STRINGSTRING
pgi pgi ABP59130.1 ABP59130.1 ABP59145.1 ABP59145.1 ABP59548.1 ABP59548.1 ABP59668.1 ABP59668.1 ABP59873.1 ABP59873.1 nagB nagB ABP59875.1 ABP59875.1 ABP59884.1 ABP59884.1 galK galK ABP59930.1 ABP59930.1 ABP59931.1 ABP59931.1 ABP60295.1 ABP60295.1 nagZ nagZ nagK nagK ABP60506.1 ABP60506.1 ABP60509.1 ABP60509.1 ABP60633.1 ABP60633.1 ABP60695.1 ABP60695.1 arnD arnD arnA arnA arnC arnC arnB arnB ABP60976.1 ABP60976.1 ABP61055.1 ABP61055.1 ABP61056.1 ABP61056.1 ABP61057.1 ABP61057.1 ABP61223.1 ABP61223.1 ABP61307.1 ABP61307.1 ABP61308.1 ABP61308.1 ABP61310.1 ABP61310.1 ABP61311.1 ABP61311.1 ABP61322.1 ABP61322.1 ABP61328.1 ABP61328.1 ABP61329.1 ABP61329.1 fcl fcl gmd gmd glk glk ABP61609.1 ABP61609.1 ABP61660.1 ABP61660.1 ABP61679.1 ABP61679.1 murQ murQ nanE nanE ABP61895.1 ABP61895.1 glmM glmM murA murA ABP62316.1 ABP62316.1 nanA nanA glgC glgC murB murB wecC wecC wecB wecB glmU glmU glmS glmS
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pgiPFAM: phosphoglucose isomerase (PGI); KEGG: sdy:SDY_4226 glucosephosphate isomerase; Belongs to the GPI family. (549 aa)
ABP59130.1beta-N-acetylhexosaminidase; PFAM: glycoside hydrolase, family 20; KEGG: ppr:PBPRA1268 beta-N-acetylhexosaminidase. (794 aa)
ABP59145.1Alpha-N-arabinofuranosidase; PFAM: glycoside hydrolase, family 43; KEGG: ecj:JW0264 predicted xylosidase/arabinosidase; Belongs to the glycosyl hydrolase 43 family. (539 aa)
ABP59548.1N-acetylglucosamine kinase; PFAM: ROK family protein; KEGG: sdy:SDY_0345 possible NAGC-like transcriptional regulator. (301 aa)
ABP59668.1Glucose PTS system EIICBA or EIICB component; TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: gka:GK0991 PTS system, glucose-specific enzyme II, A component; TC 4.A.1.1.9; TC 4.A.1.1.9. (499 aa)
ABP59873.1KEGG: stm:STM0683 N-acetylglucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: amidohydrolase. (382 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
ABP59875.1N-acetylglucosamine PTS system EIICBA or EIICB component; TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, N-acetylglucosamine-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: sugar-specific permease, EIIA 1 domain; phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: yps:YPTB1120 PTS system, N-acetylglucosamine-specific IIABC component; TC 4.A.1.1.2; TC 4.A.1.1.2; TC 4.A.1.1.2. (673 aa)
ABP59884.1TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: stt:t2177 phosphoglucomutase. (546 aa)
galKGalactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (382 aa)
ABP59930.1KEGG: ecc:c0834 galactose-1-phosphate uridylyltransferase; TIGRFAM: galactose-1-phosphate uridylyltransferase; PFAM: galactose-1-phosphate uridyl transferase domain protein. (348 aa)
ABP59931.1TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: ssn:SSO_0711 UDP-galactose-4-epimerase. (338 aa)
ABP60295.1KEGG: sdy:SDY_2049 PTS system, glucose-specific IIBC component; TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; TC 4.A.1.1.1; TC 4.A.1.1.1. (477 aa)
nagZbeta-N-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (337 aa)
nagKROK family protein; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (303 aa)
ABP60506.1KEGG: ecp:ECP_1565 PTS system, maltose and glucose-specific IIABC component; TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, maltose and glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; TC 4.A.1; TC 4.A.1. (530 aa)
ABP60509.1KEGG: ecs:ECs2319 mannose-6-phosphate isomerase; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase, type I. (391 aa)
ABP60633.1PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: sme:SMa0715 putative UDP-glucose 4-epimerase. (375 aa)
ABP60695.1PFAM: PfkB domain protein; KEGG: ecp:ECP_2750 fructokinase; Belongs to the carbohydrate kinase PfkB family. (298 aa)
arnDPolysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (298 aa)
arnANAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (660 aa)
arnCGlycosyl transferase, family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa)
arnBDegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (379 aa)
ABP60976.1UDP-glucose pyrophosphorylase; KEGG: stm:STM1752 glucose-1-phosphate uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase. (302 aa)
ABP61055.1TIGRFAM: PTS system, mannose/fructose/sorbose family, IIB subunit; PTS system, mannose/fructose/sorbose family, IIA subunit; PFAM: PTS system fructose subfamily IIA component; PTS system sorbose subfamily IIB component; KEGG: sbo:SBO_1229 PTS enzyme IIAB, mannose-specific; TC 4.A.6.1.1; TC 4.A.6.1.1. (320 aa)
ABP61056.1TIGRFAM: PTS system, mannose/fructose/sorbose family, IIC subunit; PFAM: phosphotransferase system PTS, sorbose-specific IIC subunit; KEGG: stm:STM1831 Sugar Specific PTS family, mannose-specific enzyme IIC; TC 4.A.6.1.1. (266 aa)
ABP61057.1TIGRFAM: PTS system, mannose/fructose/sorbose family, IID subunit; PFAM: PTS system mannose/fructose/sorbose family IID component; KEGG: stm:STM1832 Sugar Specific PTS family, mannose-specific enzyme IID; TC 4.A.6.1.1. (283 aa)
ABP61223.1KEGG: ppr:PBPRB0267 putative GckR family protein. (287 aa)
ABP61307.1PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain; KEGG: sgl:SG1369 putative nucleotide sugar epimerase. (334 aa)
ABP61308.1PFAM: UDP-glucose/GDP-mannose dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: sbo:SBO_0857 UDP-glucose 6-dehydrogenase. (388 aa)
ABP61310.1Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: ssn:SSO_2101 phosphomannomutase. (457 aa)
ABP61311.1Mannose-6-phosphate isomerase, type 2; KEGG: ecj:JW2034 mannose-1-phosphate guanyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase, type II; Nucleotidyl transferase; Cupin 2, conserved barrel domain protein. (475 aa)
ABP61322.1UDP-glucose pyrophosphorylase regulatory subunit; KEGG: stm:STM2098 putative glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase), non-catalytic subunit; TIGRFAM: regulatory protein GalF; PFAM: Nucleotidyl transferase. (298 aa)
ABP61328.1Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: ecv:APECO1_1138 phosphomannomutase. (456 aa)
ABP61329.1KEGG: ssn:SSO_2102 mannose-1-phosphate guanyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase, type II; Nucleotidyl transferase; Cupin 2, conserved barrel domain protein. (478 aa)
fclNAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (373 aa)
glkGlucokinase; KEGG: ecv:APECO1_4149 glucokinase; TIGRFAM: glucokinase; PFAM: Glucokinase; Belongs to the bacterial glucokinase family. (321 aa)
ABP61609.1KEGG: ssn:SSO_2506 PTS system, glucose-specific IIA component; TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease, EIIA 1 domain; TC 4.A.1.1.1. (169 aa)
ABP61660.1Alpha-N-arabinofuranosidase; PFAM: glycoside hydrolase, family 43; Glycosyl hydrolase family 32, N terminal domain protein; KEGG: lla:L0234 beta-1,4-xylosidase; Belongs to the glycosyl hydrolase 43 family. (559 aa)
ABP61679.1PTS system IIC component, Glc family / PTS system IIB component, Glc family; KEGG: eca:ECA3225 PTS system, alpha-glucoside-specific IIbc component; TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; TC 4.A.1; TC 4.A.1. (514 aa)
murQGlucokinase regulatory-like protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (297 aa)
nanEN-acylglucosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (235 aa)
ABP61895.1PTS system IIC component, Glc family / PTS system IIB component, Glc family; TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC; KEGG: bcl:ABC0713 PTS system, glucose-specific enzyme II, ABC component; TC 4.A.1; TC 4.A.1. (518 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (445 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
ABP62316.1N-acetylmannosamine kinase; PFAM: ROK family protein; KEGG: stt:t3253 putative N-acetylmannosamine kinase. (289 aa)
nanAN-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (297 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. (431 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (342 aa)
wecCUDP-glucose/GDP-mannose dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily. (420 aa)
wecBUDP-N-Acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. (376 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
glmSGlutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
Your Current Organism:
Enterobacter sp. 638
NCBI taxonomy Id: 399742
Other names: E. sp. 638
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