STRINGSTRING
truA-2 truA-2 adk adk SFR31191.1 SFR31191.1 SFR31200.1 SFR31200.1 SFR31232.1 SFR31232.1 SFR31239.1 SFR31239.1 ndk ndk SFR54679.1 SFR54679.1 SFR31484.1 SFR31484.1 purA purA SFR31593.1 SFR31593.1 SFR32658.1 SFR32658.1 SFR32690.1 SFR32690.1 SFR32786.1 SFR32786.1 SFR32869.1 SFR32869.1 SFR32943.1 SFR32943.1 SFR33304.1 SFR33304.1 SFR34135.1 SFR34135.1 SFR34291.1 SFR34291.1 SFR34361.1 SFR34361.1 SFR34609.1 SFR34609.1 SFR35184.1 SFR35184.1 gmk gmk SFR35332.1 SFR35332.1 SFR35338.1 SFR35338.1 SFR35582.1 SFR35582.1 SFR35614.1 SFR35614.1 SFR35840.1 SFR35840.1 SFR35845.1 SFR35845.1 purD purD SFR36861.1 SFR36861.1 SFR37261.1 SFR37261.1 purN purN SFR37320.1 SFR37320.1 SFR37335.1 SFR37335.1 SFR37855.1 SFR37855.1 SFR37870.1 SFR37870.1 SFR38162.1 SFR38162.1 SFR38188.1 SFR38188.1 SFR38352.1 SFR38352.1 purK purK SFR38469.1 SFR38469.1 SFR38654.1 SFR38654.1 SFR38793.1 SFR38793.1 SFR39136.1 SFR39136.1 SFR39251.1 SFR39251.1 purH purH SFR39600.1 SFR39600.1 SFR44998.1 SFR44998.1 SFR45006.1 SFR45006.1 SFR45921.1 SFR45921.1 ychF ychF truA truA SFR47633.1 SFR47633.1 SFR47704.1 SFR47704.1 tilS tilS SFR48049.1 SFR48049.1 SFR48217.1 SFR48217.1 SFR48222.1 SFR48222.1 purE purE purC purC SFR48290.1 SFR48290.1 SFR48462.1 SFR48462.1 SFR48497.1 SFR48497.1 SFR48511.1 SFR48511.1 cysC cysC SFR48522.1 SFR48522.1 SFR48617.1 SFR48617.1 SFR48792.1 SFR48792.1 SFR49188.1 SFR49188.1 guaA guaA SFR50505.1 SFR50505.1 guaB guaB SFR51341.1 SFR51341.1 SFR55376.1 SFR55376.1 apt apt SFR52211.1 SFR52211.1 SFR52586.1 SFR52586.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
truA-2tRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (249 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (371 aa)
SFR31191.1XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
SFR31200.1Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (447 aa)
SFR31232.1Phosphoglucomutase/phosphomannomutase, C-terminal domain. (572 aa)
SFR31239.1Phosphoribosylformylglycinamidine synthase. (1217 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
SFR54679.1Adenylate cyclase. (364 aa)
SFR31484.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (735 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
SFR31593.1S1/P1 Nuclease. (257 aa)
SFR32658.1Deoxyadenosine/deoxycytidine kinase. (204 aa)
SFR32690.1Electron transfer flavoprotein beta subunit. (248 aa)
SFR32786.1CBS domain-containing protein. (219 aa)
SFR32869.12-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase. (389 aa)
SFR32943.1Nucleotidyltransferase. (93 aa)
SFR33304.1Inosine-uridine nucleoside N-ribohydrolase. (302 aa)
SFR34135.1Hypothetical protein. (671 aa)
SFR34291.1Ribose-phosphate pyrophosphokinase. (313 aa)
SFR34361.1Magnesium transporter; Acts as a magnesium transporter. (450 aa)
SFR34609.1CBS domain-containing protein. (156 aa)
SFR35184.1dGTPase. (450 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (192 aa)
SFR35332.1Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (829 aa)
SFR35338.1Ribonucleoside-diphosphate reductase beta chain. (328 aa)
SFR35582.1Endonuclease/Exonuclease/phosphatase family protein. (312 aa)
SFR35614.1Hemolysin, contains CBS domains. (366 aa)
SFR35840.1Diadenosine tetraphosphate (Ap4A) hydrolase. (326 aa)
SFR35845.1TolB amino-terminal domain-containing protein. (675 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (423 aa)
SFR36861.1Uncharacterized conserved protein YegP, UPF0339 family. (184 aa)
SFR37261.1Amidophosphoribosyltransferase. (630 aa)
purNFormyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)
SFR37320.1Pyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
SFR37335.1CYTH domain-containing protein. (158 aa)
SFR37855.1Endonuclease/Exonuclease/phosphatase family protein. (356 aa)
SFR37870.1Lamin Tail Domain. (459 aa)
SFR38162.1DNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. (96 aa)
SFR38188.1Gliding motility-associated protein GldE. (448 aa)
SFR38352.1Histidine triad (HIT) family protein. (131 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa)
SFR38469.1Uncharacterized membrane-anchored protein YitT, contains DUF161 and DUF2179 domains. (288 aa)
SFR38654.1Por secretion system C-terminal sorting domain-containing protein. (102 aa)
SFR38793.1Predicted metal-dependent phosphohydrolase, HD superfamily. (401 aa)
SFR39136.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
SFR39251.1Hemolysin, contains CBS domains. (409 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (510 aa)
SFR39600.1Calcineurin-like phosphoesterase superfamily domain-containing protein. (342 aa)
SFR44998.15'-nucleotidase; Belongs to the 5'-nucleotidase family. (304 aa)
SFR45006.15'-nucleotidase, C-terminal domain. (258 aa)
SFR45921.1Hypothetical protein. (104 aa)
ychFHypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (364 aa)
truAtRNA pseudouridine38-40 synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (260 aa)
SFR47633.1Hypothetical protein; Belongs to the LOG family. (228 aa)
SFR47704.1Type I restriction enzyme R protein N terminus (HSDR_N). (157 aa)
tilStRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (435 aa)
SFR48049.1Adenosine kinase. (327 aa)
SFR48217.1DNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. (90 aa)
SFR48222.1Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (185 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (321 aa)
SFR48290.1Hypothetical protein. (276 aa)
SFR48462.1Phosphoribosylglycinamide formyltransferase-1. (199 aa)
SFR48497.1Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (418 aa)
SFR48511.1Sulfate adenylyltransferase subunit 2. (301 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (199 aa)
SFR48522.1Uncharacterized membrane protein. (141 aa)
SFR48617.1Predicted PurR-regulated permease PerM. (366 aa)
SFR48792.1Hypothetical protein; Belongs to the LOG family. (245 aa)
SFR49188.1LysM domain-containing protein. (126 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (509 aa)
SFR50505.1XTP/dITP diphosphohydrolase. (272 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
SFR51341.1Phosphoribosylformylglycinamidine cyclo-ligase. (392 aa)
SFR55376.1Adenylate cyclase. (363 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa)
SFR52211.1Adenosine deaminase. (327 aa)
SFR52586.15'(3')-deoxyribonucleotidase. (172 aa)
Your Current Organism:
Robiginitalea myxolifaciens
NCBI taxonomy Id: 400055
Other names: DSM 21019, Flavobacteriaceae bacterium YM6-073, KCTC 22216, MBIC 06409, R. myxolifaciens, Robiginitalea myxolifaciens Manh et al. 2008, strain YM6-073
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