyl CoA thiolase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | Spro_3082 | phenylacetate-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA). (436 aa) |
| | Spro_3083 | Transcriptional regulator, PaaX family; TIGRFAM: phenylacetic acid degradation operon negative regulatory protein PaaX; PFAM: PaaX domain protein; PaaX domain protein domain; KEGG: ecj:JW1394 DNA-binding transcriptional regulator, aryl-CoA responsive. (312 aa) |
| | Spro_3174 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (296 aa) |
| | uxuA | Mannonate dehydratase; Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family. (396 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (302 aa) |
| | Spro_3368 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE1287 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa) |
| | fadJ | Fatty acid oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (721 aa) |
| | fadI | acetyl-CoA C-acyltransferase FadI; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | glk | Glucokinase; KEGG: ecv:APECO1_4149 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (320 aa) |
| | Spro_3568 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: plu:plu2781 fructose-biphosphate aldolase class I (FBP aldolase). (349 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (373 aa) |
| | murQ | Glucokinase regulatory-like protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (297 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | Spro_3704 | PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: yen:YE1959 hypothetical protein. (244 aa) |
| | Spro_3729 | PFAM: beta-lactamase domain protein; KEGG: mpt:Mpe_A1376 methyl parathion hydrolase. (314 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (176 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa) |
| | aas | AMP-dependent synthetase and ligase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (717 aa) |
| | Spro_3840 | PFAM: beta-lactamase domain protein; KEGG: yps:YPTB3049 hypothetical protein. (294 aa) |
| | lldD | FMN-dependent alpha-hydroxy acid dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (380 aa) |
| | Spro_3865 | PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pmy:Pmen_4578 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | Spro_3905 | KEGG: bbr:BB2999 hypothetical protein. (237 aa) |
| | Spro_3912 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: swi:Swit_2294 alcohol dehydrogenase, zinc-binding domain protein. (322 aa) |
| | Spro_3944 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: yen:YE3414 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | Spro_3963 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: kpn:KPN_03366 putative ferredoxin reductase subunit. (403 aa) |
| | Spro_3969 | PFAM: Rieske [2Fe-2S] domain protein; KEGG: kpn:KPN_03371 putative ferredoxin. (105 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (286 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (284 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | Spro_4010 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (630 aa) |
| | Spro_4011 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | Spro_4068 | PFAM: protein of unknown function DUF201; KEGG: gka:GK2762 hypothetical protein. (413 aa) |
| | Spro_4069 | KEGG: bca:BCE_A0170 phosphoribosylglycinamide synthetase, ATP-grasp (A) domain protein. (389 aa) |
| | Spro_4276 | PFAM: glucose-6-phosphate isomerase; Cupin 2 conserved barrel domain protein; KEGG: aha:AHA_2345 glucose-6-phosphate isomerase. (187 aa) |
| | Spro_4277 | KEGG: pdi:BDI_3293 putative thermophilic glucose-6-phosphate isomerase-like protein. (260 aa) |
| | Spro_4306 | TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: kpn:KPN_03825 putative aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa) |
| | Spro_4309 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ypi:YpsIP31758_0501 2,4-dienoyl-coa reductase. (673 aa) |
| | uxaC | PFAM: Glucuronate isomerase; KEGG: yen:YE3708 uronate isomerase. (470 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | Spro_4417 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | Spro_4418 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (174 aa) |
| | pgi | PFAM: phosphoglucose isomerase (PGI); KEGG: yen:YE3870 glucose-6-phosphate isomerase; Belongs to the GPI family. (548 aa) |
| | edd | 6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (604 aa) |
| | aceK | (Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (584 aa) |
| | Spro_4503 | KEGG: ypi:YpsIP31758_0294 malate synthase A; TIGRFAM: malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family. (532 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | slyX | PFAM: SlyX family protein; KEGG: ype:YPO0194 SlyX protein; Belongs to the SlyX family. (75 aa) |
| | Spro_4576 | PFAM: alpha/beta hydrolase fold; KEGG: yen:YE3951 hypothetical protein. (326 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (232 aa) |
| | Spro_4625 | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: pna:Pnap_2474 5-carboxymethyl-2-hydroxymuconate delta-isomerase. (287 aa) |
| | bioH | bioH protein; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. (264 aa) |
| | Spro_4685 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: tte:TTE2131 NADH:flavin oxidoreductase, Old Yellow enzyme family. (587 aa) |
| | fabR | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (212 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | Spro_4843 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (405 aa) |
| | Spro_4857 | KEGG: mmr:Mmar10_2665 acetyl-CoA acetyltransferases; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | Spro_4859 | PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_A2076 long-chain-fatty-acid--CoA ligase. (512 aa) |
