STRINGSTRING
pfp pfp AJE42314.1 AJE42314.1 AJE42301.1 AJE42301.1 AJE42280.1 AJE42280.1 glyA glyA mdh mdh AJE42104.1 AJE42104.1 AJE41757.1 AJE41757.1 acsA acsA AJE41701.1 AJE41701.1 AJE41679.1 AJE41679.1 AJE41420.1 AJE41420.1 gpmA gpmA AJE41247.1 AJE41247.1 serC serC AJE41176.1 AJE41176.1 fbiC fbiC ppc ppc eno eno fbiB fbiB fbiA fbiA AJE40644.1 AJE40644.1 AJE42512.1 AJE42512.1 AJE40210.1 AJE40210.1 AJE40169.1 AJE40169.1 AJE40106.1 AJE40106.1 AJE40017.1 AJE40017.1 AJE39899.1 AJE39899.1 pfkA pfkA AJE39505.1 AJE39505.1 AJE39348.1 AJE39348.1 AJE39347.1 AJE39347.1 AJE39281.1 AJE39281.1 AJE39217.1 AJE39217.1 AJE39211.1 AJE39211.1 eno-2 eno-2 AJE39092.1 AJE39092.1 AJE38696.1 AJE38696.1 AJE38758.1 AJE38758.1 AJE44221.1 AJE44221.1 AJE44136.1 AJE44136.1 AJE44112.1 AJE44112.1 AJE43970.1 AJE43970.1 AJE43965.1 AJE43965.1 AJE43762.1 AJE43762.1 AJE43361.1 AJE43361.1 AJE43346.1 AJE43346.1 AJE43247.1 AJE43247.1 AJE43170.1 AJE43170.1 AJE42895.1 AJE42895.1 fbiD fbiD AJE42655.1 AJE42655.1 glyA-3 glyA-3 pfkA-2 pfkA-2 AJE42581.1 AJE42581.1 ackA ackA glyA-2 glyA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa)
AJE42314.1PEP-utilizing protein mobile subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (585 aa)
AJE42301.1Fructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
AJE42280.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (482 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
AJE42104.1Von Willebrand factor A; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
AJE41757.1Inhibition of morphological differentiation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
AJE41701.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (343 aa)
AJE41679.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (755 aa)
AJE41420.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa)
AJE41247.1RpiR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
serCPhosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
AJE41176.1Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
fbiCFO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (862 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (910 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa)
fbiBF420-0--gamma-glutamyl ligase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. (426 aa)
fbiA2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (319 aa)
AJE40644.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (222 aa)
AJE42512.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (527 aa)
AJE40210.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (759 aa)
AJE40169.1Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (355 aa)
AJE40106.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
AJE40017.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AJE39899.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE39505.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
AJE39348.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AJE39347.1Protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
AJE39281.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1081 aa)
AJE39217.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AJE39211.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
eno-2Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (423 aa)
AJE39092.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
AJE38696.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
AJE38758.1Aldehyde-activating protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AJE44221.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
AJE44136.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
AJE44112.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
AJE43970.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
AJE43965.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
AJE43762.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AJE43361.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
AJE43346.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AJE43247.1Deoxyribose-phosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
AJE43170.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
AJE42895.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (230 aa)
fbiD2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (215 aa)
AJE42655.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa)
AJE42581.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
Your Current Organism:
Streptomyces nodosus
NCBI taxonomy Id: 40318
Other names: ATCC 14899, ATCC 23942, BCRC 13768, CBS 926.68, CCRC 13768, CCRC:13768, DSM 40109, IFO 12895, ISP 5109, JCM 4297, JCM 4656, KCTC 9035, LMG 19340, LMG:19340, NBRC 12895, NCIMB 12816, NRRL B-2371, NRRL-ISP 5109, RIA 831, S. nodosus
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