(59 nodes) Homologous recombination network (Penicillium italicum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PITC_075590	Nucleic acid-binding, OB-fold. (290 aa)
	PITC_049390	CWC16 protein. (283 aa)
	PITC_012660	DNA-directed DNA polymerase, family X, beta-like, N-terminal. (589 aa)
	PITC_012910	Uncharacterized protein. (288 aa)
	PITC_087400	Uncharacterized protein. (219 aa)
	PITC_086850	Tetratricopeptide-like helical. (485 aa)
	PITC_022890	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family. (1526 aa)
	PITC_049350	Uncharacterized protein. (258 aa)
	PITC_073890	Nucleic acid-binding, OB-fold. (118 aa)
	PITC_073600	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2818 aa)
	PITC_012730	Uncharacterized protein. (507 aa)
	PITC_022460	Integrase, catalytic core. (775 aa)
	PITC_018720	DNA polymerase subunit Cdc27. (461 aa)
	PITC_094530	Reverse transcriptase, RNA-dependent DNA polymerase. (82 aa)
	PITC_063750	Uncharacterized protein. (790 aa)
	PITC_022450	Reverse transcriptase, RNA-dependent DNA polymerase. (348 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (720 aa)
	PITC_063960	Zinc finger, RING-type. (201 aa)
	PITC_029000	DNA recombination and repair protein RecA. (390 aa)
	PITC_018680	DNA polymerase. (1104 aa)
	PITC_046900	Fido domain-containing protein. (351 aa)
	PITC_095640	Activator of mitotic machinery Cdc14 phosphatase activation C-terminal. (866 aa)
	PITC_071010	Rad52/22 double-strand break repair protein. (606 aa)
	PITC_071310	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (497 aa)
	PITC_043200	NIBRIN_BRCT_II domain-containing protein. (659 aa)
	PITC_095100	Integrase, catalytic core. (1847 aa)
	PITC_046510	Uncharacterized protein. (264 aa)
	PITC_051870	Uncharacterized protein. (194 aa)
	PITC_027650	Uncharacterized protein. (146 aa)
	PITC_028500	Uncharacterized protein. (123 aa)
	PITC_057300	DNA recombination and repair protein Rad51, C-terminal. (526 aa)
	PITC_050560	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
	PITC_085810	Helicase, C-terminal. (811 aa)
	PITC_086320	Recombination/repair protein Rad50. (1317 aa)
	PITC_056320	Smr domain-containing protein. (251 aa)
	PITC_039150	Rad51 domain-containing protein. (441 aa)
	PITC_062320	Uncharacterized protein. (565 aa)
	PITC_019250	ERCC4 domain-containing protein. (667 aa)
	PITC_019300	Uncharacterized protein. (399 aa)
	PITC_016920	Uncharacterized protein. (595 aa)
	PITC_032170	Helicase, C-terminal. (723 aa)
	PITC_082770	Uncharacterized protein. (81 aa)
	PITC_032730	Uncharacterized protein. (88 aa)
	PITC_036950	HD domain-containing protein. (235 aa)
	PITC_062340	Uncharacterized protein. (234 aa)
	PITC_091760	Helicase, C-terminal. (1500 aa)
	PITC_088800	Uncharacterized protein. (383 aa)
	PITC_092590	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (628 aa)
	PITC_024650	Primosome PriB/single-strand DNA-binding. (144 aa)
	PITC_041280	Uncharacterized protein. (97 aa)
	PITC_040420	Uncharacterized protein. (107 aa)
	PITC_041200	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (344 aa)
	PITC_010550	DNA polymerase delta/II small subunit family. (544 aa)
	PITC_040690	Helicase, C-terminal. (1502 aa)
	PITC_046940	Helicase, C-terminal. (1406 aa)
	PITC_036360	Winged helix-turn-helix transcription repressor DNA-binding. (278 aa)
	PITC_017750	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (208 aa)
	PITC_017850	DNA polymerase delta, subunit 4. (182 aa)
	PITC_024320	Uncharacterized protein. (251 aa)

Your Current Organism:

Penicillium italicum

NCBI taxonomy Id: 40296
Other names: CBS 339.48, P. italicum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIF1	PITC_012660	A0A0A2KKZ8	A0A0A2K880	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA-directed DNA polymerase, family X, beta-like, N-terminal.	0.678
PIF1	PITC_018680	A0A0A2KKZ8	A0A0A2KMH4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA polymerase.	0.500
PIF1	PITC_018720	A0A0A2KKZ8	A0A0A2KCL8	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA polymerase subunit Cdc27.	0.632
PIF1	PITC_022890	A0A0A2KKZ8	A0A0A2K9C5	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Mre11, DNA-binding; Belongs to the MRE11/RAD32 family.	0.619
PIF1	PITC_024650	A0A0A2KKZ8	A0A0A2LCU3	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Primosome PriB/single-strand DNA-binding.	0.519
PIF1	PITC_029000	A0A0A2KKZ8	A0A0A2KM27	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA recombination and repair protein RecA.	0.431
PIF1	PITC_036360	A0A0A2KKZ8	A0A0A2LI81	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Winged helix-turn-helix transcription repressor DNA-binding.	0.434
PIF1	PITC_040690	A0A0A2KKZ8	A0A0A2LFV1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Helicase, C-terminal.	0.482
PIF1	PITC_041200	A0A0A2KKZ8	A0A0A2LDW5	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.806
PIF1	PITC_046510	A0A0A2KKZ8	A0A0A2KST4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.410
PIF1	PITC_050560	A0A0A2KKZ8	A0A0A2KZF8	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.719
PIF1	PITC_057300	A0A0A2KKZ8	A0A0A2KYA4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	DNA recombination and repair protein Rad51, C-terminal.	0.491
PIF1	PITC_071010	A0A0A2KKZ8	A0A0A2KNL4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Rad52/22 double-strand break repair protein.	0.886
PIF1	PITC_071310	A0A0A2KKZ8	A0A0A2KNP6	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.747
PIF1	PITC_073600	A0A0A2KKZ8	A0A0A2KA99	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.517
PIF1	PITC_075590	A0A0A2KKZ8	A0A0A2KYZ6	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Nucleic acid-binding, OB-fold.	0.420
PIF1	PITC_085810	A0A0A2KKZ8	A0A0A2KZP4	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Helicase, C-terminal.	0.482
PIF1	PITC_086320	A0A0A2KKZ8	A0A0A2KZY6	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Recombination/repair protein Rad50.	0.680
PIF1	PITC_088800	A0A0A2KKZ8	A0A0A2LB98	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Uncharacterized protein.	0.410
PIF1	PITC_091760	A0A0A2KKZ8	A0A0A2LAG7	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.	Helicase, C-terminal.	0.747