STRINGSTRING
AJE40511.1 AJE40511.1 AJE40531.1 AJE40531.1 AJE40566.1 AJE40566.1 AJE40612.1 AJE40612.1 AJE40617.1 AJE40617.1 AJE40619.1 AJE40619.1 nadD nadD ndk ndk AJE40743.1 AJE40743.1 AJE40833.1 AJE40833.1 AJE40879.1 AJE40879.1 AJE40894.1 AJE40894.1 AJE40895.1 AJE40895.1 AJE40919.1 AJE40919.1 AJE40980.1 AJE40980.1 manA manA AJE40986.1 AJE40986.1 AJE41003.1 AJE41003.1 AJE41005.1 AJE41005.1 AJE41007.1 AJE41007.1 purE purE purK purK AJE41042.1 AJE41042.1 eno eno AJE41057.1 AJE41057.1 glmU glmU prs prs AJE41122.1 AJE41122.1 AJE41126.1 AJE41126.1 purU purU mqnB mqnB AJE41262.1 AJE41262.1 gpmA gpmA AJE41367.1 AJE41367.1 purM purM purF purF purQ purQ purS purS purC purC purD purD upp upp AJE41523.1 AJE41523.1 AJE41600.1 AJE41600.1 AJE41602.1 AJE41602.1 AJE41611.1 AJE41611.1 AJE41613.1 AJE41613.1 dcd dcd AJE41674.1 AJE41674.1 AJE41678.1 AJE41678.1 pyrE pyrE AJE41701.1 AJE41701.1 kynU kynU purA purA AJE41749.1 AJE41749.1 acsA acsA AJE41788.1 AJE41788.1 AJE41803.1 AJE41803.1 AJE41824.1 AJE41824.1 coaX coaX AJE41977.1 AJE41977.1 adk adk glmM glmM coaA coaA nnrE nnrE guaB guaB AJE42073.1 AJE42073.1 guaA guaA sucC sucC purN purN purH purH folD-2 folD-2 AJE42173.1 AJE42173.1 AJE42174.1 AJE42174.1 add add AJE42189.1 AJE42189.1 AJE42197.1 AJE42197.1 AJE42208.1 AJE42208.1 AJE42213.1 AJE42213.1 AJE42216.1 AJE42216.1 AJE42402.1 AJE42402.1 AJE42436.1 AJE42436.1 AJE42458.1 AJE42458.1 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC AJE42579.1 AJE42579.1 ackA ackA AJE42581.1 AJE42581.1 pfkA-2 pfkA-2 AJE42628.1 AJE42628.1 coaD coaD pyrH pyrH AJE42782.1 AJE42782.1 AJE42812.1 AJE42812.1 thyX thyX AJE42848.1 AJE42848.1 AJE42884.1 AJE42884.1 AJE42895.1 AJE42895.1 tdk tdk AJE42928.1 AJE42928.1 dut dut AJE42978.1 AJE42978.1 AJE43019.1 AJE43019.1 AJE43098.1 AJE43098.1 cmk cmk AJE43170.1 AJE43170.1 AJE43206.1 AJE43206.1 AJE43247.1 AJE43247.1 AJE43361.1 AJE43361.1 AJE43442.1 AJE43442.1 AJE43468.1 AJE43468.1 AJE43491.1 AJE43491.1 AJE43523.1 AJE43523.1 AJE43566.1 AJE43566.1 AJE43595.1 AJE43595.1 AJE43614.1 AJE43614.1 AJE43667.1 AJE43667.1 AJE43670.1 AJE43670.1 AJE38745.1 AJE38745.1 AJE38782.1 AJE38782.1 folD folD purU-2 purU-2 AJE38923.1 AJE38923.1 AJE39039.1 AJE39039.1 AJE39042.1 AJE39042.1 AJE39045.1 AJE39045.1 amphDIII amphDIII AJE39092.1 AJE39092.1 AJE39110.1 AJE39110.1 eno-2 eno-2 AJE44480.1 AJE44480.1 AJE44443.1 AJE44443.1 AJE44371.1 AJE44371.1 AJE44332.1 AJE44332.1 AJE44329.1 AJE44329.1 AJE44308.1 AJE44308.1 AJE44259.1 AJE44259.1 psuG psuG nadK nadK AJE44131.1 AJE44131.1 add-2 add-2 AJE43984.1 AJE43984.1 AJE43950.1 AJE43950.1 AJE43928.1 AJE43928.1 AJE43886.1 AJE43886.1 AJE43841.1 AJE43841.1 AJE43838.1 AJE43838.1 AJE43787.1 AJE43787.1 AJE39238.1 AJE39238.1 AJE39271.1 AJE39271.1 AJE39380.1 AJE39380.1 AJE39383.1 AJE39383.1 AJE39486.1 AJE39486.1 AJE39511.1 AJE39511.1 pfkA pfkA AJE39560.1 AJE39560.1 AJE39635.1 AJE39635.1 AJE39656.1 AJE39656.1 AJE39685.1 AJE39685.1 AJE39707.1 AJE39707.1 AJE39718.1 AJE39718.1 gmk gmk pyrD pyrD carB carB carA carA AJE39725.1 AJE39725.1 pyrC pyrC pyrB pyrB AJE39751.1 AJE39751.1 apt apt AJE39768.1 AJE39768.1 AJE39989.1 AJE39989.1 pyrG pyrG ppnK ppnK pgi pgi tpiA tpiA pgk pgk AJE40167.1 AJE40167.1 AJE40190.1 AJE40190.1 AJE40220.1 AJE40220.1 AJE40221.1 AJE40221.1 AJE40271.1 AJE40271.1 pfp pfp AJE40322.1 AJE40322.1 nadA nadA AJE40367.1 AJE40367.1 AJE40368.1 AJE40368.1 AJE40370.1 AJE40370.1 AJE40499.1 AJE40499.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE40511.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
AJE40531.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
AJE40566.1Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
AJE40612.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
AJE40617.1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (330 aa)
AJE40619.1Histidine triad (HIT) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (220 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
AJE40743.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
AJE40833.1Peptidase M6; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
AJE40879.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (200 aa)
AJE40894.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (433 aa)
AJE40895.1Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
AJE40919.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (189 aa)
AJE40980.1acetyl-CoA carboxyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
manAMannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AJE40986.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AJE41003.1acyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
AJE41005.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AJE41007.1UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (391 aa)
AJE41042.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (301 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
AJE41057.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (482 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
AJE41122.1UTP--glucose-1-phosphate uridylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AJE41126.1Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (277 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (293 aa)
mqnBFutalosine nucleosidase; Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2). (228 aa)
AJE41262.1Glucosyl-3-phosphoglycerate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
AJE41367.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (596 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (508 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (87 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (418 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
AJE41523.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AJE41600.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AJE41602.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
AJE41611.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJE41613.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
AJE41674.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
AJE41678.1GDP-D-mannose dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (175 aa)
AJE41701.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (400 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
AJE41749.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJE41788.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
AJE41803.1Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
AJE41824.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (325 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (265 aa)
AJE41977.1Adenine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (220 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (452 aa)
coaAPantothenate kinase; Catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
nnrECarbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (483 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa)
AJE42073.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (529 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (528 aa)
folD-2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
AJE42173.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
AJE42174.1Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (383 aa)
AJE42189.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
AJE42197.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (299 aa)
AJE42208.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
AJE42213.1Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (206 aa)
AJE42216.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AJE42402.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
AJE42436.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (340 aa)
AJE42458.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
atpBATP synthase F0F1 subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (256 aa)
atpEATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (80 aa)
atpFATP synthase F0F1 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (183 aa)
atpHATP synthase F0F1 subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (271 aa)
atpAATP synthase F0F1 subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (530 aa)
atpGATP synthase F0F1 subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (305 aa)
atpDATP F0F1 synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (478 aa)
atpCATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (124 aa)
AJE42579.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
AJE42581.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE42628.1TesB-like acyl-CoA thioesterase 3; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (252 aa)
AJE42782.1GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
AJE42812.1Riboflavin kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (316 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
AJE42848.1Damage-inducible protein CinA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (181 aa)
AJE42884.1Kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
AJE42895.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (230 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
AJE42928.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (171 aa)
AJE42978.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
AJE43019.1Nucleotide pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AJE43098.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
AJE43170.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJE43206.1Phenylhydantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
AJE43247.1Deoxyribose-phosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJE43361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
AJE43442.1Metalloenzyme domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AJE43468.16-pyruvoyl tetrahydropterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AJE43491.1ATP-grasp domain protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AJE43523.1Hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AJE43566.1Flavin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
AJE43595.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
AJE43614.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)
AJE43667.1dTDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (327 aa)
AJE43670.1dTDP-4-dehydrorhamnose 3,5-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AJE38745.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
AJE38782.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
folD5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (302 aa)
AJE38923.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AJE39039.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AJE39042.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
AJE39045.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
amphDIIIAmphDIII GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (344 aa)
AJE39092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AJE39110.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa)
AJE44480.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
AJE44443.1Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
AJE44371.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AJE44332.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1485 aa)
AJE44329.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AJE44308.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AJE44259.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (316 aa)
psuGPseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (303 aa)
nadKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (354 aa)
AJE44131.1Fructose transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
add-2Adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (356 aa)
AJE43984.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
AJE43950.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
AJE43928.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJE43886.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
AJE43841.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AJE43838.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AJE43787.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
AJE39238.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
AJE39271.1Flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
AJE39380.1UDP-glucose 6-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
AJE39383.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AJE39486.1Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
AJE39511.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE39560.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
AJE39635.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
AJE39656.1acetoacetyl-CoA synthetase; AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
AJE39685.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
AJE39707.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AJE39718.1Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (177 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1102 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (385 aa)
AJE39725.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (343 aa)
AJE39751.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (843 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (179 aa)
AJE39768.1HIT family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
AJE39989.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (562 aa)
ppnKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (301 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (551 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
AJE40167.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
AJE40190.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
AJE40220.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
AJE40221.1Nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (607 aa)
AJE40271.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AJE40322.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (394 aa)
AJE40367.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (81 aa)
AJE40368.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
AJE40370.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AJE40499.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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