STRINGSTRING
AJE43220.1 AJE43220.1 AJE43209.1 AJE43209.1 AJE43188.1 AJE43188.1 AJE43079.1 AJE43079.1 AJE42959.1 AJE42959.1 AJE42945.1 AJE42945.1 tdk tdk AJE42918.1 AJE42918.1 AJE42905.1 AJE42905.1 AJE42898.1 AJE42898.1 AJE42892.1 AJE42892.1 lexA lexA recA recA AJE42851.1 AJE42851.1 mutM mutM AJE42709.1 AJE42709.1 ligA ligA nucS nucS AJE42513.1 AJE42513.1 AJE38917.1 AJE38917.1 AJE39128.1 AJE39128.1 AJE39195.1 AJE39195.1 AJE39244.1 AJE39244.1 AJE39251.1 AJE39251.1 AJE39252.1 AJE39252.1 AJE39398.1 AJE39398.1 AJE39432.1 AJE39432.1 AJE39446.1 AJE39446.1 AJE39474.1 AJE39474.1 ligB ligB AJE39561.1 AJE39561.1 AJE39600.1 AJE39600.1 ung ung dinB dinB AJE39665.1 AJE39665.1 AJE39700.1 AJE39700.1 priA priA AJE39745.1 AJE39745.1 ruvB ruvB ruvA ruvA ruvC ruvC AJE39853.1 AJE39853.1 AJE39885.1 AJE39885.1 AJE39897.1 AJE39897.1 AJE39912.1 AJE39912.1 AJE39931.1 AJE39931.1 AJE39945.1 AJE39945.1 AJE39963.1 AJE39963.1 AJE39964.1 AJE39964.1 AJE39989.1 AJE39989.1 AJE39995.1 AJE39995.1 AJE40005.1 AJE40005.1 AJE40084.1 AJE40084.1 cas1 cas1 AJE40087.1 AJE40087.1 AJE40106.1 AJE40106.1 AJE40107.1 AJE40107.1 uvrC uvrC uvrA uvrA uvrB uvrB AJE40188.1 AJE40188.1 AJE40198.1 AJE40198.1 polA polA AJE40264.1 AJE40264.1 nfo nfo AJE40388.1 AJE40388.1 AJE40452.1 AJE40452.1 AJE40462.1 AJE40462.1 dnaG dnaG recO recO dnaJ dnaJ AJE40627.1 AJE40627.1 AJE40633.1 AJE40633.1 AJE40667.1 AJE40667.1 AJE40692.1 AJE40692.1 AJE40749.1 AJE40749.1 ku ku recD2 recD2 AJE40858.1 AJE40858.1 AJE40966.1 AJE40966.1 AJE40995.1 AJE40995.1 mfd mfd AJE41099.1 AJE41099.1 AJE41117.1 AJE41117.1 AJE41168.1 AJE41168.1 AJE41179.1 AJE41179.1 AJE41223.1 AJE41223.1 AJE41251.1 AJE41251.1 AJE41339.1 AJE41339.1 AJE41349.1 AJE41349.1 AJE41375.1 AJE41375.1 AJE41420.1 AJE41420.1 AJE41430.1 AJE41430.1 AJE41435.1 AJE41435.1 AJE41471.1 AJE41471.1 AJE41472.1 AJE41472.1 AJE41510.1 AJE41510.1 AJE41528.1 AJE41528.1 AJE41532.1 AJE41532.1 dnaA dnaA AJE41558.1 AJE41558.1 recF recF gyrB gyrB gyrA gyrA AJE41592.1 AJE41592.1 AJE41671.1 AJE41671.1 dnaJ-2 dnaJ-2 recR recR AJE41736.1 AJE41736.1 nth nth AJE41755.1 AJE41755.1 topA topA AJE41773.1 AJE41773.1 AJE41777.1 AJE41777.1 AJE41829.1 AJE41829.1 AJE41839.1 AJE41839.1 disA disA radA radA AJE41935.1 AJE41935.1 xseB xseB xseA xseA AJE42323.1 AJE42323.1 AJE42349.1 AJE42349.1 AJE42364.1 AJE42364.1 AJE42380.1 AJE42380.1 AJE42400.1 AJE42400.1 AJE42436.1 AJE42436.1 AJE42437.1 AJE42437.1 AJE42463.1 AJE42463.1 AJE42506.1 AJE42506.1 AJE42507.1 AJE42507.1 AJE38675.1 AJE38675.1 AJE38803.1 AJE38803.1 AJE38797.1 AJE38797.1 AJE44515.1 AJE44515.1 AJE38792.1 AJE38792.1 AJE38791.1 AJE38791.1 AJE38790.1 AJE38790.1 AJE38783.1 AJE38783.1 AJE38781.1 AJE38781.1 AJE38767.1 AJE38767.1 AJE38724.1 AJE38724.1 AJE38705.1 AJE38705.1 AJE38704.1 AJE38704.1 AJE38699.1 AJE38699.1 AJE44514.1 AJE44514.1 AJE38696.1 AJE38696.1 AJE38914.1 AJE38914.1 AJE38913.1 AJE38913.1 AJE38879.1 AJE38879.1 AJE38677.1 AJE38677.1 AJE44513.1 AJE44513.1 AJE44511.1 AJE44511.1 AJE44496.1 AJE44496.1 AJE44495.1 AJE44495.1 AJE44478.1 AJE44478.1 AJE44477.1 AJE44477.1 AJE44422.1 AJE44422.1 AJE44343.1 AJE44343.1 AJE44335.1 AJE44335.1 AJE44110.1 AJE44110.1 AJE44106.1 AJE44106.1 ku-2 ku-2 AJE43967.1 AJE43967.1 rlmG rlmG AJE43949.1 AJE43949.1 AJE43948.1 AJE43948.1 ung-2 ung-2 AJE43904.1 AJE43904.1 AJE43842.1 AJE43842.1 AJE44521.1 AJE44521.1 AJE43763.1 AJE43763.1 AJE43618.1 AJE43618.1 AJE43617.1 AJE43617.1 AJE43597.1 AJE43597.1 AJE43596.1 AJE43596.1 AJE43594.1 AJE43594.1 AJE43538.1 AJE43538.1 AJE43518.1 AJE43518.1 AJE43517.1 AJE43517.1 AJE43462.1 AJE43462.1 AJE43461.1 AJE43461.1 AJE43460.1 AJE43460.1 AJE43459.1 AJE43459.1 AJE43444.1 AJE43444.1 AJE43443.1 AJE43443.1 AJE43334.1 AJE43334.1 AJE43333.1 AJE43333.1 AJE43332.1 AJE43332.1 AJE43323.1 AJE43323.1 AJE43224.1 AJE43224.1 AJE43221.1 AJE43221.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE43220.1DNA-3-methyladenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
AJE43209.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
AJE43188.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
AJE43079.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (79 aa)
AJE42959.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (75 aa)
AJE42945.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AJE42918.1DNA topoisomerase IV subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (819 aa)
AJE42905.1DNA topoisomerase IV subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (707 aa)
AJE42898.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (718 aa)
AJE42892.1Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (961 aa)
lexALexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (259 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (376 aa)
AJE42851.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (291 aa)
AJE42709.1Cell division initiation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
ligANAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (730 aa)
nucSEndonuclease; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (223 aa)
AJE42513.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
AJE38917.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
AJE39128.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
AJE39195.1ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (778 aa)
AJE39244.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
AJE39251.1DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AJE39252.1Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (205 aa)
AJE39398.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (816 aa)
AJE39432.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
AJE39446.1DNA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (286 aa)
AJE39474.1N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (551 aa)
ligBATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (512 aa)
AJE39561.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
AJE39600.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (483 aa)
AJE39665.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (516 aa)
AJE39700.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (719 aa)
AJE39745.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
ruvBATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (356 aa)
ruvAATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (201 aa)
ruvCHolliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (176 aa)
AJE39853.15'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
AJE39885.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE39897.1Phosphatidylinositol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
AJE39912.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (581 aa)
AJE39931.1Serine-threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
AJE39945.1DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AJE39963.1DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-Y family. (324 aa)
AJE39964.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1163 aa)
AJE39989.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AJE39995.1DNA recombination protein RecN; May be involved in recombinational repair of damaged DNA. (572 aa)
AJE40005.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA glycosylase MPG family. (213 aa)
AJE40084.1CRISPR-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (324 aa)
AJE40087.1CRISPR-associated protein Cas2; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
AJE40106.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AJE40107.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (676 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1009 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (712 aa)
AJE40188.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (184 aa)
AJE40198.1uracil-DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (240 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (907 aa)
AJE40264.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1179 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (274 aa)
AJE40388.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJE40452.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
AJE40462.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (634 aa)
recODNA recombination protein RecO; Involved in DNA repair and RecF pathway recombination. (248 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (379 aa)
AJE40627.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AJE40633.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
AJE40667.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE40692.1DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPG family. (269 aa)
AJE40749.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
kuDNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (390 aa)
recD2Helicase; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (759 aa)
AJE40858.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
AJE40966.1Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
AJE40995.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1179 aa)
AJE41099.1AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
AJE41117.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AJE41168.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
AJE41179.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE41223.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
AJE41251.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
AJE41339.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE41349.1Fatty acid-binding protein; May play a role in the intracellular transport of hydrophobic ligands. (191 aa)
AJE41375.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AJE41420.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
AJE41430.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AJE41435.1Daunorubicin resistance protein DrrC; Derived by automated computational analysis using gene prediction method: Protein Homology. (800 aa)
AJE41471.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
AJE41472.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJE41510.1Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AJE41528.1Helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (491 aa)
AJE41532.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
dnaAChromosomal replication initiation protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (605 aa)
AJE41558.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
recFRecombinase RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (373 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (695 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (865 aa)
AJE41592.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
AJE41671.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
dnaJ-2Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (391 aa)
recRRecombinase RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa)
AJE41736.1Hypothetical protein; Required for the transposition of the insertion element. (105 aa)
nthEndonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (375 aa)
AJE41755.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (943 aa)
AJE41773.1DNA polymerase III subunit delta; Catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJE41777.13'-5' exonuclease; Similar to DNA polymerase I; lacks 5'-3' exonuclease domain; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
AJE41829.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
AJE41839.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
disADNA integrity scanning protein DisA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (374 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (469 aa)
AJE41935.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (647 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (406 aa)
AJE42323.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (60 aa)
AJE42349.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
AJE42364.13-methyladenine DNA glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
AJE42380.1Phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
AJE42400.1Helicase UvrD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily. (1061 aa)
AJE42436.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa)
AJE42437.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (791 aa)
AJE42463.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AJE42506.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AJE42507.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AJE38675.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
AJE38803.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
AJE38797.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AJE44515.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AJE38792.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AJE38791.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AJE38790.1DDE endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AJE38783.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AJE38781.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
AJE38767.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AJE38724.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
AJE38705.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa)
AJE38704.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AJE38699.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AJE44514.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJE38696.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AJE38914.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJE38913.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
AJE38879.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
AJE38677.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AJE44513.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (83 aa)
AJE44511.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (531 aa)
AJE44496.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
AJE44495.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (297 aa)
AJE44478.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (110 aa)
AJE44477.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AJE44422.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AJE44343.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (75 aa)
AJE44335.1Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
AJE44110.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AJE44106.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (995 aa)
ku-2DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (322 aa)
AJE43967.1DNA repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
rlmG50S rRNA methyltransferase; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (386 aa)
AJE43949.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
AJE43948.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
ung-2uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa)
AJE43904.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
AJE43842.1DNA gyrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
AJE44521.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
AJE43763.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
AJE43618.1DDE endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AJE43617.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
AJE43597.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (108 aa)
AJE43596.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
AJE43594.1Mobile element protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
AJE43538.1MarR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
AJE43518.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AJE43517.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
AJE43462.1N-6 DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
AJE43461.1Restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (663 aa)
AJE43460.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
AJE43459.1Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology. (1061 aa)
AJE43444.1Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
AJE43443.1Cytoplasmic protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
AJE43334.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (707 aa)
AJE43333.1Restriction endonuclease subunit M; Derived by automated computational analysis using gene prediction method: Protein Homology. (694 aa)
AJE43332.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AJE43323.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
AJE43224.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (664 aa)
AJE43221.1Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (160 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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