(46 nodes) Sulfur metabolism, and Cysteine and methionine metabolism network (Geobacter bemidjiensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	Gbem_0056	Pyridoxal-5'-phosphate-dependent enzyme. (385 aa)
	Gbem_0089	Rhodanese homology domain pair protein. (324 aa)
	Gbem_0161	Ferredoxin, Rieske superfamily. (100 aa)
	Gbem_0271	Nitrite/sulfite reductase domain protein. (426 aa)
	metH	5-methyltetrahydrofolate--homocysteine S-methyltransferase, cobalamin-dependent. (811 aa)
	metX	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (367 aa)
	iscR	Helix-turn-helix iron-sulfur cluster-binding transcriptional regulator IscR. (152 aa)
	metF-2	Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase. (610 aa)
	Gbem_0614	Sulfite reductase, assimilatory; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (234 aa)
	Gbem_0735	Rubredoxin. (52 aa)
	metY-1	O-acetyl-L-homoserine sulfhydrylase. (427 aa)
	Gbem_1145	Membrane protein, major facilitator superfamily. (434 aa)
	Gbem_1268	Winged helix-turn-helix transcriptional regulator, Rrf2 family. (137 aa)
	metK-1	ATP--methionine S-adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa)
	ahcY	S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (465 aa)
	nifU	Nitrogen fixation iron-sulfur cluster assembly protein NifU; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (284 aa)
	nifS	Nitrogen fixation iron-sulfur cluster assembly cysteine desulfurase NifS; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. (389 aa)
	Gbem_1583	Acetylene hydratase-related molybdopterin oxidoreductase and desulfurase, putative; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1139 aa)
	cysN-2	Sulfate adenylyltransferase, subunit 1. (408 aa)
	cysD-2	Sulfate adenylyltransferase, subunit 2. (268 aa)
	cysE-1	Serine O-acetyltransferase. (222 aa)
	cysP	Sulfate ABC transporter, periplasmic sulfate-binding protein. (329 aa)
	Gbem_1724	Protein of unknown function DUF2292. (51 aa)
	metK-3	ATP--methionine S-adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
	cysU	Sulfate ABC transporter, membrane protein CysU; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (276 aa)
	cysW	Sulfate ABC transporter, membrane protein CysW. (293 aa)
	cysA	Sulfate ABC transporter, ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (355 aa)
	cysE-2	Serine O-acetyltransferase. (175 aa)
	Gbem_1978	Sulfite reductase subunit, putative. (314 aa)
	metY-3	O-acetyl-L-homoserine sulfhydrylase. (417 aa)
	cysK	Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (317 aa)
	metC-1	Cystathionine gamma-synthase/beta-lyase. (382 aa)
	metC-2	Cystathionine gamma-synthase/beta-lyase. (377 aa)
	Gbem_2220	Hypothetical protein. (441 aa)
	cysN-1	Sulfate adenylyltransferase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (551 aa)
	cysD-1	Sulfate adenylyltransferase, subunit 2. (301 aa)
	apr	Adenosine-5'-phosphosulfate reductase, glutathione-dependent; Reduction of activated sulfate into sulfite. (230 aa)
	Gbem_2484	Winged helix-turn-helix transcriptional regulator, Rrf2 family. (153 aa)
	Gbem_2796	thioredoxin/NifU-like domain protein. (73 aa)
	Gbem_3061	Winged helix-turn-helix transcriptional regulator, Rrf2 family. (162 aa)
	cysM	Cysteine synthase B. (360 aa)
	Gbem_3229	Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase. (661 aa)
	metK-2	ATP--methionine S-adenosyltransferase. (401 aa)
	metY-2	O-acetyl-L-homoserine sulfhydrylase. (427 aa)
	metF-1	5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (291 aa)
	cysS	cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (480 aa)

Your Current Organism:

Geobacter bemidjiensis

NCBI taxonomy Id: 404380
Other names: G. bemidjiensis Bem, Geobacter bemidjiensis Bem, Geobacter bemidjiensis str. Bem, Geobacter bemidjiensis strain Bem

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Gbem_0056	Gbem_0089	Gbem_0056	Gbem_0089	Pyridoxal-5'-phosphate-dependent enzyme.	Rhodanese homology domain pair protein.	0.900
Gbem_0056	ahcY	Gbem_0056	Gbem_1346	Pyridoxal-5'-phosphate-dependent enzyme.	S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.900
Gbem_0056	cysK	Gbem_0056	Gbem_1983	Pyridoxal-5'-phosphate-dependent enzyme.	Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.924
Gbem_0056	metC-1	Gbem_0056	Gbem_2218	Pyridoxal-5'-phosphate-dependent enzyme.	Cystathionine gamma-synthase/beta-lyase.	0.949
Gbem_0056	metC-2	Gbem_0056	Gbem_2219	Pyridoxal-5'-phosphate-dependent enzyme.	Cystathionine gamma-synthase/beta-lyase.	0.948
Gbem_0056	metF-2	Gbem_0056	Gbem_0613	Pyridoxal-5'-phosphate-dependent enzyme.	Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase.	0.921
Gbem_0056	metH	Gbem_0056	Gbem_0277	Pyridoxal-5'-phosphate-dependent enzyme.	5-methyltetrahydrofolate--homocysteine S-methyltransferase, cobalamin-dependent.	0.919
Gbem_0056	metY-1	Gbem_0056	Gbem_1015	Pyridoxal-5'-phosphate-dependent enzyme.	O-acetyl-L-homoserine sulfhydrylase.	0.916
Gbem_0056	metY-2	Gbem_0056	Gbem_3288	Pyridoxal-5'-phosphate-dependent enzyme.	O-acetyl-L-homoserine sulfhydrylase.	0.916
Gbem_0056	metY-3	Gbem_0056	Gbem_1982	Pyridoxal-5'-phosphate-dependent enzyme.	O-acetyl-L-homoserine sulfhydrylase.	0.916
Gbem_0089	Gbem_0056	Gbem_0089	Gbem_0056	Rhodanese homology domain pair protein.	Pyridoxal-5'-phosphate-dependent enzyme.	0.900
Gbem_0089	Gbem_0271	Gbem_0089	Gbem_0271	Rhodanese homology domain pair protein.	Nitrite/sulfite reductase domain protein.	0.921
Gbem_0089	Gbem_1978	Gbem_0089	Gbem_1978	Rhodanese homology domain pair protein.	Sulfite reductase subunit, putative.	0.902
Gbem_0089	apr	Gbem_0089	Gbem_2354	Rhodanese homology domain pair protein.	Adenosine-5'-phosphosulfate reductase, glutathione-dependent; Reduction of activated sulfate into sulfite.	0.918
Gbem_0089	cysK	Gbem_0089	Gbem_1983	Rhodanese homology domain pair protein.	Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.838
Gbem_0089	metC-1	Gbem_0089	Gbem_2218	Rhodanese homology domain pair protein.	Cystathionine gamma-synthase/beta-lyase.	0.838
Gbem_0089	metC-2	Gbem_0089	Gbem_2219	Rhodanese homology domain pair protein.	Cystathionine gamma-synthase/beta-lyase.	0.919
Gbem_0089	nifS	Gbem_0089	Gbem_1569	Rhodanese homology domain pair protein.	Nitrogen fixation iron-sulfur cluster assembly cysteine desulfurase NifS; Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine.	0.921
Gbem_0161	Gbem_0614	Gbem_0161	Gbem_0614	Ferredoxin, Rieske superfamily.	Sulfite reductase, assimilatory; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.	0.976
Gbem_0161	Gbem_1145	Gbem_0161	Gbem_1145	Ferredoxin, Rieske superfamily.	Membrane protein, major facilitator superfamily.	0.485