STRINGSTRING
Spro_4884 Spro_4884 Spro_0043 Spro_0043 Spro_0255 Spro_0255 Spro_0279 Spro_0279 thiG thiG thiE thiE Spro_0411 Spro_0411 Spro_0524 Spro_0524 deoC deoC tal tal Spro_0707 Spro_0707 leuA leuA guaC guaC Spro_0779 Spro_0779 queE queE Spro_0879 Spro_0879 Spro_1033 Spro_1033 Spro_1172 Spro_1172 lipA lipA Spro_1287 Spro_1287 bioB bioB moaA moaA dusC dusC Spro_1516 Spro_1516 hisF hisF hisA hisA deoC-2 deoC-2 Spro_1701 Spro_1701 pyrD pyrD Spro_1838 Spro_1838 leuA-2 leuA-2 Spro_1885 Spro_1885 Spro_1960 Spro_1960 kdsA kdsA Spro_2172 Spro_2172 Spro_2202 Spro_2202 dapA dapA Spro_2255 Spro_2255 Spro_2465 Spro_2465 Spro_2579 Spro_2579 Spro_2640 Spro_2640 Spro_2641 Spro_2641 pyrF pyrF trpF trpF trpA trpA Spro_2767 Spro_2767 mhpE mhpE Spro_3436 Spro_3436 tal-2 tal-2 dapA-2 dapA-2 Spro_3568 Spro_3568 guaB guaB rlmN rlmN pdxJ pdxJ Spro_3848 Spro_3848 lldD lldD Spro_3937 Spro_3937 Spro_3944 Spro_3944 Spro_4035 Spro_4035 Spro_4309 Spro_4309 Spro_4344 Spro_4344 Spro_4374 Spro_4374 dusB dusB dusA dusA Spro_4500 Spro_4500 Spro_4601 Spro_4601 Spro_4660 Spro_4660 Spro_4685 Spro_4685 tpiA tpiA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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Spro_4884KEGG: yen:YE0024 oxygen-independent coproporphyrinogen III oxidase; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; PFAM: Radical SAM domain protein; HemN domain protein; SMART: Elongator protein 3/MiaB/NifB; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (457 aa)
Spro_0043PFAM: KDPG and KHG aldolase; thiamine monophosphate synthase; KEGG: kpn:KPN_04096 putative keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase. (205 aa)
Spro_0255Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (340 aa)
Spro_0279TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; KEGG: ypi:YpsIP31758_3857 thiazole biosynthesis protein ThiH. (377 aa)
thiGThiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (259 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa)
Spro_0411KEGG: yen:YE0356 hypothetical protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. (342 aa)
Spro_0524Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa)
Spro_0707PFAM: dihydrodipicolinate synthetase; KEGG: vvy:VVA1582 putative dihydrodipicolinate synthase; Belongs to the DapA family. (300 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa)
guaCGuanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
Spro_0779KEGG: yen:YE0691 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (296 aa)
queERadical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (223 aa)
Spro_0879Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa)
Spro_1033Ketose-bisphosphate aldolase; KEGG: ypi:YpsIP31758_4026 putative fructose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (286 aa)
Spro_1172PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: pfo:Pfl_2479 NADH:flavin oxidoreductase/NADH oxidase. (359 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)
Spro_1287Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (327 aa)
dusCDihydrouridine synthase DuS; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily. (309 aa)
Spro_1516PFAM: ferredoxin-dependent glutamate synthase; KEGG: pap:PSPA7_1539 hypothetical protein. (540 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; histidine biosynthesis protein; KEGG: ypi:YpsIP31758_2433 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa)
deoC-2Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (226 aa)
Spro_1701Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
Spro_1838PFAM: dihydrodipicolinate synthetase; KEGG: bch:Bcen2424_4139 dihydrodipicolinate synthetase; Belongs to the DapA family. (306 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
Spro_1885NADH:flavin oxidoreductase Old Yellow Enzyme family-like protein; KEGG: eca:ECA1780 putative NADH-dependent flavin oxidoreductase. (141 aa)
Spro_1960PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: sme:SMb20498 hypothetical protein. (280 aa)
kdsATIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: ypi:YpsIP31758_2062 3-deoxy-8-phosphooctulonate synthase. (284 aa)
Spro_2172Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa)
Spro_2202PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: yen:YE2152 NADH:flavin oxidoreductase / NADH oxidase family protein. (365 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
Spro_2255KEGG: kpn:KPN_04196 putative ketose-bisphosphate aldolase, class-II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (280 aa)
Spro_2465PFAM: glycerol-3-phosphate responsive antiterminator; KEGG: ecs:ECs3623 putative anti-terminator regulatory protein. (189 aa)
Spro_2579Class II aldolase, tagatose bisphosphate family; KEGG: plu:plu0839 tagatose-bisphosphate aldolase GatY; TIGRFAM: ketose-bisphosphate aldolase; class II aldolase, tagatose bisphosphate family; PFAM: ketose-bisphosphate aldolase class-II. (284 aa)
Spro_2640Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa)
Spro_2641KEGG: yen:YE0645 putative pyruvate formate-lyase 3 activating enzyme; TIGRFAM: glycyl-radical enzyme activating protein family; PFAM: Radical SAM domain protein. (299 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (251 aa)
trpFIndole-3-glycerol-phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Indole-3-glycerol phosphate synthase; KEGG: yen:YE2212 tryptophan biosynthesis protein TrpCF. (453 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
Spro_2767KEGG: yen:YE2382 KHG/KDPG aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase. (213 aa)
mhpEPyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (333 aa)
Spro_3436PFAM: Ethanolamine ammonia lyase large subunit; KEGG: asa:ASA_0956 ethanolamine ammonia-lyase, large subunit. (461 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
Spro_3568PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: plu:plu2781 fructose-biphosphate aldolase class I (FBP aldolase). (349 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (398 aa)
pdxJPyridoxal phosphate biosynthetic protein PdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (243 aa)
Spro_3848Tagatose-6-phosphate kinase; PFAM: D-tagatose-bisphosphate aldolase class II accessory protein AgaZ; KEGG: plu:plu0833 putative tagatose 6-phosphate kinase AgaZ. (427 aa)
lldDFMN-dependent alpha-hydroxy acid dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. (380 aa)
Spro_3937PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: spt:SPA3526 putative hexulose-6-phosphate synthase. (218 aa)
Spro_3944Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
Spro_4035Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (379 aa)
Spro_4309PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ypi:YpsIP31758_0501 2,4-dienoyl-coa reductase. (673 aa)
Spro_4344PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: yen:YE3735 glutamate synthase [NADPH] large chain precursor. (1486 aa)
Spro_4374PFAM: protein of unknown function DUF1341; KEGG: ent:Ent638_0431 protein of unknown function DUF1341. (246 aa)
dusBPutative TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily. (321 aa)
dusATIM-barrel protein, yjbN family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily. (336 aa)
Spro_4500KEGG: stm:STM1884 keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase. (213 aa)
Spro_4601PFAM: ribulose-phosphate 3-epimerase; KEGG: stm:STM3483 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
Spro_4660PFAM: PfkB domain protein; KEGG: yen:YE4028 putative carbohydrate kinase. (642 aa)
Spro_4685PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; KEGG: tte:TTE2131 NADH:flavin oxidoreductase, Old Yellow enzyme family. (587 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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