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AJE40370.1 AJE40370.1 AJE41701.1 AJE41701.1 acsA acsA AJE41950.1 AJE41950.1 AJE41951.1 AJE41951.1 AJE42196.1 AJE42196.1 pckG pckG AJE42301.1 AJE42301.1 AJE42306.1 AJE42306.1 AJE42314.1 AJE42314.1 AJE42579.1 AJE42579.1 pfkA-2 pfkA-2 AJE42766.1 AJE42766.1 AJE42780.1 AJE42780.1 AJE42895.1 AJE42895.1 AJE42924.1 AJE42924.1 AJE43044.1 AJE43044.1 AJE43048.1 AJE43048.1 AJE43148.1 AJE43148.1 AJE43170.1 AJE43170.1 AJE43183.1 AJE43183.1 AJE43247.1 AJE43247.1 AJE43295.1 AJE43295.1 AJE43305.1 AJE43305.1 AJE43361.1 AJE43361.1 AJE43489.1 AJE43489.1 AJE43768.1 AJE43768.1 AJE43877.1 AJE43877.1 AJE43942.1 AJE43942.1 AJE43965.1 AJE43965.1 AJE43968.1 AJE43968.1 AJE44112.1 AJE44112.1 AJE44186.1 AJE44186.1 AJE44259.1 AJE44259.1 AJE44307.1 AJE44307.1 AJE44308.1 AJE44308.1 AJE44372.1 AJE44372.1 AJE44377.1 AJE44377.1 AJE38696.1 AJE38696.1 AJE38928.1 AJE38928.1 AJE39026.1 AJE39026.1 AJE39092.1 AJE39092.1 AJE39098.1 AJE39098.1 AJE39110.1 AJE39110.1 eno-2 eno-2 AJE39253.1 AJE39253.1 AJE39283.1 AJE39283.1 AJE39330.1 AJE39330.1 AJE39405.1 AJE39405.1 AJE39505.1 AJE39505.1 pfkA pfkA AJE39563.1 AJE39563.1 AJE39584.1 AJE39584.1 AJE39653.1 AJE39653.1 AJE39899.1 AJE39899.1 AJE39939.1 AJE39939.1 AJE40106.1 AJE40106.1 pgi pgi tpiA tpiA pgk pgk AJE40167.1 AJE40167.1 AJE40207.1 AJE40207.1 AJE40220.1 AJE40220.1 pfp pfp AJE40322.1 AJE40322.1 AJE40366.1 AJE40366.1 AJE40531.1 AJE40531.1 AJE40548.1 AJE40548.1 AJE40573.1 AJE40573.1 AJE40644.1 AJE40644.1 AJE40720.1 AJE40720.1 AJE40724.1 AJE40724.1 AJE40761.1 AJE40761.1 AJE40847.1 AJE40847.1 AJE40986.1 AJE40986.1 AJE41030.1 AJE41030.1 AJE41042.1 AJE41042.1 eno eno AJE41266.1 AJE41266.1 gpmA gpmA AJE41420.1 AJE41420.1 AJE41600.1 AJE41600.1 AJE41601.1 AJE41601.1 AJE41602.1 AJE41602.1 AJE41611.1 AJE41611.1 AJE41612.1 AJE41612.1 AJE41613.1 AJE41613.1 AJE41699.1 AJE41699.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE40370.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AJE41701.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJE41950.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJE41951.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
AJE42196.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
AJE42301.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
AJE42306.1Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AJE42314.1PEP-utilizing protein mobile subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
AJE42579.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE42766.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AJE42780.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJE42895.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (230 aa)
AJE42924.1acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
AJE43044.1Alpha-mannosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1245 aa)
AJE43048.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
AJE43148.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
AJE43170.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJE43183.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AJE43247.1Deoxyribose-phosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJE43295.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
AJE43305.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
AJE43361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
AJE43489.16-phospho-beta-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AJE43768.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
AJE43877.1ROK family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE43942.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AJE43965.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
AJE43968.1Regulatory protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
AJE44112.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
AJE44186.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
AJE44259.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (316 aa)
AJE44307.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
AJE44308.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AJE44372.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
AJE44377.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
AJE38696.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AJE38928.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AJE39026.1Alpha-1,2-mannosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (774 aa)
AJE39092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AJE39098.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
AJE39110.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa)
AJE39253.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
AJE39283.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
AJE39330.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
AJE39405.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AJE39505.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE39563.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AJE39584.1Alpha-mannosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1093 aa)
AJE39653.1PTS glucose transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AJE39899.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
AJE39939.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (465 aa)
AJE40106.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (551 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (258 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (403 aa)
AJE40167.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
AJE40207.1Lytic transglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
AJE40220.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AJE40322.1Glucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AJE40366.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AJE40531.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
AJE40548.1Aldose epimerase; Converts alpha-aldose to the beta-anomer. (324 aa)
AJE40573.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (913 aa)
AJE40644.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (222 aa)
AJE40720.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
AJE40724.16-phospho-beta-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AJE40761.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AJE40847.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
AJE40986.1Mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
AJE41030.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
AJE41042.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (301 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
AJE41266.1ROK family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
AJE41420.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
AJE41600.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AJE41601.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJE41602.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
AJE41611.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJE41612.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJE41613.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AJE41699.1Aldose epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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