STRINGSTRING
AJE40772.1 AJE40772.1 AJE38755.1 AJE38755.1 AJE38762.1 AJE38762.1 AJE38927.1 AJE38927.1 AJE38932.1 AJE38932.1 AJE38935.1 AJE38935.1 AJE39012.1 AJE39012.1 AJE39019.1 AJE39019.1 AJE39092.1 AJE39092.1 AJE39504.1 AJE39504.1 bioB bioB AJE39707.1 AJE39707.1 AJE39711.1 AJE39711.1 pyrD pyrD pdxS pdxS moaA moaA AJE40115.1 AJE40115.1 AJE40118.1 AJE40118.1 dapA dapA tal tal tpiA tpiA AJE40230.1 AJE40230.1 trpA trpA trpC trpC hisF hisF priA-2 priA-2 thiE thiE thiG thiG AJE40313.1 AJE40313.1 AJE40364.1 AJE40364.1 lipA lipA AJE40459.1 AJE40459.1 AJE40575.1 AJE40575.1 leuA leuA AJE40623.1 AJE40623.1 AJE40628.1 AJE40628.1 AJE40793.1 AJE40793.1 AJE40894.1 AJE40894.1 fbiC fbiC AJE41701.1 AJE41701.1 AJE41824.1 AJE41824.1 AJE41869.1 AJE41869.1 mqnE mqnE mqnC mqnC guaB guaB AJE42073.1 AJE42073.1 AJE42162.1 AJE42162.1 AJE42197.1 AJE42197.1 AJE42484.1 AJE42484.1 AJE42512.1 AJE42512.1 AJE42669.1 AJE42669.1 rlmN rlmN dapA-2 dapA-2 AJE42966.1 AJE42966.1 AJE43029.1 AJE43029.1 AJE43150.1 AJE43150.1 AJE43247.1 AJE43247.1 AJE43276.1 AJE43276.1 AJE43440.1 AJE43440.1 AJE43556.1 AJE43556.1 AJE43563.1 AJE43563.1 AJE43684.1 AJE43684.1 AJE43767.1 AJE43767.1 AJE43769.1 AJE43769.1 AJE43965.1 AJE43965.1 trpF trpF AJE44285.1 AJE44285.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE40772.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
AJE38755.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
AJE38762.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AJE38927.1Aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AJE38932.1Alpha-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (704 aa)
AJE38935.1Alpha-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
AJE39012.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (654 aa)
AJE39019.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
AJE39092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AJE39504.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (403 aa)
AJE39707.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AJE39711.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (368 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (303 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (329 aa)
AJE40115.1Dihydrodipicolinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (303 aa)
AJE40118.15-dehydro-4-deoxyglucarate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (313 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
AJE40230.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1536 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (269 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
priA-2Phosphoribosyl isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (243 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (222 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (264 aa)
AJE40313.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (451 aa)
AJE40364.1Endo alpha-1,4 polygalactosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
lipARadical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
AJE40459.1Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
AJE40575.1tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (383 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AJE40623.12-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
AJE40628.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (410 aa)
AJE40793.1hydroxymethylglutaryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
AJE40894.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (433 aa)
fbiCFO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (862 aa)
AJE41701.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
AJE41824.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (325 aa)
AJE41869.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (330 aa)
mqnERadical SAM protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (387 aa)
mqnCHypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (404 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (501 aa)
AJE42073.1Inosine-5-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AJE42162.1N-acetylneuraminate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
AJE42197.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (299 aa)
AJE42484.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJE42512.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (527 aa)
AJE42669.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
rlmNRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (368 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa)
AJE42966.14-hyroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (339 aa)
AJE43029.1Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (769 aa)
AJE43150.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
AJE43247.1Deoxyribose-phosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJE43276.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
AJE43440.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AJE43556.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
AJE43563.1Alpha-galactosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (703 aa)
AJE43684.11,2-oxophytodienoate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
AJE43767.1Glucose dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (319 aa)
AJE43769.1N-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (227 aa)
AJE43965.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
trpFPhosphoribosylanthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (199 aa)
AJE44285.11,2-oxophytodienoate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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