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lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (333 aa) | ||||
lipB | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (229 aa) | ||||
Rpic_0346 | Coenzyme A transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family. (554 aa) | ||||
sucC | succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) | ||||
sucD | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa) | ||||
Rpic_0534 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (287 aa) | ||||
Rpic_0535 | TIGRFAM: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rso:RSp0069 probable bifunctional: glutathione-dependent formaldehyde dehydrogenase and alcohol dehydrogenase class III oxidoreductase protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa) | ||||
Rpic_0656 | TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: mms:mma_2905 succinate-semialdehyde dehydrogenase (NADP+). (503 aa) | ||||
glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) | ||||
Rpic_0817 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa) | ||||
thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) | ||||
accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa) | ||||
Rpic_1097 | 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: rso:RSc1269 alpha-ketoglutarate decarboxylase; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region. (954 aa) | ||||
Rpic_1098 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (416 aa) | ||||
Rpic_1099 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1271 dihydrolipoamide dehydrogenase. (478 aa) | ||||
Rpic_1100 | PFAM: AFG1-family ATPase; KEGG: rso:RSc1272 hypothetical protein. (365 aa) | ||||
Rpic_1335 | Succinate CoA transferase; KEGG: reu:Reut_A1290 acetyl-CoA hydrolase; TIGRFAM: succinate CoA transferase; PFAM: acetyl-CoA hydrolase/transferase. (515 aa) | ||||
Rpic_1338 | PFAM: Aldehyde Dehydrogenase_; KEGG: rso:RSc1456 putative betaine aldehyde dehydrogenase (BADH) oxidoreductase protein; Belongs to the aldehyde dehydrogenase family. (478 aa) | ||||
Rpic_1397 | KEGG: rso:RS05555 hypothetical protein. (340 aa) | ||||
Rpic_1435 | PFAM: iron-containing alcohol dehydrogenase; KEGG: rso:RSc1771 probable NAD-dependent 4-hydroxybutyrate dehydrogenase oxidoreductase protein. (382 aa) | ||||
Rpic_1789 | PFAM: alkylmercury lyase; KEGG: mms:mma_1753 organomercurial lyase. (218 aa) | ||||
Rpic_1910 | KEGG: rso:RSc1637 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) | ||||
Rpic_1944 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RSc1603 probable dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. (593 aa) | ||||
Rpic_1946 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (557 aa) | ||||
Rpic_1947 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (896 aa) | ||||
folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) | ||||
Rpic_2037 | TIGRFAM: propionate/CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: rso:RSc1518 PrpE protein ligase (putative propionyl-CoA synthetase). (633 aa) | ||||
purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa) | ||||
acsA | acetate/CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) | ||||
Rpic_2102 | Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) | ||||
accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) | ||||
Rpic_2146 | KEGG: rso:RSc1991 type II citrate synthase; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (433 aa) | ||||
Rpic_2148 | KEGG: rso:RSc1993 succinate dehydrogenase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (233 aa) | ||||
Rpic_2149 | KEGG: rso:RSc1994 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (592 aa) | ||||
Rpic_2150 | TIGRFAM: succinate dehydrogenase, hydrophobic membrane anchor protein; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: rso:RSc1995 putative transmembrane succinate dehydrogenase (hydrophobic membrane anchor subunit) oxidoreductase protein. (121 aa) | ||||
Rpic_2151 | TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: rso:RSc1996 putative transmembrane succinate dehydrogenase (cytochrome b-556 subunit) oxidoreductase protein. (136 aa) | ||||
mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa) | ||||
prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (298 aa) | ||||
Rpic_2157 | Hypothetical protein; KEGG: rso:RSc2002 2-methylcitrate dehydratase. (132 aa) | ||||
Rpic_2158 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) | ||||
Rpic_2263 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic protein domain protein; malic protein NAD-binding; KEGG: rso:RSc2123 malic enzyme. (773 aa) | ||||
Rpic_2513 | TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: bte:BTH_II0362 succinate dehydrogenase, iron-sulfur protein. (235 aa) | ||||
Rpic_2549 | KEGG: rme:Rmet_4488 hypothetical protein. (294 aa) | ||||
Rpic_2566 | PFAM: Aldehyde Dehydrogenase_; KEGG: rso:RSc2350 probable aldehyde dehydrogenase oxidoreductase protein; Belongs to the aldehyde dehydrogenase family. (478 aa) | ||||
Rpic_2583 | TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: rso:RSc2370 hypothetical protein. (387 aa) | ||||
Rpic_2585 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: rso:RSc2372 probable formate dehydrogenase (iron-sulfur subunit) oxidoreductase protein. (222 aa) | ||||
Rpic_2586 | PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: rso:RSc2373 probable formate dehydrogenase (large subunit) oxidoreductase protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1001 aa) | ||||
Rpic_2752 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rso:RSc2490 isocitrate dehydrogenase. (416 aa) | ||||
Rpic_3031 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (155 aa) | ||||
Rpic_3032 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (455 aa) | ||||
Rpic_3133 | TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rso:RSc2891 putative oxidoreductase protein. (338 aa) | ||||
gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (375 aa) | ||||
gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa) | ||||
gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (979 aa) | ||||
Rpic_3564 | TIGRFAM: DNA binding domain protein, excisionase family; PFAM: regulatory protein MerR; Citrate synthase; KEGG: dac:Daci_4908 citrate synthase. (410 aa) | ||||
Rpic_3721 | TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; KEGG: rso:RSc0029 probable 4-aminobutyrate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (426 aa) | ||||
Rpic_3722 | TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: rso:RSc0028 probable succinate-semialdehyde dehydrogenase oxidoreductase protein; Belongs to the aldehyde dehydrogenase family. (500 aa) | ||||
Rpic_3858 | TIGRFAM: AcnD-accessory protein PrpF; PFAM: protein of unknown function DUF453; KEGG: rso:RS03003 hypothetical protein. (395 aa) | ||||
Rpic_3859 | KEGG: rso:RSp0120 aconitate hydratase; TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; PFAM: aconitate hydratase domain protein. (865 aa) | ||||
Rpic_3860 | KEGG: rso:RSp0121 methylcitrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family. (389 aa) | ||||
prpB-2 | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (298 aa) | ||||
Rpic_3897 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: rso:RS02078 mercuric reductase. (459 aa) | ||||
Rpic_3974 | PFAM: AMP-dependent synthetase and ligase; KEGG: rso:RS05571 probable acetyl-coenzyme A synthetase (acetate--CoA ligase) protein. (564 aa) | ||||
Rpic_3975 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: rso:RSp0650 probable methylmalonate-semialdehyde dehydrogenase oxidoreductase protein. (515 aa) | ||||
Rpic_3976 | KEGG: rso:RSp0649 probable 3-hydroxyisobutyrate dehydrogenase oxidoreductase protein; TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; Belongs to the HIBADH-related family. (297 aa) | ||||
Rpic_4041 | KEGG: rme:Rmet_4144 citrate synthase. (284 aa) | ||||
Rpic_4109 | Alkane 1-monooxygenase; PFAM: fatty acid desaturase; KEGG: bch:Bcen2424_0980 alkane 1-monooxygenase. (387 aa) | ||||
fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) | ||||
Rpic_4143 | PFAM: AMP-dependent synthetase and ligase; KEGG: rso:RS05310 probable acetyl-coenzyme A synthetase (acetate--CoA ligase) protein. (565 aa) | ||||
Rpic_4273 | PFAM: aminotransferase class-III; KEGG: rso:RS02393 beta alanine--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) | ||||
Rpic_4274 | TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: rso:RS02392 probable transmembrane aldehyde dehydrogenase oxidoreductase protein. (507 aa) | ||||
Rpic_4318 | TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: bur:Bcep18194_C6772 succinic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (499 aa) | ||||
Rpic_4350 | KEGG: rme:Rmet_4488 hypothetical protein. (293 aa) | ||||
Rpic_4356 | TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: rso:RSc1996 putative transmembrane succinate dehydrogenase (cytochrome b-556 subunit) oxidoreductase protein. (158 aa) | ||||
Rpic_4357 | TIGRFAM: succinate dehydrogenase, hydrophobic membrane anchor protein; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: rso:RSc1995 putative transmembrane succinate dehydrogenase (hydrophobic membrane anchor subunit) oxidoreductase protein. (121 aa) | ||||
Rpic_4358 | KEGG: rso:RSc1994 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (592 aa) | ||||
Rpic_4359 | KEGG: rso:RSc1993 succinate dehydrogenase iron-sulfur subunit; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin. (233 aa) | ||||
Rpic_4391 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: sen:SACE_2432 formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (886 aa) | ||||
Rpic_4392 | PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: swi:Swit_1474 NADH dehydrogenase (quinone). (525 aa) | ||||
Rpic_4437 | TIGRFAM: zinc-binding alcohol dehydrogenase family protein; PFAM: Alcohol dehydrogenase GroES domain protein; KEGG: rso:RSc1505 probable alcohol dehydrogenase-like oxidoreductase protein. (336 aa) | ||||
Rpic_4479 | TIGRFAM: aconitate hydratase 2; PFAM: aconitate hydratase domain protein; Aconitase B, N-terminal; KEGG: bch:Bcen2424_4695 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (861 aa) | ||||
Rpic_4553 | TIGRFAM: aconitate hydratase 2; PFAM: aconitate hydratase domain protein; Aconitase B, N-terminal; KEGG: bch:Bcen2424_4695 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (861 aa) | ||||
Rpic_4642 | TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: sen:SACE_2432 formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (886 aa) | ||||
Rpic_4643 | PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: swi:Swit_1474 NADH dehydrogenase (quinone). (480 aa) | ||||
Rpic_4644 | PFAM: AMP-dependent synthetase and ligase; KEGG: bte:BTH_II0927 acetyl-CoA synthetase. (588 aa) | ||||
pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (341 aa) | ||||
Rpic_4646 | Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa) | ||||
Rpic_4647 | PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: bte:BTH_II0930 probable pyruvate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase. (375 aa) |