STRINGSTRING
gdhA gdhA por-1 por-1 Gbem_0226 Gbem_0226 sucD-1 sucD-1 sucC-1 sucC-1 pyc pyc gcvT gcvT gcvH gcvH gcvP1 gcvP1 gcvP2 gcvP2 lplA lplA lipA lipA bkdA bkdA bkdB bkdB bkdF bkdF ilvE ilvE lpdA-3 lpdA-3 ppdK ppdK sucA sucA sucB sucB lpdA-1 lpdA-1 lipB lipB pckA-2 pckA-2 pckA pckA fumB fumB leuB leuB pyk pyk cimA cimA gabD gabD acnB acnB maeB-1 maeB-1 oadA oadA maeB-2 maeB-2 sucC-2 sucC-2 sucD-2 sucD-2 larG larG gltA-1 gltA-1 maeB-3 maeB-3 nifV nifV acnA acnA aceF aceF pdhB pdhB pdhA pdhA Gbem_2258 Gbem_2258 leuD leuD leuC leuC leuA leuA ilvN ilvN ilvB ilvB ilvD ilvD ilvC ilvC Gbem_2777 Gbem_2777 aspA aspA gltB gltB gltD gltD korC korC korB korB korA korA korD korD mdh mdh icd icd glnA-1 glnA-1 glnA-2 glnA-2 vorC vorC vorB vorB vorA vorA vorD vorD sucD-3 sucD-3 sucC-3 sucC-3 frdB frdB frdA frdA frdC frdC Gbem_3555 Gbem_3555 Gbem_3597 Gbem_3597 lpdA-2 lpdA-2 gltA-2 gltA-2 por-2 por-2 Gbem_4036 Gbem_4036
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gdhAGlutamate dehydrogenase, NADP-dependent; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
por-1Pyruvate:ferredoxin/flavodoxin oxidoreductase. (1183 aa)
Gbem_0226Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (911 aa)
sucD-1succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (298 aa)
sucC-1succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
pycPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa)
gcvTGlycine cleavage system T protein. (363 aa)
gcvHGlycine cleavage system lipoyl carrier protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
gcvP1Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (445 aa)
gcvP2Glycine cleavage system P protein, subunit 2. (479 aa)
lplALipoate--protein ligase A. (266 aa)
lipALipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)
bkdABranched-chain 2-oxoacid dehydrogenase complex, E1 protein, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (351 aa)
bkdBBranched-chain 2-oxoacid dehydrogenase complex, E1 protein, beta subunit, putative. (320 aa)
bkdFDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Branched-chain 2-oxoacid dehydrogenase complex, E2 protein, dihydrolipoamide acyltransferase, putative. (406 aa)
ilvEBranched-chain amino acid aminotransferase. (356 aa)
lpdA-3Dihydrolipoamide dehydrogenase. (468 aa)
ppdKPyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (914 aa)
sucA2-oxoglutarate dehydrogenase, E1 protein. (897 aa)
sucB2-oxoglutarate dehydrogenase, E2 protein, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
lpdA-1Dihydrolipoamide dehydrogenase. (470 aa)
lipBOctanoyl-(acyl carrier protein)--protein octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (204 aa)
pckA-2Phosphoenolpyruvate carboxykinase, ATP-dependent; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
pckAPhosphoenolpyruvate carboxykinase, GTP-dependent; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (647 aa)
fumBFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (541 aa)
leuB3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (481 aa)
cimACitramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
gabD4-oxobutanoate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
acnBAconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (839 aa)
maeB-1Malate oxidoreductase, NADP-dependent, phosphate acetyltransferase-like domain-containing. (749 aa)
oadAOxaloacetate decarboxylase. (690 aa)
maeB-2Malate oxidoreductase, NADP-dependent, phosphate acetyltransferase-like domain-containing. (779 aa)
sucC-2succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
sucD-2succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (308 aa)
larGLipoyl carrier protein LarG; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gltA-1Citrate synthase; Belongs to the citrate synthase family. (441 aa)
maeB-3Malate oxidoreductase, NADP-dependent, phosphate acetyltransferase-like domain-containing. (749 aa)
nifVHomocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (382 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa)
aceFPyruvate dehydrogenase complex, E2 protein, dihydrolipoamide acetyltransferase. (480 aa)
pdhBPyruvate dehydrogenase complex, E1 protein, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
pdhAPyruvate dehydrogenase complex, E1 protein, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
Gbem_2258Aconitate hydratase, putative. (648 aa)
leuDIsopropylmalate/citramalate isomerase, small subunit; Belongs to the LeuD family. (175 aa)
leuCIsopropylmalate/citramalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
ilvNAcetolactate synthase, small subunit. (163 aa)
ilvBAcetolactate synthase, large subunit, biosynthetic type. (566 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa)
ilvCKetol-acid reductoisomerase, class II; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa)
Gbem_2777Glu/Leu/Phe/Val dehydrogenase superfamily protein. (986 aa)
aspAAspartate ammonia-lyase. (466 aa)
gltBNADPH-dependent glutamate synthase, glutamine amidotransferase and FMN-binding subunit. (1527 aa)
gltDNADPH-dependent glutamate synthase, NADPH oxidoreductase subunit. (493 aa)
korC2-oxoglutarate:ferredoxin oxidoreductase, gamma subunit. (182 aa)
korB2-oxoglutarate:ferredoxin oxidoreductase, thiamin diphosphate-binding subunit. (270 aa)
korA2-oxoglutarate:ferredoxin oxidoreductase, alpha subunit. (377 aa)
korD2-oxoglutarate:ferredoxin oxidoreductase, ferredoxin subunit. (64 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)
icdIsocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (743 aa)
glnA-1Glutamine synthetase, type I. (470 aa)
glnA-2Glutamine synthetase, type III. (695 aa)
vorC2-oxoacid:ferredoxin oxidoreductase, gamma subunit. (183 aa)
vorB2-oxoacid:ferredoxin oxidoreductase, thiamin diphosphate-binding subunit. (246 aa)
vorA2-oxoacid:ferredoxin oxidoreductase, alpha subunit. (368 aa)
vorD2-oxoacid:ferredoxin oxidoreductase, ferredoxin subunit. (67 aa)
sucD-3succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucC-3succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
frdBSuccinate dehydrogenase/fumarate reductase, iron-sulfur protein. (246 aa)
frdASuccinate dehydrogenase/fumarate reductase, flavoprotein subunit. (637 aa)
frdCSuccinate dehydrogenase/fumarate reductase, cytochrome b558 subunit. (221 aa)
Gbem_3555Cyclase/hydrolase, putative. (226 aa)
Gbem_3597Flavocytochrome c; 4 heme-binding sites; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (591 aa)
lpdA-2Dihydrolipoamide dehydrogenase, putative. (449 aa)
gltA-2Citrate synthase; Belongs to the citrate synthase family. (454 aa)
por-2Pyruvate:ferredoxin/flavodoxin oxidoreductase. (1238 aa)
Gbem_4036Flavocytochrome c; 4 heme-binding sites; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (598 aa)
Your Current Organism:
Geobacter bemidjiensis
NCBI taxonomy Id: 404380
Other names: G. bemidjiensis Bem, Geobacter bemidjiensis Bem, Geobacter bemidjiensis str. Bem, Geobacter bemidjiensis strain Bem
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.