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| | Spro_3575 | KpsF/GutQ family protein; KEGG: yen:YE1092 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). (323 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | Spro_0131 | PFAM: sulfatase; KEGG: ypi:YpsIP31758_4081 phosphoethanolamine transferase. (564 aa) |
| | wecA | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (360 aa) |
| | wzzE | Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family. (350 aa) |
| | fadA | acetyl-CoA C-acyltransferase FadA; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (387 aa) |
| | fadB | Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (729 aa) |
| | Spro_0342 | TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase. (579 aa) |
| | Spro_0344 | PFAM: phosphoribosylglycinamide synthetase; KEGG: ypm:YP_3384 acetyl-CoA carboxylase. (424 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (316 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (247 aa) |
| | Spro_0472 | PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (323 aa) |
| | Spro_0590 | KEGG: pap:PSPA7_3295 probable CoA transferase, subunit A; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase. (232 aa) |
| | Spro_0592 | KEGG: ppu:PP_4636 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | Spro_0593 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: kpn:KPN_02056 3-hydroxybutyryl-CoA dehydrogenase. (307 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (317 aa) |
| | Spro_0747 | PFAM: AMP-dependent synthetase and ligase; KEGG: ypi:YpsIP31758_3402 AMP binding protein. (602 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (354 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (321 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (235 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | Spro_0888 | KEGG: yen:YE0896 hypothetical protein. (226 aa) |
| | Spro_0889 | PFAM: phospholipid/glycerol acyltransferase; KEGG: yen:YE0897 putative acyltransferase. (272 aa) |
| | Spro_0890 | KEGG: yen:YE0898 putative acyl carrier protein. (91 aa) |
| | acpP | Phosphopantetheine-binding; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (83 aa) |
| | Spro_0894 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: yen:YE0902 putative dehydratase. (114 aa) |
| | Spro_0895 | PFAM: glycosyl transferase family 2; KEGG: yen:YE0903 putative bifunctional glycosyl transferase/acyl transferase. (572 aa) |
| | Spro_0900 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0908 putative beta-ketoacyl-[ACP] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (389 aa) |
| | Spro_0903 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0911 3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (409 aa) |
| | Spro_0949 | PFAM: acyl-CoA dehydrogenase domain protein; Protein of unknown function DUF1974; KEGG: yen:YE3224 probable acyl-CoA dehydrogenase. (818 aa) |
| | pagP | Antimicrobial peptide resistance and lipid A acylation PagP; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (197 aa) |
| | acpH | (Acyl-carrier-protein) phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family. (193 aa) |
| | Spro_1076 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (164 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | Spro_1079 | PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (306 aa) |
| | Spro_1101 | PFAM: thioesterase superfamily protein; KEGG: ent:Ent638_0910 thioesterase superfamily protein. (137 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa) |
| | Spro_1239 | PFAM: alpha/beta hydrolase fold; PGAP1 family protein; KEGG: yen:YE2969 hypothetical protein. (257 aa) |
| | Spro_1362 | PFAM: transferase hexapeptide repeat containing protein; KEGG: kpn:KPN_04414 UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase. (156 aa) |
| | Spro_1585 | Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: kpn:KPN_02510 tyrosine autokinase. (724 aa) |
| | Spro_1590 | PFAM: glycosyl transferase group 1; KEGG: bfr:BF3922 probable mannosyltransferase. (385 aa) |
| | Spro_1591 | PFAM: polysaccharide biosynthesis protein; KEGG: fjo:Fjoh_2240 polysaccharide biosynthesis protein. (479 aa) |
| | Spro_1592 | PFAM: glycosyl transferase group 1; KEGG: bha:BH3663 lipopolysaccharide biosynthesis. (346 aa) |
| | wecA-2 | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (345 aa) |
| | Spro_1603 | PFAM: glycosyl transferase group 1; KEGG: sdy:SDY_PA04 RfpB. (382 aa) |
| | Spro_1604 | PFAM: glycosyl transferase group 1; KEGG: asa:ASA_1456 glycosyltransferase. (362 aa) |
| | Spro_1606 | PFAM: polysaccharide biosynthesis protein; KEGG: vfi:VF0170 flippase. (412 aa) |
| | Spro_1624 | TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: yen:YE1464 putative hydrolase. (218 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (326 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (249 aa) |
| | Spro_1749 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (424 aa) |
| | fabA | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (172 aa) |
| | Spro_1774 | PFAM: O-antigen polymerase; KEGG: yen:YE1727 putative inner membrane protein. (418 aa) |
| | Spro_1775 | TIGRFAM: lipopolysaccharide heptosyltransferase III, putative; PFAM: glycosyl transferase family 9; KEGG: ypp:YPDSF_3215 lipopolysaccharide core biosynthesis protein. (389 aa) |
| | Spro_1831 | TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: csa:Csal_0301 beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | Spro_1832 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: pin:Ping_0657 3-hydroxybutyryl-CoA dehydrogenase. (509 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | Spro_1859 | PFAM: sulfatase; KEGG: eca:ECA0044 hypothetical protein. (554 aa) |
| | lpxL | Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (306 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (344 aa) |
| | fabH | 3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (317 aa) |
| | Spro_1905 | TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: yen:YE1634 malonyl CoA-acyl carrier protein transacylase. (309 aa) |
| | Spro_1906 | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | acpP-2 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Spro_1908 | Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | thiK | Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (289 aa) |
| | fabV | Trans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (399 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (288 aa) |
| | kdsA | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: ypi:YpsIP31758_2062 3-deoxy-8-phosphooctulonate synthase. (284 aa) |
| | Spro_2090 | PFAM: protein of unknown function DUF453; KEGG: kpn:KPN_04047 hypothetical protein. (363 aa) |
| | arnB | DegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa) |
| | arnC | Glycosyl transferase family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (326 aa) |
| | arnA | NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa) |
| | arnD | Polysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (301 aa) |
| | arnT | Glycosyl transferase family 39; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (555 aa) |
| | arnE | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (115 aa) |
| | arnF | Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (130 aa) |
| | Spro_2186 | PFAM: LPP repeat-containing protein; KEGG: yen:YE2165 major outer membrane lipoprotein. (78 aa) |
| | idi | Isopentenyl-diphosphate delta-isomerase, type 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (179 aa) |
| | Spro_2204 | PFAM: sulfatase; protein of unknown function DUF1705; KEGG: yen:YE2150 hypothetical protein. (545 aa) |
| | Spro_2268 | PFAM: acyltransferase 3; KEGG: ret:RHE_CH00500 probable acyltransferase protein. (396 aa) |
| | Spro_2290 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ypi:YpsIP31758_1864 oxidoreductase, short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | Spro_2352 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | Spro_2365 | PFAM: MmgE/PrpD family protein; KEGG: eca:ECA3784 hypothetical protein. (439 aa) |
| | Spro_2385 | PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: asa:ASA_3149 (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase. (151 aa) |
| | Spro_2474 | PFAM: AMP-dependent synthetase and ligase; KEGG: rha:RHA1_ro03779 long-chain-fatty-acid--CoA ligase. (522 aa) |
| | lapB | Tetratricopeptide TPR_2 repeat protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family. (389 aa) |
| | lapA | Protein of unknown function DUF1049; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family. (100 aa) |
| | Spro_2652 | Phosphatidylglycerophosphatase; PFAM: phosphoesterase PA-phosphatase related; KEGG: eca:ECA1944 phosphatidylglycerophosphatase B. (257 aa) |
| | Spro_2678 | PFAM: thioesterase superfamily protein; KEGG: ypi:YpsIP31758_1945 thioesterase family protein. (142 aa) |
| | clsA | Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | Spro_2711 | PFAM: Patatin; KEGG: yen:YE2244 hypothetical protein. (301 aa) |
| | fadR | Fatty acid metabolism transcriptional regulator FadR; Multifunctional regulator of fatty acid metabolism. (239 aa) |
| | Spro_2760 | PFAM: AMP-dependent synthetase and ligase; KEGG: yen:YE2375 long-chain-fatty-acid-CoA ligase. (573 aa) |
| | lpxM | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa) |
| | Spro_2865 | KEGG: eca:ECA0113 hypothetical protein. (206 aa) |
| | Spro_2869 | PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: yps:YPTB1971 putative 3-oxoacyl-(acyl-carrier-protein) synthase III. (335 aa) |
| | Spro_2893 | Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: eca:ECA1419 tyrosine-protein kinase. (727 aa) |
| | wecA-3 | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (349 aa) |
| | Spro_2896 | PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: tde:TDE1439 epimerase/dehydratase, putative. (318 aa) |
| | Spro_3037 | KEGG: kpn:KPN_01538 acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase. (228 aa) |
| | Spro_3038 | KEGG: kpn:KPN_01539 acetyl-CoA:acetoacetyl-CoA transferase beta subunit; TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase. (226 aa) |
| | Spro_3039 | TIGRFAM: acetyl-CoA acetyltransferase; beta-ketoadipyl CoA thiolase; PFAM: Thiolase; KEGG: kpn:KPN_01540 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa) |
| | Spro_3056 | TIGRFAM: Quinone oxidoreductase putative PIG3; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ypi:YpsIP31758_1628 putative NAD(P)H quinone oxidoreductase, PIG3 family. (335 aa) |
| | Spro_3078 | TIGRFAM: phenylacetate degradation probable enoyl-CoA hydratase paaB; PFAM: Enoyl-CoA hydratase/isomerase; KEGG: kpn:KPN_01475 enoyl-CoA hydratase. (263 aa) |
| | Spro_3079 | PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: kpn:KPN_01476 3-hydroxybutyryl-CoA dehydrogenase. (506 aa) |
| | Spro_3081 | KEGG: ecj:JW1392 predicted beta-ketoadipyl CoA thiolase; TIGRFAM: acetyl-CoA acetyltransferase; beta-ketoadipyl CoA thiolase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | Spro_3149 | PFAM: glycosyl transferase family 9; KEGG: sfu:Sfum_0372 glycosyl transferase, family 9. (366 aa) |
| | Spro_3151 | KEGG: sgl:SG2197 putative lipopolysaccharide glycosyltransferase. (302 aa) |
| | lpxT | Phosphoesterase PA-phosphatase related; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa) |
| | Spro_3318 | PFAM: NUDIX hydrolase; KEGG: eca:ECA3042 putative NUDIX hydrolase. (185 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (302 aa) |
| | Spro_3368 | PFAM: Beta-ketoacyl synthase; KEGG: yen:YE1287 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (404 aa) |
| | fadJ | Fatty acid oxidation complex, alpha subunit FadJ; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (721 aa) |
| | fadI | acetyl-CoA C-acyltransferase FadI; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (436 aa) |
| | Spro_3562 | Diacylglycerol kinase catalytic region; Probably phosphorylates lipids; the in vivo substrate is unknown. (305 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (373 aa) |
| | Spro_3630 | PFAM: inositol monophosphatase; KEGG: ypi:YpsIP31758_1165 inositol-1-monophosphatase. (267 aa) |
| | Spro_3659 | TIGRFAM: HAD superfamily (subfamily IF) hydrolase, YfhB; KEGG: ypi:YpsIP31758_1144 HAD hydrolase YfhB. (218 aa) |
| | Spro_3663 | PFAM: sulfatase; KEGG: asu:Asuc_1041 sulfatase. (512 aa) |
| | acpS | Holo-acyl-carrier-protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (126 aa) |
| | Spro_3749 | PFAM: phospholipase D/Transphosphatidylase; KEGG: yen:YE3248 CDP-diacylglycerol--serine O-phosphatidyltransferase. (451 aa) |
| | Spro_3752 | TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: ypi:YpsIP31758_1044 D,D-heptose 1,7-bisphosphate phosphatase. (201 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (176 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (340 aa) |
| | Spro_3784 | PFAM: phosphatidate cytidylyltransferase; KEGG: yen:YE3278 phosphatidate cytidylyltransferase; Belongs to the CDS family. (282 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa) |
| | aas | AMP-dependent synthetase and ligase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (717 aa) |
| | Spro_3865 | PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pmy:Pmen_4578 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | Spro_3912 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: swi:Swit_2294 alcohol dehydrogenase, zinc-binding domain protein. (322 aa) |
| | Spro_4052 | KEGG: sec:SC041 hypothetical protein. (328 aa) |
| | Spro_4068 | PFAM: protein of unknown function DUF201; KEGG: gka:GK2762 hypothetical protein. (413 aa) |
| | Spro_4069 | KEGG: bca:BCE_A0170 phosphoribosylglycinamide synthetase, ATP-grasp (A) domain protein. (389 aa) |
| | Spro_4076 | KEGG: kpn:KPN_01180 putative glycosyl transferase. (394 aa) |
| | Spro_4258 | KEGG: ypi:YpsIP31758_0582 1-acyl-sn-glycerol-3-phosphate acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (245 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (212 aa) |
| | Spro_4309 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ypi:YpsIP31758_0501 2,4-dienoyl-coa reductase. (673 aa) |
| | Spro_4341 | ThiJ/PfpI domain protein; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family. (217 aa) |
| | Spro_4362 | KpsF/GutQ family protein; KEGG: yen:YE3754 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS). (328 aa) |
| | Spro_4363 | 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (189 aa) |
| | Spro_4417 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | Spro_4418 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | lpxP | Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A); Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. (306 aa) |
| | Spro_4461 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (122 aa) |
| | plsB | Glycerol-3-phosphate O-acyltransferase; PFAM: phospholipid/glycerol acyltransferase; KEGG: yen:YE3857 glycerol-3-phosphate acyltransferase; Belongs to the GPAT/DAPAT family. (821 aa) |
| | Spro_4576 | PFAM: alpha/beta hydrolase fold; KEGG: yen:YE3951 hypothetical protein. (326 aa) |
| | Spro_4685 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: tte:TTE2131 NADH:flavin oxidoreductase, Old Yellow enzyme family. (587 aa) |
| | cdh | PFAM: CDP-diacylglycerol pyrophosphatase; KEGG: yen:YE4061 CDP-diacylglycerol pyrophosphatase. (265 aa) |
| | fabR | Transcriptional regulator, TetR family; Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer. (212 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: yen:YE0081 glycerol-3-phosphate dehydrogenase. (339 aa) |
| | Spro_4826 | TIGRFAM: lipopolysaccharide heptosyltransferase II; PFAM: glycosyl transferase family 9; KEGG: yen:YE0071 ADP-heptose--LPS heptosyltransferase II. (348 aa) |
| | Spro_4827 | TIGRFAM: lipopolysaccharide heptosyltransferase I; PFAM: glycosyl transferase family 9; KEGG: ypi:YpsIP31758_0068 lipopolysaccharide heptosyltransferase I. (323 aa) |
| | Spro_4828 | KEGG: sgl:SG2197 putative lipopolysaccharide glycosyltransferase. (300 aa) |
| | Spro_4830 | PFAM: glycosyl transferase family 9; KEGG: sfu:Sfum_0372 glycosyl transferase, family 9. (363 aa) |
| | Spro_4832 | TIGRFAM: lipopolysaccharide heptosyltransferase III, putative; PFAM: glycosyl transferase family 9; KEGG: plu:plu4853 lipopolysaccharide core biosynthesis glycosyl transferase RfaQ. (360 aa) |
| | Spro_4833 | PFAM: glycosyl transferase group 1; KEGG: kpn:KPN_03969 glucuronic acid transferase. (375 aa) |
| | Spro_4834 | PFAM: glycosyl transferase group 1; KEGG: sgl:SG2200 putative lipopolysaccharide glycosyltransferase. (365 aa) |
| | Spro_4835 | PFAM: glycosyl transferase family 9; KEGG: dar:Daro_0162 glycosyl transferase, family 9. (337 aa) |
| | Spro_4836 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa) |
| | Spro_4837 | PFAM: glycosyl transferase family 2; KEGG: yen:YE0068 lipopolysaccharide core biosynthesis glycosyl transferase. (257 aa) |
| | Spro_4857 | KEGG: mmr:Mmar10_2665 acetyl-CoA acetyltransferases; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | Spro_4859 | PFAM: AMP-dependent synthetase and ligase; KEGG: reh:H16_A2076 long-chain-fatty-acid--CoA ligase. (512 aa) |
