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| | Pmob_0026 | KEGG: fno:Fnod_1542 dihydrofolate reductase region. (176 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (196 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (507 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) |
| | Pmob_0204 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: fno:Fnod_0042 CMP/dCMP deaminase zinc-binding. (169 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | Pmob_0219 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: tme:Tmel_1243 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa) |
| | Pmob_0241 | KEGG: tte:TTE0450 Glutamate formiminotransferase; TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase domain protein. (299 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (116 aa) |
| | Pmob_0254 | TIGRFAM: chorismate mutase; KEGG: ter:Tery_2493 chorismate mutase. (118 aa) |
| | Pmob_0275 | TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: pdi:BDI_2252 delta-1-pyrroline-5-carboxylate dehydrogenase. (543 aa) |
| | Pmob_0304 | PFAM: purine or other phosphorylase family 1; KEGG: sth:STH2155 uridine phosphorylase. (262 aa) |
| | Pmob_0313 | PFAM: aminotransferase class I and II; KEGG: tme:Tmel_1242 aminotransferase, class I and II. (401 aa) |
| | Pmob_0318 | PFAM: methylenetetrahydrofolate reductase; KEGG: fno:Fnod_1279 methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. (315 aa) |
| | Pmob_0440 | PFAM: GCN5-related N-acetyltransferase; KEGG: dsy:DSY1415 hypothetical protein. (140 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | Pmob_0573 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa) |
| | Pmob_0600 | PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: ctc:CTC01991 CLV1 receptor kinase; Belongs to the 5'-nucleotidase family. (630 aa) |
| | mggB | 5'-Nucleotidase domain protein; Involved in the biosynthesis of the compatible solute mannosylglucosylglycerate through a phosphorylating pathway. Catalyzes the dephosphorylation of mannosylglucosyl-3-phosphoglycerate (MGPG) to mannosylglucosylglycerate (MGG). Can also dephosphorylate UDP-glucose, ADP-glucose, GDP-mannose, glucosyl-3-phosphoglycerate (GPG), mannosyl- 3-phosphoglycerate (MPG), ADP, GDP and UDP. (503 aa) |
| | Pmob_0649 | PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: mma:MM_2289 hypothetical protein. (217 aa) |
| | pyrD | Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (300 aa) |
| | pyrK | Oxidoreductase FAD/NAD(P)-binding domain protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: cac:CAC2652 orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (289 aa) |
| | Pmob_0660 | Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (398 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa) |
| | Pmob_0734 | KEGG: tte:TTE2151 O-acetylhomoserine (thiol)-lyase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase. (429 aa) |
| | Pmob_0839 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; KEGG: tme:Tmel_0825 dihydrolipoamide dehydrogenase. (451 aa) |
| | Pmob_0877 | KEGG: tme:Tmel_1840 pyrimidine-nucleoside phosphorylase; TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase family 3; Pyrimidine nucleoside phosphorylase domain. (441 aa) |
| | Pmob_0926 | Gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; KEGG: amt:Amet_0676 gamma-glutamyltransferase. (534 aa) |
| | Pmob_0977 | KEGG: tme:Tmel_1193 aspartate carbamoyltransferase; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate transcarbamylase regulatory subunit; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain. (525 aa) |
| | Pmob_1015 | KEGG: tko:TK0242 ATP phosphoribosyltransferase, predicted regulatory subunit. (261 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa) |
| | Pmob_1018 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pfu:PF1660 imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (178 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa) |
| | hisA | PFAM: histidine biosynthesis protein; KEGG: pfu:PF1662 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (234 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tko:TK0249 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (218 aa) |
| | Pmob_1023 | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: pfu:PF1665 histidinol-phosphate aminotransferase. (368 aa) |
| | Pmob_1031 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: ctc:CTC02303 formiminotetrahydrofolate cyclodeaminase. (205 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (173 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (232 aa) |
| | Pmob_1103 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: tme:Tmel_1892 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (407 aa) |
| | Pmob_1152 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa) |
| | Pmob_1153 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: ctc:CTC02355 homoserine dehydrogenase. (431 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (141 aa) |
| | aroK | Shikimate kinase., 3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (495 aa) |
| | Pmob_1200 | PFAM: chorismate synthase; KEGG: tma:TM0347 chorismate synthase. (368 aa) |
| | Pmob_1201 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: tma:TM0346 shikimate 5-dehydrogenase. (261 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | Pmob_1203 | PFAM: Prephenate dehydrogenase; KEGG: cff:CFF8240_1500 prephenate dehydrogenase. (280 aa) |
| | Pmob_1204 | KEGG: cth:Cthe_0880 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (339 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: chy:CHY_1583 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: drm:Dred_0251 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (253 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa) |
| | Pmob_1212 | TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. (196 aa) |
| | Pmob_1213 | PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: aae:aq_582 anthranilate synthase component I. (492 aa) |
| | Pmob_1219 | Amidohydrolase; KEGG: tpt:Tpet_1276 amidohydrolase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein. (369 aa) |
| | Pmob_1220 | PFAM: aminotransferase class-III; KEGG: tme:Tmel_1879 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (379 aa) |
| | Pmob_1221 | KEGG: tpt:Tpet_1274 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (399 aa) |
| | dapH | Tetrahydrodipicolinate succinyltransferase domain protein; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (233 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (212 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa) |
| | Pmob_1225 | PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: dsy:DSY4977 hypothetical protein. (413 aa) |
| | Pmob_1226 | KEGG: tpt:Tpet_1269 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (323 aa) |
| | thyX | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (261 aa) |
| | Pmob_1235 | Hypothetical protein; KEGG: gfo:GFO_1492 3-dehydroquinate synthase. (329 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (420 aa) |
| | Pmob_1367 | Glutamate formimidoyltransferase; PFAM: Formiminotransferase domain protein; KEGG: tma:TM0843 formiminotransferase- cyclodeaminase/formiminotetrahydrofolate cyclodeaminase, putative. (305 aa) |
| | Pmob_1370 | KEGG: tma:TM0206 hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (170 aa) |
| | Pmob_1371 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (275 aa) |
| | Pmob_1435 | PFAM: phosphoribulokinase/uridine kinase; KEGG: fno:Fnod_0134 phosphoribulokinase/uridine kinase. (553 aa) |
| | Pmob_1456 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; KEGG: tpt:Tpet_0759 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (438 aa) |
| | Pmob_1467 | KEGG: tma:TM0172 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; S-adenosyl-L-homocysteine hydrolase, NAD binding. (408 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | Pmob_1480 | TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: tma:TM0665 cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (296 aa) |
| | Pmob_1481 | KEGG: tpt:Tpet_0265 serine O-acetyltransferase. (203 aa) |
| | Pmob_1500 | PFAM: thymidine kinase; KEGG: tpt:Tpet_0519 thymidine kinase. (196 aa) |
| | Pmob_1555 | PFAM: macrophage migration inhibitory factor family protein; KEGG: mca:MCA2795 phenylpyruvate tautomerase, putative. (112 aa) |
| | Pmob_1573 | TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; KEGG: tko:TK0504 aspartate racemase. (236 aa) |
| | Pmob_1574 | PFAM: transglutaminase domain protein; KEGG: efa:EF1512 hypothetical protein. (453 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa) |
| | Pmob_1583 | PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: tpt:Tpet_1731 Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (431 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase. (311 aa) |
| | Pmob_1660 | Phosphoribosylaminoimidazolecarboxamide formyltransferase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region; KEGG: tme:Tmel_1545 IMP cyclohydrolase. (489 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: tte:TTE2495 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: tte:TTE0815 Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (347 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; argininosuccinate synthase; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: tte:TTE0816 Carbamoylphosphate synthase large subunit (split gene in MJ); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (1496 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: tte:TTE2493 argininosuccinate lyase. (441 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (388 aa) |
| | Pmob_1726 | TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: bvu:BVU_2531 putative purine permease. (452 aa) |
| | Pmob_1730 | KEGG: ctc:CTC01781 dihydropyrimidinase; TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase. (451 aa) |
| | Pmob_1743 | TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: cdf:CD3179 putative dihydroorotate dehydrogenase, catalytic subunit. (363 aa) |
| | ade | KEGG: amt:Amet_4567 adenine deaminase; TIGRFAM: adenine deaminase; PFAM: amidohydrolase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (570 aa) |
| | fhs | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tme:Tmel_0304 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (554 aa) |
| | folD | Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (273 aa) |
| | Pmob_1758 | PFAM: aminotransferase class I and II; KEGG: ctc:CTC00825 putative aspartate aminotransferase. (390 aa) |
| | Pmob_1759 | KEGG: cno:NT01CX_1254 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain. (291 aa) |
| | Pmob_1760 | KEGG: cbe:Cbei_4499 L-serine dehydratase, iron-sulfur-dependent, beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain. (229 aa) |
| | purD | KEGG: cpr:CPR_0676 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. (412 aa) |
| | purH | KEGG: ctc:CTC01962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. (508 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sat:SYN_00889 phosphoribosylformylglycinamidine cyclo-ligase. (322 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | Pmob_1791 | KEGG: tme:Tmel_0730 vitamin B12 dependent methionine synthase, activation region. (173 aa) |
| | Pmob_1792 | PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tme:Tmel_0729 homocysteine S-methyltransferase. (774 aa) |
| | Pmob_1793 | KEGG: tma:TM0943 glutamine synthetase; TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp. (441 aa) |
| | Pmob_1794 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: drm:Dred_2805 glutamate synthase (ferredoxin). (1526 aa) |
| | Pmob_1795 | TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD dependent oxidoreductase; KEGG: pth:PTH_0735 NADPH-dependent glutamate synthase beta chain and related oxidoreductases. (506 aa) |
| | Pmob_1798 | PFAM: inositol monophosphatase; KEGG: tme:Tmel_1174 inositol-phosphate phosphatase. (258 aa) |
| | Pmob_1813 | Glutamate dehydrogenase (NADP(+)); PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: pth:PTH_0050 glutamate dehydrogenase/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (454 aa) |
| | Pmob_1817 | PFAM: aminotransferase class I and II; KEGG: tpt:Tpet_1516 aminotransferase, class I and II. (385 aa) |
| | Pmob_1828 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa) |
| | cysS | KEGG: tme:Tmel_0064 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (469 aa) |
| | Pmob_1900 | TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: rpe:RPE_2602 glutamate synthase (NADPH), homotetrameric. (747 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (483 aa) |
| | Pmob_1909 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (207 aa) |
| | gcvT | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (441 aa) |
| | gcvPA | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa) |
| | gcvPB | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (478 aa) |
| | Pmob_1955 | PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: ppe:PEPE_1467 phosphoribosylcarboxyaminoimidazole (NCAIR) mutase. (139 aa) |
| | purC | KEGG: tte:TTE0588 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (238 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (90 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (227 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (727 aa) |
| | Pmob_1960 | PFAM: glutamine amidotransferase class-II; KEGG: tte:TTE0812 Glutamine phosphoribosylpyrophosphate amidotransferase. (158 aa) |
