STRINGSTRING
gyrB gyrB Spro_0109 Spro_0109 Spro_0133 Spro_0133 mutL mutL Spro_0477 Spro_0477 Spro_0570 Spro_0570 Spro_0790 Spro_0790 Spro_1028 Spro_1028 Spro_1042 Spro_1042 Spro_1066 Spro_1066 htpG htpG Spro_1245 Spro_1245 Spro_1285 Spro_1285 Spro_1499 Spro_1499 Spro_1507 Spro_1507 Spro_1959 Spro_1959 Spro_2012 Spro_2012 Spro_2591 Spro_2591 Spro_2899 Spro_2899 Spro_2985 Spro_2985 rcsD rcsD rcsC rcsC Spro_3339 Spro_3339 Spro_3404 Spro_3404 Spro_3451 Spro_3451 Spro_3489 Spro_3489 Spro_3556 Spro_3556 Spro_3590 Spro_3590 Spro_3653 Spro_3653 Spro_3731 Spro_3731 Spro_3895 Spro_3895 Spro_3911 Spro_3911 Spro_3989 Spro_3989 Spro_4054 Spro_4054 parE parE Spro_4342 Spro_4342 Spro_4588 Spro_4588 Spro_4620 Spro_4620 Spro_4735 Spro_4735 Spro_4811 Spro_4811 Spro_4882 Spro_4882
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (804 aa)
Spro_0109KEGG: fps:FP1554 hypothetical protein. (672 aa)
Spro_0133Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; MASE1 domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: ypi:YpsIP31758_4079 sensor histidine kinase UhpB. (513 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (624 aa)
Spro_0477Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE0422 two-component system sensor protein. (353 aa)
Spro_0570PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase. (720 aa)
Spro_0790Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: ypm:YP_0304 two-component regulatory protein. (906 aa)
Spro_1028Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: ypi:YpsIP31758_4031 sensory box histidine kinase/response regulator. (870 aa)
Spro_1042PAS/PAC sensor signal transduction histidine kinase; KEGG: yen:YE3181 phosphate regulon sensor protein PhoR; TIGRFAM: PAS sensor protein; Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (438 aa)
Spro_1066Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: yen:YE1614 tetrathionate reductase complex: sensory transduction histidine kinase. (585 aa)
htpGHeat shock protein Hsp90; Molecular chaperone. Has ATPase activity. (623 aa)
Spro_1245PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Osmosensitive K channel His kinase sensor; UspA domain protein; KEGG: yen:YE2963 two-component regulatory protein sensor kinase KdpD. (897 aa)
Spro_1285Hpt sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: extracellular solute-binding protein family 3; KEGG: pfo:Pfl_1864 Hpt sensor hybrid histidine kinase. (1070 aa)
Spro_1499Heavy metal sensor signal transduction histidine kinase; Member of a two-component regulatory system. (474 aa)
Spro_1507Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: pol:Bpro_0544 periplasmic sensor signal transduction histidine kinase. (488 aa)
Spro_1959Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; KEGG: yen:YE2505 two-component system, sensor kinase. (533 aa)
Spro_2012Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PhoQ Sensor domain protein; KEGG: yen:YE1717 sensor protein kinase. (485 aa)
Spro_2591Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ypi:YpsIP31758_1825 sensor protein RstB. (434 aa)
Spro_2899Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: eca:ECA2029 nitrate/nitrite sensor kinase. (594 aa)
Spro_2985CheA signal transduction histidine kinase; PFAM: CheW domain protein; ATP-binding region ATPase domain protein; Signal transducing histidine kinase homodimeric; Hpt domain protein; CheY binding; KEGG: yen:YE2577 chemotaxis protein CheA. (655 aa)
rcsDMulti-sensor signal transduction histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (900 aa)
rcsCIntegral membrane sensor hybrid histidine kinase; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (957 aa)
Spro_3339Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Two-component sensor kinase domain protein; KEGG: plu:plu3178 two-component sensor kinase. (472 aa)
Spro_3404Signal transduction histidine kinase, LytS; PFAM: GAF domain protein; ATP-binding region ATPase domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type transmembrane region; KEGG: yen:YE1228 two-component system histidine kinase. (563 aa)
Spro_3451Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE1202 putative two-component system sensor kinase. (442 aa)
Spro_3489Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: eca:ECA1900 nitrate/nitrite sensor protein. (560 aa)
Spro_3556Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE1105 two-component system, sensor kinase. (460 aa)
Spro_3590Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: reh:H16_B0524 signal transduction histidine kinase containing a receiver domain (hybrid). (594 aa)
Spro_3653Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: ypi:YpsIP31758_1150 putative sensor-like histidine kinase YfhK. (478 aa)
Spro_3731Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; SMART: PAS domain containing protein; KEGG: eca:ECA2577 two-component sensor kinase. (532 aa)
Spro_3895Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE3383 putative histidine kinase sensor. (472 aa)
Spro_3911Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: eba:ebA6233 sensor histidine kinase. (468 aa)
Spro_3989Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: eca:ECA0007 two-component system sensor kinase. (452 aa)
Spro_4054Histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sec:SC039 hypothetical protein. (547 aa)
parEDNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (631 aa)
Spro_4342Multi-sensor hybrid histidine kinase; KEGG: ypi:YpsIP31758_0469 putative aerobic respiration control sensor protein ArcB; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein. (779 aa)
Spro_4588Signal transduction histidine kinase, LytS; PFAM: ATP-binding region ATPase domain protein; histidine kinase internal region; 5TM Receptors of the LytS-YhcK type transmembrane region; SMART: GAF domain protein; KEGG: ecv:APECO1_4423 putative sensory kinase in two-component system with YehT. (561 aa)
Spro_4620Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE4005 osmolarity sensor protein. (459 aa)
Spro_4735Integral membrane sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: sec:SC039 hypothetical protein. (594 aa)
Spro_4811Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE0085 two component sensor kinase. (457 aa)
Spro_4882Signal transduction histidine kinase, nitrogen specific, NtrB; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein; KEGG: ypi:YpsIP31758_0026 nitrogen regulation protein NR(II). (349 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.