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| | Spro_0037 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE4167 pyridoxal-phosphate dependent enzyme. (322 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa) |
| | argI | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (339 aa) |
| | Spro_0666 | KEGG: yen:YE0578 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3. (325 aa) |
| | gpmB | PFAM: Phosphoglycerate mutase; KEGG: plu:plu0559 phosphoglyceromutase 2; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | Spro_0683 | Aspartate kinase; KEGG: yps:YPTB0602 bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal); TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding. (819 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (309 aa) |
| | Spro_0685 | KEGG: yps:YPTB0604 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit. (429 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | Spro_0708 | KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (570 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (273 aa) |
| | Spro_0733 | PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit. (97 aa) |
| | Spro_0734 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eca:ECA3848 acetolactate synthase isozyme I large subunit. (564 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | Spro_0748 | KEGG: yen:YE0658 acetolactate synthase isozyme III large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein. (572 aa) |
| | Spro_0749 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: yen:YE0659 acetolactate synthase isozyme III small subunit. (163 aa) |
| | mtnN | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP [...] (233 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa) |
| | Spro_0879 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | Spro_0880 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: yen:YE0851 T-protein. (373 aa) |
| | Spro_0881 | TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: yen:YE0852 P-protein. (385 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (417 aa) |
| | aroL | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (174 aa) |
| | Spro_1033 | Ketose-bisphosphate aldolase; KEGG: ypi:YpsIP31758_4026 putative fructose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (286 aa) |
| | Spro_1044 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (368 aa) |
| | Spro_1105 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE3124 putative pyridoxal-phosphate dependent protein. (347 aa) |
| | Spro_1222 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: kpn:KPN_00695 asparagine synthetase B. (554 aa) |
| | Spro_1262 | KEGG: yen:YE2949 citrate synthase GltA; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (430 aa) |
| | Spro_1287 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (351 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | hisI | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: yen:YE2772 histidine biosynthesis bifunctional protein [includes: phosphoribosyl-amp cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. (204 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; histidine biosynthesis protein; KEGG: ypi:YpsIP31758_2433 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisB | KEGG: yen:YE2768 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family. (355 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: yen:YE2767 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (362 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. (299 aa) |
| | Spro_1626 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1469 putative cystathionine gamma-synthase. (381 aa) |
| | Spro_1627 | PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE1470 cystathionine beta-lyase. (455 aa) |
| | Spro_1629 | KEGG: yen:YE1472 L-serine dehydratase 2; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa) |
| | Spro_1636 | PFAM: purine or other phosphorylase family 1; KEGG: btl:BALH_2989 putative 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase. (279 aa) |
| | Spro_1638 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pfl:PFL_3440 serine/threonine dehydratase family protein. (322 aa) |
| | Spro_1663 | Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1505 L-allo-threonine aldolase. (338 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | Spro_1729 | Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: yen:YE1561 aspartate aminotransferase. (401 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | Spro_2025 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: ypi:YpsIP31758_1615 isocitrate dehydrogenase, NADP-dependent. (417 aa) |
| | Spro_2074 | Chorismate mutase, putative; Catalyzes the Claisen rearrangement of chorismate to prephenate. (176 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | Spro_2172 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (348 aa) |
| | Spro_2187 | KEGG: yen:YE2164 pyruvate kinase I; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (470 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | Spro_2255 | KEGG: kpn:KPN_04196 putative ketose-bisphosphate aldolase, class-II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (280 aa) |
| | Spro_2258 | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa) |
| | Spro_2262 | PFAM: aminotransferase class I and II; KEGG: yen:YE2010 putative aminotransferase. (393 aa) |
| | Spro_2419 | TIGRFAM: 2,4-diaminobutyrate 4-transaminase; PFAM: aminotransferase class-III; KEGG: eca:ECA2243 diaminobutyrate--2-oxoglutarate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (464 aa) |
| | Spro_2495 | KEGG: mpt:Mpe_A0026 serine O-acetyltransferase. (256 aa) |
| | Spro_2654 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa) |
| | Spro_2667 | KEGG: eca:ECA2296 anthranilate synthase component I; TIGRFAM: anthranilate synthase component I; PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like. (520 aa) |
| | Spro_2668 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: yen:YE2210 anthranilate synthase component II. (193 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (332 aa) |
| | trpF | Indole-3-glycerol-phosphate synthase/phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Indole-3-glycerol phosphate synthase; KEGG: yen:YE2212 tryptophan biosynthesis protein TrpCF. (453 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | Spro_2728 | KEGG: ypi:YpsIP31758_1987 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | Spro_2770 | KEGG: eca:ECA2481 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (480 aa) |
| | Spro_2789 | PFAM: aminotransferase class I and II; KEGG: aha:AHA_3110 putative aminotransferase B. (383 aa) |
| | Spro_2810 | KEGG: ypi:YpsIP31758_2355 L-serine ammonia-lyase; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (461 aa) |
| | Spro_3024 | PFAM: ornithine cyclodeaminase/mu-crystallin; KEGG: stp:Strop_0460 ornithine cyclodeaminase/mu-crystallin. (318 aa) |
| | Spro_3088 | Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: aha:AHA_0624 aromatic-amino-acid aminotransferase. (395 aa) |
| | Spro_3119 | KEGG: kpn:KPN_01710 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | Spro_3176 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: ent:Ent638_2113 methionine synthase, vitamin-B12 independent. (343 aa) |
| | argI-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (312 aa) |
| | Spro_3294 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: stp:Strop_3951 thiamine pyrophosphate enzyme domain protein TPP-binding; Belongs to the TPP enzyme family. (609 aa) |
| | Spro_3310 | PFAM: aminotransferase class I and II; KEGG: yen:YE1341 probable aminotransferase. (404 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa) |
| | Spro_3432 | TIGRFAM: acetolactate synthase, catabolic; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aha:AHA_1126 acetolactate synthase, catabolic; Belongs to the TPP enzyme family. (561 aa) |
| | Spro_3447 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yps:YPTB2714 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa) |
| | Spro_3453 | TIGRFAM: cysteine synthase; cysteine synthase B; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: ypi:YpsIP31758_1303 cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (316 aa) |
| | Spro_3480 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | Spro_3568 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: plu:plu2781 fructose-biphosphate aldolase class I (FBP aldolase). (349 aa) |
| | Spro_3618 | PFAM: aminotransferase class I and II; KEGG: ypi:YpsIP31758_1857 aminotransferase, classes I and II. (392 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | dapD | TIGRFAM: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; KEGG: ssn:SSON_0178 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (274 aa) |
| | argA | TIGRFAM: amino-acid N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase; aspartate/glutamate/uridylate kinase; KEGG: yen:YE3308 amino-acid acetyltransferase; Belongs to the acetyltransferase family. ArgA subfamily. (441 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | Spro_3923 | PFAM: amino acid-binding ACT domain protein; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: yen:YE3400 D-3-phosphoglycerate dehydrogenase. (412 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (239 aa) |
| | Spro_3944 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: yen:YE3414 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | Spro_3954 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | Spro_3956 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: kpn:KPN_03360 putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (547 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa) |
| | Spro_4008 | PFAM: aconitate hydratase domain protein; aconitate hydratase 2; KEGG: yen:YE0705 aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (865 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | Spro_4067 | PFAM: aminotransferase class I and II; KEGG: bha:BH1695 aspartate aminotransferase. (457 aa) |
| | Spro_4212 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: eca:ECA0354 cystathionine beta-lyase. (398 aa) |
| | Spro_4344 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: yen:YE3735 glutamate synthase [NADPH] large chain precursor. (1486 aa) |
| | Spro_4345 | TIGRFAM: glutamate synthase, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: ypi:YpsIP31758_0465 glutamate synthase, small subunit. (472 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | Spro_4445 | Aromatic-amino-acid transaminase; PFAM: aminotransferase class I and II; KEGG: yps:YPTB0377 aspartate aminotransferase. (397 aa) |
| | Spro_4447 | Arogenate dehydratase; PFAM: extracellular solute-binding protein family 3; KEGG: pfo:Pfl_3814 extracellular solute-binding protein, family 3; Belongs to the bacterial solute-binding protein 3 family. (255 aa) |
| | Spro_4479 | Aspartate kinase; KEGG: ypi:YpsIP31758_0301 asparate kinase, monofunctional class; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (455 aa) |
| | Spro_4490 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1209 aa) |
| | metAS | Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | argD-2 | Acetylornithine and succinylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa) |
| | Spro_4601 | PFAM: ribulose-phosphate 3-epimerase; KEGG: stm:STM3483 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (366 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (367 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa) |
| | ilvA | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (514 aa) |
| | ilvD | KEGG: eca:ECA4226 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (616 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (308 aa) |
| | Spro_4759 | KEGG: yen:YE0149 acetolactate synthase isozyme II small subunit. (85 aa) |
| | Spro_4760 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yen:YE0148 acetolactate synthase isozyme II large subunit. (548 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: yen:YE0121 putative argininosuccinate lyase. (457 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: plu:plu4742 argininosuccinate synthase (citrulline-aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | argE | KEGG: ypi:YpsIP31758_0126 acetylornithine deacetylase (ArgE); TIGRFAM: acetylornithine deacetylase (ArgE); PFAM: peptidase M20; peptidase dimerisation domain protein. (381 aa) |
| | Spro_4785 | Aspartate kinase; KEGG: yen:YE0112 bifunctional aspartokinase/homoserine dehydrogenase II; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; In the C-terminal section; belongs to the homoserine dehydrogenase family. (811 aa) |
| | Spro_4786 | O-succinylhomoserine (thiol)-lyase; KEGG: ypi:YpsIP31758_0121 cystathionine gamma-synthase; TIGRFAM: O-succinylhomoserine (thiol)-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein. (386 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa) |
| | Spro_4814 | KEGG: yen:YE0082 serine acetyltransferase; TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; serine acetyltransferase domain protein. (273 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (514 aa) |
| | Spro_4881 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: yen:YE0027 glutamine synthetase. (469 aa) |
| | asnA | PFAM: aspartate--ammonia ligase; KEGG: yen:YE0003 aspartate-ammonia ligase. (330 aa) |
