STRINGSTRING
AJE42561.1 AJE42561.1 ackA ackA AJE42581.1 AJE42581.1 AJE42650.1 AJE42650.1 AJE42669.1 AJE42669.1 AJE42716.1 AJE42716.1 AJE42755.1 AJE42755.1 AJE42780.1 AJE42780.1 AJE42924.1 AJE42924.1 AJE42928.1 AJE42928.1 AJE42967.1 AJE42967.1 AJE43098.1 AJE43098.1 AJE43155.1 AJE43155.1 AJE43170.1 AJE43170.1 AJE43276.1 AJE43276.1 AJE43432.1 AJE43432.1 fumC fumC AJE43465.1 AJE43465.1 AJE43523.1 AJE43523.1 AJE43841.1 AJE43841.1 AJE43928.1 AJE43928.1 AJE44002.1 AJE44002.1 AJE44090.1 AJE44090.1 AJE44113.1 AJE44113.1 AJE40370.1 AJE40370.1 AJE40366.1 AJE40366.1 AJE40220.1 AJE40220.1 AJE40178.1 AJE40178.1 AJE40106.1 AJE40106.1 AJE44146.1 AJE44146.1 AJE44259.1 AJE44259.1 AJE44307.1 AJE44307.1 AJE44308.1 AJE44308.1 AJE44371.1 AJE44371.1 AJE44449.1 AJE44449.1 AJE44493.1 AJE44493.1 AJE39939.1 AJE39939.1 AJE39748.1 AJE39748.1 AJE39678.1 AJE39678.1 AJE39505.1 AJE39505.1 AJE39405.1 AJE39405.1 AJE39383.1 AJE39383.1 AJE39344.1 AJE39344.1 AJE39274.1 AJE39274.1 AJE39045.1 AJE39045.1 AJE38984.1 AJE38984.1 AJE38923.1 AJE38923.1 AJE38892.1 AJE38892.1 AJE38832.1 AJE38832.1 AJE38696.1 AJE38696.1 AJE40429.1 AJE40429.1 AJE40430.1 AJE40430.1 AJE40531.1 AJE40531.1 AJE40573.1 AJE40573.1 leuA leuA AJE40922.1 AJE40922.1 AJE40980.1 AJE40980.1 AJE41005.1 AJE41005.1 AJE41035.1 AJE41035.1 AJE41042.1 AJE41042.1 ppc ppc AJE41420.1 AJE41420.1 AJE41436.1 AJE41436.1 AJE41460.1 AJE41460.1 AJE41493.1 AJE41493.1 AJE41593.1 AJE41593.1 AJE41600.1 AJE41600.1 AJE41601.1 AJE41601.1 AJE41602.1 AJE41602.1 AJE41611.1 AJE41611.1 AJE41612.1 AJE41612.1 AJE41613.1 AJE41613.1 AJE41745.1 AJE41745.1 AJE41746.1 AJE41746.1 acsA acsA AJE41788.1 AJE41788.1 AJE41950.1 AJE41950.1 AJE41951.1 AJE41951.1 mdh mdh AJE42196.1 AJE42196.1 pckG pckG aspA aspA AJE42298.1 AJE42298.1 AJE42314.1 AJE42314.1 AJE42458.1 AJE42458.1 AJE42473.1 AJE42473.1 AJE42579.1 AJE42579.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJE42561.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
AJE42581.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
AJE42650.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (313 aa)
AJE42669.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa)
AJE42716.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
AJE42755.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
AJE42780.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (481 aa)
AJE42924.1acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (935 aa)
AJE42928.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
AJE42967.1Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (327 aa)
AJE43098.1Glyoxalase/bleomycin resistance protein/dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AJE43155.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (580 aa)
AJE43170.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJE43276.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1124 aa)
AJE43432.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (472 aa)
AJE43465.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AJE43523.1Hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AJE43841.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AJE43928.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJE44002.1Malate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (530 aa)
AJE44090.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AJE44113.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
AJE40370.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (900 aa)
AJE40366.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
AJE40220.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
AJE40178.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
AJE40106.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AJE44146.1Peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (426 aa)
AJE44259.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (316 aa)
AJE44307.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
AJE44308.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AJE44371.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
AJE44449.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
AJE44493.1Transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
AJE39939.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (465 aa)
AJE39748.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AJE39678.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AJE39505.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
AJE39405.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AJE39383.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
AJE39344.1Hydrogenase maturation protein HypF; Derived by automated computational analysis using gene prediction method: Protein Homology. (795 aa)
AJE39274.1Nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
AJE39045.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
AJE38984.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
AJE38923.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AJE38892.1Peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
AJE38832.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
AJE38696.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AJE40429.1Peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (425 aa)
AJE40430.1Iron transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
AJE40531.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (915 aa)
AJE40573.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (913 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
AJE40922.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
AJE40980.1acetyl-CoA carboxyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AJE41005.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (119 aa)
AJE41035.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AJE41042.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LDH/MDH superfamily. (301 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
AJE41420.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
AJE41436.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
AJE41460.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
AJE41493.1Peroxidase; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (424 aa)
AJE41593.1Sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
AJE41600.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
AJE41601.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJE41602.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
AJE41611.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
AJE41612.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AJE41613.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AJE41745.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJE41746.1Beta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJE41788.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
AJE41950.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AJE41951.12-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (642 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AJE42196.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
AJE42298.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (563 aa)
AJE42314.1PEP-utilizing protein mobile subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
AJE42458.1Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
AJE42473.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
AJE42579.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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