STRINGSTRING
SFR31200.1 SFR31200.1 SFR31219.1 SFR31219.1 SFR31239.1 SFR31239.1 SFR31402.1 SFR31402.1 purA purA pyrE pyrE ftsH ftsH thyA thyA SFR32742.1 SFR32742.1 gcvH gcvH SFR33304.1 SFR33304.1 gmk gmk SFR35332.1 SFR35332.1 SFR35338.1 SFR35338.1 SFR35389.1 SFR35389.1 dut dut purD purD tdk tdk SFR37261.1 SFR37261.1 purN purN SFR37565.1 SFR37565.1 SFR37762.1 SFR37762.1 SFR38603.1 SFR38603.1 SFR38990.1 SFR38990.1 SFR39136.1 SFR39136.1 purH purH der der SFR44998.1 SFR44998.1 SFR45006.1 SFR45006.1 glyA glyA SFR46155.1 SFR46155.1 SFR47392.1 SFR47392.1 SFR48049.1 SFR48049.1 purC purC gcvT gcvT pyrB pyrB SFR49172.1 SFR49172.1 cmk cmk SFR49790.1 SFR49790.1 guaB guaB pyrD pyrD purU purU pyrF pyrF SFR51341.1 SFR51341.1 apt apt SFR52211.1 SFR52211.1 folD folD fhs fhs carA carA adk adk purK purK purE purE gcvP gcvP SFR54496.1 SFR54496.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFR31200.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (447 aa)
SFR31219.1Carbamoyl-phosphate synthase large subunit. (950 aa)
SFR31239.1Phosphoribosylformylglycinamidine synthase. (1217 aa)
SFR31402.1Uridine kinase. (202 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
ftsHCell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (667 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
SFR32742.1Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (191 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
SFR33304.1Inosine-uridine nucleoside N-ribohydrolase. (302 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (192 aa)
SFR35332.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (829 aa)
SFR35338.1Ribonucleoside-diphosphate reductase beta chain. (328 aa)
SFR35389.1dCMP deaminase. (150 aa)
dutdUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
tdkThymidine kinase. (215 aa)
SFR37261.1Amidophosphoribosyltransferase. (630 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)
SFR37565.1Membrane protein required for colicin V production. (172 aa)
SFR37762.15-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (187 aa)
SFR38603.1Dihydroorotase. (445 aa)
SFR38990.1Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. (298 aa)
SFR39136.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (510 aa)
derGTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (433 aa)
SFR44998.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (304 aa)
SFR45006.15'-nucleotidase, C-terminal domain. (258 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
SFR46155.1Dihydroorotase. (417 aa)
SFR47392.1Uridine phosphorylase. (295 aa)
SFR48049.1Adenosine kinase. (327 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (321 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (361 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (309 aa)
SFR49172.1Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase. (179 aa)
cmkCytidylate kinase. (234 aa)
SFR49790.1Pyrimidine operon attenuation protein / uracil phosphoribosyltransferase. (165 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (345 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (290 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (271 aa)
SFR51341.1Phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
SFR52211.1Adenosine deaminase. (327 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
fhsFormate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (375 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (371 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa)
SFR54496.1Cytidine deaminase. (160 aa)
Your Current Organism:
Robiginitalea myxolifaciens
NCBI taxonomy Id: 400055
Other names: DSM 21019, Flavobacteriaceae bacterium YM6-073, KCTC 22216, MBIC 06409, R. myxolifaciens, Robiginitalea myxolifaciens Manh et al. 2008, strain YM6-073
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