STRINGSTRING
hisF hisF AJE42422.1 AJE42422.1 AJE43594.1 AJE43594.1 AJE43093.1 AJE43093.1 AJE42780.1 AJE42780.1 AJE42709.1 AJE42709.1 hisE hisE hisG hisG egtD egtD egtC egtC egtB egtB AJE39279.1 AJE39279.1 AJE44515.1 AJE44515.1 AJE41339.1 AJE41339.1 pat pat AJE42196.1 AJE42196.1 hutH hutH AJE39885.1 AJE39885.1 AJE39939.1 AJE39939.1 AJE40088.1 AJE40088.1 AJE41320.1 AJE41320.1 AJE41179.1 AJE41179.1 hutU hutU AJE41021.1 AJE41021.1 hutI hutI AJE40667.1 AJE40667.1 AJE40452.1 AJE40452.1 hisD hisD hisC hisC hisB hisB hisH hisH priA-2 priA-2 hisI hisI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
AJE42422.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AJE43594.1Mobile element protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
AJE43093.1Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
AJE42780.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJE42709.1Cell division initiation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
hisEphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa)
egtDhistidyl-tRNA synthetase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (333 aa)
egtCHypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. (286 aa)
egtBSulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family. (438 aa)
AJE39279.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AJE44515.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AJE41339.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
AJE42196.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
hutHHistidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AJE39885.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE39939.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (465 aa)
AJE40088.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AJE41320.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
AJE41179.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (554 aa)
AJE41021.1N-formimino-L-glutamate deiminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
hutIImidazolonepropionase; Catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
AJE40667.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
AJE40452.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (447 aa)
hisCAspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa)
hisBImidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa)
priA-2Phosphoribosyl isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (243 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (141 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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