STRINGSTRING
Spro_2392 Spro_2392 Spro_2411 Spro_2411 Spro_2420 Spro_2420 Spro_2540 Spro_2540 Spro_2625 Spro_2625 Spro_2833 Spro_2833 Spro_2944 Spro_2944 Spro_3083 Spro_3083 Spro_3104 Spro_3104 Spro_3109 Spro_3109 Spro_3837 Spro_3837 Spro_3896 Spro_3896 Spro_4021 Spro_4021 Spro_4131 Spro_4131 Spro_4214 Spro_4214 Spro_4236 Spro_4236 Spro_4269 Spro_4269 fis fis Spro_4446 Spro_4446 Spro_4681 Spro_4681 Spro_4687 Spro_4687 Spro_4732 Spro_4732 slmA slmA ntrC ntrC Spro_4906 Spro_4906 Spro_1462 Spro_1462 Spro_1439 Spro_1439 Spro_1385 Spro_1385 Spro_1244 Spro_1244 fur fur Spro_1176 Spro_1176 Spro_1106 Spro_1106 lon lon Spro_1028 Spro_1028 Spro_1019 Spro_1019 Spro_0984 Spro_0984 Spro_0837 Spro_0837 Spro_0679 Spro_0679 trpR trpR Spro_0633 Spro_0633 Spro_0597 Spro_0597 Spro_0596 Spro_0596 Spro_0578 Spro_0578 Spro_0313 Spro_0313 Spro_0152 Spro_0152 Spro_0102 Spro_0102 Spro_0094 Spro_0094 dnaA dnaA Spro_1682 Spro_1682 matP matP Spro_1839 Spro_1839 Spro_1876 Spro_1876 Spro_1931 Spro_1931 Spro_1523 Spro_1523 Spro_2013 Spro_2013 Spro_2046 Spro_2046 Spro_2238 Spro_2238 Spro_2248 Spro_2248 Spro_2337 Spro_2337 Spro_2400 Spro_2400 Spro_3120 Spro_3120 Spro_3217 Spro_3217 Spro_3337 Spro_3337 Spro_3482 Spro_3482 Spro_3514 Spro_3514 Spro_3547 Spro_3547 Spro_3557 Spro_3557 Spro_3590 Spro_3590 pepB pepB Spro_3712 Spro_3712
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Spro_2392PAS modulated sigma54 specific transcriptional regulator, Fis family; PFAM: sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; GAF domain protein; ATPase associated with various cellular activities AAA_5; SMART: PAS domain containing protein; AAA ATPase; KEGG: psp:PSPPH_2337 sigma-54 dependent transcriptional regulator. (652 aa)
Spro_2411GAF modulated sigma54 specific transcriptional regulator, Fis family; PFAM: sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; GAF domain protein; SMART: AAA ATPase; KEGG: kpn:KPN_02992 putative helix-turn-helix, fis-type. (595 aa)
Spro_2420Diguanylate cyclase with PAS/PAC sensor; KEGG: aha:AHA_3686 histidine kinase-response regulator hybrid protein; TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein. (624 aa)
Spro_2540Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: eca:ECA1518 AraC-family transcriptional regulator. (275 aa)
Spro_2625Sigma54 specific transcriptional regulator, Fis family; KEGG: yen:YE2122 psp operon transcriptional activator; TIGRFAM: Transcriptional activator PspF; PFAM: sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; SMART: AAA ATPase. (335 aa)
Spro_2833Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE1753 AraC-family transcriptional regulatory protein. (128 aa)
Spro_2944Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE2527 putative AraC-family transcriptional regulatory protein. (288 aa)
Spro_3083Transcriptional regulator, PaaX family; TIGRFAM: phenylacetic acid degradation operon negative regulatory protein PaaX; PFAM: PaaX domain protein; PaaX domain protein domain; KEGG: ecj:JW1394 DNA-binding transcriptional regulator, aryl-CoA responsive. (312 aa)
Spro_3104Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: cbe:Cbei_4446 transcriptional regulator, AraC family. (282 aa)
Spro_3109Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; ThiJ/PfpI domain protein; KEGG: bxe:Bxe_A0705 transcriptional regulator, AraC family. (320 aa)
Spro_3837Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE3333 transcriptional activator protein LysR. (307 aa)
Spro_3896Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: yps:YPTB3171 putative response regulator CreB family. (231 aa)
Spro_4021Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: sgl:SG0402 right origin-binding protein. (288 aa)
Spro_4131PFAM: ThiJ/PfpI domain protein; KEGG: plu:plu3545 hypothetical protein. (277 aa)
Spro_4214Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC-type transcriptional regulator domain protein; KEGG: yen:YE3649 AraC-family regulatory protein. (305 aa)
Spro_4236Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bte:BTH_I2369 transcriptional regulator, AraC family domain protein. (285 aa)
Spro_4269GAF modulated sigma54 specific transcriptional regulator, Fis family; PFAM: sigma-54 factor interaction domain-containing protein; helix-turn-helix Fis-type; GAF domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: yen:YE0550 glycerol metabolism operon regulatory protein. (648 aa)
fisTranscriptional regulator, Fis family; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (98 aa)
Spro_4446PFAM: regulatory protein AsnC/Lrp family; KEGG: eca:ECA3668 AsnC-family transcriptional regulator. (155 aa)
Spro_4681PFAM: regulatory protein AsnC/Lrp family; Helix-turn-helix type 11 domain protein; KEGG: aci:ACIAD1283 putative transcription regulator (AsnC family). (140 aa)
Spro_4687Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bte:BTH_I2369 transcriptional regulator, AraC family domain protein. (287 aa)
Spro_4732Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: atc:AGR_pAT_203 hypothetical protein. (257 aa)
slmATranscriptional regulator, TetR family; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. (198 aa)
ntrCNitrogen metabolism transcriptional regulator, NtrC, Fis Family; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (470 aa)
Spro_4906PFAM: regulatory protein AsnC/Lrp family; KEGG: yen:YE0002 regulatory protein. (153 aa)
Spro_1462PFAM: regulatory protein AsnC/Lrp family; KEGG: kpn:KPN_02209 putative regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system. (144 aa)
Spro_1439Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bld:BLi02818 hypothetical protein. (340 aa)
Spro_1385Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: psa:PST_2925 transcriptional regulator, AraC family. (272 aa)
Spro_1244Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: eca:ECA1338 two-component response regulator of kdp operon. (229 aa)
furFerric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: sgl:SG0861 ferric uptake regulation protein; Belongs to the Fur family. (148 aa)
Spro_1176Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bur:Bcep18194_B1198 transcriptional regulator, AraC family. (345 aa)
Spro_1106PFAM: regulatory protein AsnC/Lrp family; KEGG: yen:YE3123 probable AsnC-family regulatory protein. (153 aa)
lonATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (784 aa)
Spro_1028Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: ypi:YpsIP31758_4031 sensory box histidine kinase/response regulator. (870 aa)
Spro_1019Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bur:Bcep18194_B1773 transcriptional regulator, AraC family. (257 aa)
Spro_0984Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: kpn:KPN_01454 2-phenylethylamine catabolism regulatory protein. (302 aa)
Spro_0837Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; Cupin 2 conserved barrel domain protein; KEGG: yen:YE0971 cel operon repressor. (287 aa)
Spro_0679Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; transcription activator effector binding; KEGG: yen:YE0593 putative right origin-binding protein. (289 aa)
trpRTrp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. (109 aa)
Spro_0633Transcriptional regulator, AraC family; TIGRFAM: 4-hydroxyphenylacetate catabolism regulatory protein HpaA; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: kpn:KPN_04781 4-hydroxyphenylacetate catabolism. (298 aa)
Spro_0597Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; transcription activator effector binding; KEGG: yen:YE0593 putative right origin-binding protein. (292 aa)
Spro_0596Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: mmw:Mmwyl1_3814 helix-turn-helix-domain containing protein AraC type. (284 aa)
Spro_0578Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: mmw:Mmwyl1_0262 transcriptional regulator, AraC family. (255 aa)
Spro_0313Hypothetical protein; KEGG: ent:Ent638_1532 helix-turn-helix-domain containing protein, AraC type. (55 aa)
Spro_0152TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; histidine kinase HAMP region domain protein; KEGG: ypp:YPDSF_3363 membrane protein. (668 aa)
Spro_0102Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: ypi:YpsIP31758_4098 xylose operon regulatory protein. (392 aa)
Spro_0094Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; ThiJ/PfpI domain protein; KEGG: yen:YE4125 putative transcriptional regulator. (307 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (463 aa)
Spro_1682PFAM: regulatory protein AsnC/Lrp family; KEGG: plu:plu1600 leucine-responsive regulatory protein. (164 aa)
matPProtein of unknown function DUF1047; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain. (152 aa)
Spro_1839Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; PAS fold-4 domain protein; KEGG: plu:plu2244 hypothetical protein. (281 aa)
Spro_1876Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: ent:Ent638_3166 transcriptional regulator, AraC family. (253 aa)
Spro_1931Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: kpn:KPN_02968 putative helix-turn-helix, AraC type. (118 aa)
Spro_1523Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: sgl:SG0402 right origin-binding protein. (152 aa)
Spro_2013Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ypi:YpsIP31758_1608 transcriptional regulatory protein PhoP. (223 aa)
Spro_2046PFAM: regulatory protein AsnC/Lrp family; KEGG: ent:Ent638_0915 putative transcriptional regulator, AsnC family. (153 aa)
Spro_2238Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE1991 putative AraC-family transcriptional regulatory protein. (297 aa)
Spro_2248Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: yen:YE2006 arabinose operon regulatory protein. (305 aa)
Spro_2337Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE1743 putative AraC-family transcriptional regulatory protein. (289 aa)
Spro_2400PFAM: regulatory protein AsnC/Lrp family; KEGG: yen:YE2040 probable leucine-responsive regulatory protein. (151 aa)
Spro_3120Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; ThiJ/PfpI domain protein; KEGG: kpn:KPN_01709 putative helix-turn-helix, AraC type. (324 aa)
Spro_3217Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; KEGG: kpn:KPN_01019 putative oxidoreductase/putative regulator. (185 aa)
Spro_3337Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE1306 putative AraC-family regulatory protein. (257 aa)
Spro_3482Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: sgl:SG1549 putative right origin-binding protein. (140 aa)
Spro_3514PFAM: regulatory protein AsnC/Lrp family; Helix-turn-helix type 11 domain protein; KEGG: plu:plu4153 hypothetical protein. (153 aa)
Spro_3547PFAM: helix-turn-helix- domain containing protein AraC type; HhH-GPD family protein; Ada metal-binding domain protein; AlkA domain protein; KEGG: reh:H16_B2551 DNA-3-methyladenine glycosylase II, adenosine deaminase. (512 aa)
Spro_3557Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: yen:YE1104 two-component system response regulator. (239 aa)
Spro_3590Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: reh:H16_B0524 signal transduction histidine kinase containing a receiver domain (hybrid). (594 aa)
pepBPepB aminopeptidase; Probably plays an important role in intracellular peptide degradation. (431 aa)
Spro_3712Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE0935 AraC-family transcriptional regulator. (337 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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