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gppA gppA Spro_0179 Spro_0179 purD purD purH purH purA purA Spro_0453 Spro_0453 Spro_0525 Spro_0525 deoB deoB deoD deoD Spro_0677 Spro_0677 apaH apaH guaC guaC dgt dgt Spro_0792 Spro_0792 Spro_0793 Spro_0793 cysD cysD cysN cysN cysC cysC surE surE Spro_0915 Spro_0915 Spro_0916 Spro_0916 Spro_0928 Spro_0928 Spro_0930 Spro_0930 Spro_0936 Spro_0936 Spro_0937 Spro_0937 Spro_0938 Spro_0938 Spro_0939 Spro_0939 gpt gpt ppnP ppnP ade ade apt apt adk adk Spro_1144 Spro_1144 Spro_1147 Spro_1147 purK purK purE purE Spro_1241 Spro_1241 Spro_1253 Spro_1253 prs prs Spro_2020 Spro_2020 Spro_2187 Spro_2187 add add Spro_2299 Spro_2299 Spro_2300 Spro_2300 Spro_2301 Spro_2301 Spro_2318 Spro_2318 Spro_2565 Spro_2565 Spro_2770 Spro_2770 purT purT amn amn Spro_3187 Spro_3187 Spro_3271 Spro_3271 Spro_3272 Spro_3272 purF purF purC purC purM purM purN purN Spro_3542 Spro_3542 guaA guaA guaB guaB ndk ndk purL purL Spro_3723 Spro_3723 Spro_3724 Spro_3724 Spro_3801 Spro_3801 Spro_3998 Spro_3998 Spro_4006 Spro_4006 Spro_4034 Spro_4034 Spro_4255 Spro_4255 cpdA cpdA Spro_4267 Spro_4267 Spro_4317 Spro_4317 Spro_4396 Spro_4396 Spro_4612 Spro_4612 Spro_4614 Spro_4614 Spro_4699 Spro_4699 gmk gmk Spro_4869 Spro_4869
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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gppAPpx/GppA phosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (498 aa)
Spro_0179PFAM: adenylate cyclase class-I; KEGG: yen:YE0189 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. (850 aa)
purDKEGG: yps:YPTB0299 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (427 aa)
purHKEGG: yps:YPTB0300 phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (529 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
Spro_0453TIGRFAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE0399 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor; Belongs to the 5'-nucleotidase family. (650 aa)
Spro_0525KEGG: yen:YE0482 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. (712 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa)
deoDTIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: yen:YE0574 purine nucleoside phosphorylase. (243 aa)
Spro_0677Protein of unknown function DUF84; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (179 aa)
apaHBis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (283 aa)
guaCGuanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (347 aa)
dgtPutative deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (505 aa)
Spro_0792(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (743 aa)
Spro_0793TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ypi:YpsIP31758_3318 MazG family protein. (264 aa)
cysDTIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: yen:YE0762 sulfate adenylyltransferase subunit 2. (302 aa)
cysNSulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (481 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (209 aa)
surEStationary-phase survival protein SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (253 aa)
Spro_0915PFAM: Asp/Glu racemase; KEGG: kpn:KPN_01788 putative hydantoin racemase. (247 aa)
Spro_0916PFAM: polysaccharide deacetylase; KEGG: ypi:YpsIP31758_1058 polysaccharide deacetylase family protein. (312 aa)
Spro_0928TIGRFAM: Amidohydrolase AtzE type; PFAM: Amidase; KEGG: ypi:YpsIP31758_3194 amidohydrolase, AtzE family. (466 aa)
Spro_0930Gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; KEGG: eca:ECA3497 putative gamma-glutamyltranspeptidase. (528 aa)
Spro_0936PFAM: aminotransferase class V; KEGG: eca:ECA3491 purine catabolism protein. (413 aa)
Spro_0937Amidase, hydantoinase/carbamoylase family; KEGG: yps:YPTB0871 N-carbamoyl-L-amino acid amidohydrolase; TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20; peptidase dimerisation domain protein. (418 aa)
Spro_0938KEGG: nca:Noca_1144 putative urate oxidase, N-terminal. (166 aa)
Spro_0939PFAM: Transthyretin; KEGG: sen:SACE_6735 transthyretin; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (111 aa)
gptXanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (152 aa)
ppnPProtein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (96 aa)
adeAdenine deaminase; PFAM: amidohydrolase; KEGG: kpn:KPN_02554 putative amidohydrolase. (595 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (198 aa)
adkNucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (214 aa)
Spro_1144Inosine kinase; PFAM: PfkB domain protein; KEGG: yen:YE3069 inosine-guanosine kinase. (434 aa)
Spro_1147PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family. (551 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (174 aa)
Spro_1241TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: yen:YE2967 phosphoglucomutase. (547 aa)
Spro_1253PFAM: cyclic-AMP phosphodiesterase class-II; KEGG: yen:YE2956 putative 3',5'-cyclic-nucleotide phosphodiesterase. (326 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
Spro_2020KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
Spro_2187KEGG: yen:YE2164 pyruvate kinase I; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (470 aa)
addKEGG: yen:YE2009 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (332 aa)
Spro_2299Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (443 aa)
Spro_2300TIGRFAM: Xanthine dehydrogenase small subunit; PFAM: ferredoxin; molybdopterin dehydrogenase FAD-binding; [2Fe-2S]-binding domain protein; CO dehydrogenase flavoprotein domain protein; KEGG: pst:PSPTO_3660 xanthine dehydrogenase, N-terminal subunit. (476 aa)
Spro_2301KEGG: pau:PA14_44740 xanthine dehydrogenase; TIGRFAM: Xanthine dehydrogenase molybdopterin binding subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding. (797 aa)
Spro_2318PFAM: monooxygenase FAD-binding; KEGG: kpn:KPN_01663 putative flavoprotein monooxygenase. (385 aa)
Spro_2565PFAM: glutamine amidotransferase class-I; KEGG: cvi:CV_3746 glutamine amidotransferase. (238 aa)
Spro_2770KEGG: eca:ECA2481 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (480 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (392 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (486 aa)
Spro_3187Carbamate kinase; KEGG: hip:CGSHiEE_09190 carbamate kinase; TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the carbamate kinase family. (308 aa)
Spro_3271Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (762 aa)
Spro_3272PFAM: ribonucleotide reductase; KEGG: yen:YE1392 ribonucleoside-diphosphate reductase 1 beta chain. (376 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
purCKEGG: ypi:YpsIP31758_1249 phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (237 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; KEGG: yen:YE1127 putative phosphoribosylaminoimidazole synthetase; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein. (359 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
Spro_3542PFAM: Ppx/GppA phosphatase; KEGG: ypi:YpsIP31758_1226 exopolyphosphatase; Belongs to the GppA/Ppx family. (516 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1296 aa)
Spro_3723Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (714 aa)
Spro_3724Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
Spro_3801PFAM: conserved hypothetical protein; KEGG: eca:ECA1019 lysine decarboxylase family protein. (454 aa)
Spro_3998KEGG: yps:YPTB0723 hypoxanthine-guanine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa)
Spro_4006Phosphopentomutase; PFAM: metalloenzyme domain protein; Phosphopentomutase domain protein; KEGG: yen:YE3104 metalloenzyme superfamily protein. (411 aa)
Spro_4034Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
Spro_4255Xanthosine phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (285 aa)
cpdACalcineurin phosphoesterase domain protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
Spro_4267ADP-ribose diphosphatase; PFAM: NUDIX hydrolase; KEGG: ypi:YpsIP31758_0574 hydrolase, NUDIX family. (210 aa)
Spro_4317PFAM: glutamine amidotransferase class-I; KEGG: bpe:BP1437 glutamine amidotransferase. (243 aa)
Spro_4396Purine nucleosidase; PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: aau:AAur_3646 putative inosine-uridine preferring nucleoside hydrolase (IunH); Belongs to the IUNH family. (314 aa)
Spro_4612PFAM: NUDIX hydrolase; KEGG: ypi:YpsIP31758_3973 ADP compounds hydrolase NudE. (184 aa)
Spro_4614TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE3983 hypothetical protein. (225 aa)
Spro_4699PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: eca:ECA0053 putative phosphodiesterase; Belongs to the 5'-nucleotidase family. (616 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)
Spro_4869(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (703 aa)
Your Current Organism:
Serratia proteamaculans
NCBI taxonomy Id: 399741
Other names: S. proteamaculans 568, Serratia proteamaculans 568, Serratia proteamaculans str. 568, Serratia proteamaculans strain 568
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