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Pmob_0254 Pmob_0254 Pmob_0313 Pmob_0313 Pmob_0318 Pmob_0318 Pmob_0440 Pmob_0440 lysA lysA Pmob_0649 Pmob_0649 metAA metAA Pmob_0734 Pmob_0734 Pmob_1015 Pmob_1015 hisG hisG hisD hisD Pmob_1018 Pmob_1018 hisH hisH hisA hisA hisF hisF hisI hisI Pmob_1023 Pmob_1023 Pmob_1103 Pmob_1103 Pmob_1152 Pmob_1152 Pmob_1153 Pmob_1153 aroQ aroQ aroK aroK Pmob_1200 Pmob_1200 Pmob_1201 Pmob_1201 aroA aroA Pmob_1203 Pmob_1203 Pmob_1204 Pmob_1204 trpA trpA trpB trpB trpF trpF trpC trpC trpD trpD Pmob_1212 Pmob_1212 Pmob_1213 Pmob_1213 Pmob_1219 Pmob_1219 Pmob_1220 Pmob_1220 Pmob_1221 Pmob_1221 dapH dapH dapB dapB dapA dapA Pmob_1225 Pmob_1225 Pmob_1226 Pmob_1226 Pmob_1235 Pmob_1235 Pmob_1467 Pmob_1467 Pmob_1480 Pmob_1480 Pmob_1481 Pmob_1481 Pmob_1555 Pmob_1555 Pmob_1573 Pmob_1573 Pmob_1574 Pmob_1574 thrB thrB pheA pheA argJ argJ argB argB argD argD argH argH argC argC Pmob_1758 Pmob_1758 Pmob_1759 Pmob_1759 Pmob_1760 Pmob_1760 Pmob_1791 Pmob_1791 Pmob_1792 Pmob_1792 Pmob_1798 Pmob_1798 Pmob_1817 Pmob_1817 cysS cysS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pmob_0254TIGRFAM: chorismate mutase; KEGG: ter:Tery_2493 chorismate mutase. (118 aa)
Pmob_0313PFAM: aminotransferase class I and II; KEGG: tme:Tmel_1242 aminotransferase, class I and II. (401 aa)
Pmob_0318PFAM: methylenetetrahydrofolate reductase; KEGG: fno:Fnod_1279 methylenetetrahydrofolate reductase (NAD(P)H); Belongs to the methylenetetrahydrofolate reductase family. (315 aa)
Pmob_0440PFAM: GCN5-related N-acetyltransferase; KEGG: dsy:DSY1415 hypothetical protein. (140 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
Pmob_0649PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: mma:MM_2289 hypothetical protein. (217 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (309 aa)
Pmob_0734KEGG: tte:TTE2151 O-acetylhomoserine (thiol)-lyase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase. (429 aa)
Pmob_1015KEGG: tko:TK0242 ATP phosphoribosyltransferase, predicted regulatory subunit. (261 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
Pmob_1018PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: pfu:PF1660 imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (178 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)
hisAPFAM: histidine biosynthesis protein; KEGG: pfu:PF1662 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (234 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisITIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tko:TK0249 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. (218 aa)
Pmob_1023TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: pfu:PF1665 histidinol-phosphate aminotransferase. (368 aa)
Pmob_1103TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: tme:Tmel_1892 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (407 aa)
Pmob_1152Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa)
Pmob_1153PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: ctc:CTC02355 homoserine dehydrogenase. (431 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (141 aa)
aroKShikimate kinase., 3-dehydroquinate synthase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (495 aa)
Pmob_1200PFAM: chorismate synthase; KEGG: tma:TM0347 chorismate synthase. (368 aa)
Pmob_1201PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: tma:TM0346 shikimate 5-dehydrogenase. (261 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa)
Pmob_1203PFAM: Prephenate dehydrogenase; KEGG: cff:CFF8240_1500 prephenate dehydrogenase. (280 aa)
Pmob_1204KEGG: cth:Cthe_0880 phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (339 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (258 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: chy:CHY_1583 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (207 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: drm:Dred_0251 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (253 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (344 aa)
Pmob_1212TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: cth:Cthe_0874 glutamine amidotransferase of anthranilate synthase. (196 aa)
Pmob_1213PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: aae:aq_582 anthranilate synthase component I. (492 aa)
Pmob_1219Amidohydrolase; KEGG: tpt:Tpet_1276 amidohydrolase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein. (369 aa)
Pmob_1220PFAM: aminotransferase class-III; KEGG: tme:Tmel_1879 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (379 aa)
Pmob_1221KEGG: tpt:Tpet_1274 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; Belongs to the aspartokinase family. (399 aa)
dapHTetrahydrodipicolinate succinyltransferase domain protein; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (233 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (212 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
Pmob_1225PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: dsy:DSY4977 hypothetical protein. (413 aa)
Pmob_1226KEGG: tpt:Tpet_1269 aspartate-semialdehyde dehydrogenase; TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (323 aa)
Pmob_1235Hypothetical protein; KEGG: gfo:GFO_1492 3-dehydroquinate synthase. (329 aa)
Pmob_1467KEGG: tma:TM0172 adenosylhomocysteinase; TIGRFAM: adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; S-adenosyl-L-homocysteine hydrolase, NAD binding. (408 aa)
Pmob_1480TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: tma:TM0665 cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (296 aa)
Pmob_1481KEGG: tpt:Tpet_0265 serine O-acetyltransferase. (203 aa)
Pmob_1555PFAM: macrophage migration inhibitory factor family protein; KEGG: mca:MCA2795 phenylpyruvate tautomerase, putative. (112 aa)
Pmob_1573TIGRFAM: aspartate racemase; PFAM: Asp/Glu/hydantoin racemase; KEGG: tko:TK0504 aspartate racemase. (236 aa)
Pmob_1574PFAM: transglutaminase domain protein; KEGG: efa:EF1512 hypothetical protein. (453 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (307 aa)
pheAPFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase. (311 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: tte:TTE2495 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: tte:TTE2493 argininosuccinate lyase. (441 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa)
Pmob_1758PFAM: aminotransferase class I and II; KEGG: ctc:CTC00825 putative aspartate aminotransferase. (390 aa)
Pmob_1759KEGG: cno:NT01CX_1254 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain. (291 aa)
Pmob_1760KEGG: cbe:Cbei_4499 L-serine dehydratase, iron-sulfur-dependent, beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain. (229 aa)
Pmob_1791KEGG: tme:Tmel_0730 vitamin B12 dependent methionine synthase, activation region. (173 aa)
Pmob_1792PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tme:Tmel_0729 homocysteine S-methyltransferase. (774 aa)
Pmob_1798PFAM: inositol monophosphatase; KEGG: tme:Tmel_1174 inositol-phosphate phosphatase. (258 aa)
Pmob_1817PFAM: aminotransferase class I and II; KEGG: tpt:Tpet_1516 aminotransferase, class I and II. (385 aa)
cysSKEGG: tme:Tmel_0064 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (469 aa)
Your Current Organism:
Petrotoga mobilis
NCBI taxonomy Id: 403833
Other names: P. mobilis SJ95, Petrotoga mobilis DSM 10674, Petrotoga mobilis SJ95, Petrotoga mobilis str. SJ95, Petrotoga mobilis strain SJ95
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