STRINGSTRING
Spro_3719 Spro_3719 Spro_3767 Spro_3767 Spro_3773 Spro_3773 Spro_3807 Spro_3807 Spro_3869 Spro_3869 gcvP gcvP Spro_0053 Spro_0053 Spro_0076 Spro_0076 selA selA Spro_0112 Spro_0112 wecE wecE Spro_0233 Spro_0233 Spro_0509 Spro_0509 Spro_0607 Spro_0607 hemL hemL Spro_0798 Spro_0798 Spro_0936 Spro_0936 Spro_0941 Spro_0941 bioA bioA bioF bioF Spro_1369 Spro_1369 Spro_1440 Spro_1440 hisC hisC Spro_1626 Spro_1626 Spro_1663 Spro_1663 serC serC Spro_1729 Spro_1729 Spro_1830 Spro_1830 Spro_2017 Spro_2017 arnB arnB sufS sufS Spro_2262 Spro_2262 Spro_2418 Spro_2418 Spro_2419 Spro_2419 Spro_2493 Spro_2493 Spro_2563 Spro_2563 Spro_2789 Spro_2789 argD argD Spro_2858 Spro_2858 Spro_3028 Spro_3028 Spro_3049 Spro_3049 Spro_3088 Spro_3088 Spro_3310 Spro_3310 Spro_3347 Spro_3347 Spro_3401 Spro_3401 Spro_3618 Spro_3618 iscS iscS glyA glyA Spro_4047 Spro_4047 Spro_4067 Spro_4067 Spro_4212 Spro_4212 Spro_4220 Spro_4220 Spro_4306 Spro_4306 Spro_4307 Spro_4307 Spro_4375 Spro_4375 Spro_4445 Spro_4445 argD-2 argD-2 Spro_4786 Spro_4786 Spro_4822 Spro_4822 kbl kbl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Spro_3719PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE0931 putative GntR-family transcriptional regulatory protein. (476 aa)
Spro_3767PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: kpn:KPN_00500 lysine decarboxylase 1. (713 aa)
Spro_3773PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: yen:YE3267 lysine decarboxylase, constitutive. (714 aa)
Spro_3807PFAM: aminotransferase class V; KEGG: kpn:KPN_03161 cysteine sulfinate desulfinase. (401 aa)
Spro_3869KEGG: vpa:VP1253 NifS-related protein; TIGRFAM: cysteine desulfurase family protein; PFAM: aminotransferase class V. (409 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (959 aa)
Spro_0053PFAM: aminotransferase class I and II; KEGG: yps:YPTB3907 valine--pyruvate transaminase. (440 aa)
Spro_0076Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE4144 putative transcriptional regulator. (488 aa)
selAL-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family. (463 aa)
Spro_0112Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: syf:Synpcc7942_1725 regulatory protein GntR, HTH. (484 aa)
wecETDP-4-keto-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family. (376 aa)
Spro_0233Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: eca:ECA4336 putative aminotransferase. (395 aa)
Spro_0509PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: yen:YE0455 ornithine decarboxylase, inducible. (723 aa)
Spro_0607PFAM: aminotransferase class-III; KEGG: pna:Pnap_4039 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase. (429 aa)
Spro_0798KEGG: pfl:PFL_3514 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; Aluminium resistance family protein. (396 aa)
Spro_0936PFAM: aminotransferase class V; KEGG: eca:ECA3491 purine catabolism protein. (413 aa)
Spro_0941PFAM: aminotransferase class I and II; KEGG: eca:ECA3488 putative aminotransferase. (386 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (430 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (383 aa)
Spro_1369PFAM: aminotransferase class I and II; KEGG: bxe:Bxe_A4435 putative aminotransferase. (384 aa)
Spro_1440Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: pfo:Pfl_5531 aminotransferase, class I and II. (482 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: yen:YE2767 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa)
Spro_1626Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1469 putative cystathionine gamma-synthase. (381 aa)
Spro_1663Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1505 L-allo-threonine aldolase. (338 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
Spro_1729Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: yen:YE1561 aspartate aminotransferase. (401 aa)
Spro_1830KEGG: pla:Plav_2905 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aminotransferase class I and II. (403 aa)
Spro_2017PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: oan:Oant_4139 putative transcriptional regulator, GntR family. (505 aa)
arnBDegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (384 aa)
sufSCysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo. (406 aa)
Spro_2262PFAM: aminotransferase class I and II; KEGG: yen:YE2010 putative aminotransferase. (393 aa)
Spro_2418PFAM: Pyridoxal-dependent decarboxylase; KEGG: eca:ECA2244 L-2,4-diaminobutyrate decarboxylase. (490 aa)
Spro_2419TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: eca:ECA2243 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa)
Spro_2493TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: azo:azo0369 probable cysteine desulphurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (605 aa)
Spro_2563PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: aav:Aave_0017 transcriptional regulator, GntR family. (434 aa)
Spro_2789PFAM: aminotransferase class I and II; KEGG: aha:AHA_3110 putative aminotransferase B. (383 aa)
argDAcetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (404 aa)
Spro_2858Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE2470 putative GntR-family regulatory protein. (472 aa)
Spro_3028PFAM: aminotransferase class I and II; KEGG: stp:Strop_0458 aminotransferase, class I and II. (407 aa)
Spro_3049PFAM: Pyridoxal-dependent decarboxylase; KEGG: sen:SACE_3828 putative amino acid decarboxylase,pyridoxal-dependent protein. (471 aa)
Spro_3088Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: aha:AHA_0624 aromatic-amino-acid aminotransferase. (395 aa)
Spro_3310PFAM: aminotransferase class I and II; KEGG: yen:YE1341 probable aminotransferase. (404 aa)
Spro_3347Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE1303 hypothetical protein. (500 aa)
Spro_3401PFAM: aminotransferase class I and II; KEGG: yen:YE1231 putative aminotransferase. (411 aa)
Spro_3618PFAM: aminotransferase class I and II; KEGG: ypi:YpsIP31758_1857 aminotransferase, classes I and II. (392 aa)
iscSCysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Spro_4047PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: ypp:YPDSF_0554 ornithine decarboxylase. (720 aa)
Spro_4067PFAM: aminotransferase class I and II; KEGG: bha:BH1695 aspartate aminotransferase. (457 aa)
Spro_4212TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: eca:ECA0354 cystathionine beta-lyase. (398 aa)
Spro_4220PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: pap:PSPA7_3030 transcriptional regulator, GntR family, with aminotransferase domain. (498 aa)
Spro_4306TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class I and II; aminotransferase class-III; KEGG: kpn:KPN_03825 putative aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
Spro_4307PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: pin:Ping_0569 transcriptional regulator (GntR family) with HTH domain. (488 aa)
Spro_4375TIGRFAM: pyridoxal phosphate-dependent enzyme, putative; PFAM: L-seryl-tRNA selenium transferase; KEGG: yen:YE3780 possible L-seryl-tRNA selenocysteine synthase. (372 aa)
Spro_4445Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: yps:YPTB0377 aspartate aminotransferase. (397 aa)
argD-2Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
Spro_4786O-succinylhomoserine (thiol)-lyase; KEGG: ypi:YpsIP31758_0121 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa)
Spro_4822PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: sdy:SDY_4094 biodegradative arginine decarboxylase. (761 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (398 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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