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| | nfnA | NADH-dependent ferredoxin:NADP+ oxidoreductase, alpha subunit. (469 aa) |
| | Gbem_0056 | Pyridoxal-5'-phosphate-dependent enzyme. (385 aa) |
| | aroK-2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (174 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa) |
| | pyc | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa) |
| | metH | 5-methyltetrahydrofolate--homocysteine S-methyltransferase, cobalamin-dependent. (811 aa) |
| | tklA | Transketolase, A protein. (274 aa) |
| | tklB | Transketolase, B protein. (310 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (367 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | hisZ | Regulatory subunit of short ATP phosphoribosyltransferase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (440 aa) |
| | ilvE | Branched-chain amino acid aminotransferase. (356 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa) |
| | metF-2 | Methionine synthase / methylenetetrahydrofolate reductase(NADPH); 5-methyltetrahydrofolate--homocysteine S-methyltransferase and 5,10-methylenetetrahydrofolate reductase. (610 aa) |
| | Gbem_0627 | Amino acid aminotransferase, putative. (434 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa) |
| | hisGL | ATP phosphoribosyltransferase, long form; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (290 aa) |
| | aroC-2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (360 aa) |
| | Gbem_0877 | Nucleoside phosphorylase. (255 aa) |
| | leuB | 3-isopropylmalate/3-methylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa) |
| | asd-2 | Aspartate-4-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (365 aa) |
| | asd-1 | Aspartate-4-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | argC | N-acetyl-glutamyl-5-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | Gbem_1007 | Ketose-1,6-bisphosphate aldolase, class II, putative. (427 aa) |
| | asnB-3 | Asparagine synthetase. (660 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | Gbem_1264 | Aspartate 4-kinase; Belongs to the aspartokinase family. (404 aa) |
| | cimA | Citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa) |
| | acnB | Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (839 aa) |
| | thrC | Threonine synthase. (458 aa) |
| | metK-1 | ATP--methionine S-adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (389 aa) |
| | tkt | Transketolase; Belongs to the transketolase family. (711 aa) |
| | tal-2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (374 aa) |
| | argJ | Ornithine:glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (391 aa) |
| | aroC-1 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (393 aa) |
| | aroK-1 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa) |
| | aroB-1 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (362 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | asnB-4 | Asparagine synthetase. (620 aa) |
| | cysE-1 | Serine O-acetyltransferase. (222 aa) |
| | gltA-1 | Citrate synthase; Belongs to the citrate synthase family. (441 aa) |
| | metK-3 | ATP--methionine S-adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | asnB-5 | Asparagine synthetase. (629 aa) |
| | cysE-2 | Serine O-acetyltransferase. (175 aa) |
| | aroB-2 | 3-dehydroquinate synthase. (402 aa) |
| | Gbem_1875 | Chorismate mutase. (91 aa) |
| | Gbem_1879 | Phosphoglycerate mutase family protein. (399 aa) |
| | Gbem_1886 | Arginase; Belongs to the arginase family. (303 aa) |
| | ltaE | L-threonine aldolase, low-specificity; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (352 aa) |
| | trpG | Anthranilate synthase, glutamine amidotransferase subunit. (189 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (352 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (266 aa) |
| | trpB2 | Tryptophan synthase, homodimeric beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (451 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (206 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (532 aa) |
| | aroF | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | cysK | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (317 aa) |
| | acnA | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (934 aa) |
| | metC-1 | Cystathionine gamma-synthase/beta-lyase. (382 aa) |
| | metC-2 | Cystathionine gamma-synthase/beta-lyase. (377 aa) |
| | Gbem_2258 | Aconitate hydratase, putative. (648 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | trpE | Anthranilate synthase, catalytic subunit; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (491 aa) |
| | argA | N-acetylglutamate synthase; Belongs to the acetyltransferase family. (149 aa) |
| | pfk-2 | 6-phosphofructokinase, ATP-dependent; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa) |
| | aroH | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (450 aa) |
| | leuD | Isopropylmalate/citramalate isomerase, small subunit; Belongs to the LeuD family. (175 aa) |
| | leuC | Isopropylmalate/citramalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (427 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | ilvN | Acetolactate synthase, small subunit. (163 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type. (566 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (553 aa) |
| | ilvC | Ketol-acid reductoisomerase, class II; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (490 aa) |
| | prsA | Ribose-5-phosphate 1-pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | pfk-3 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (390 aa) |
| | tabA | Ornithine/diaminopimelate/arginine decarboxylase-related protein TabA. (421 aa) |
| | gltB | NADPH-dependent glutamate synthase, glutamine amidotransferase and FMN-binding subunit. (1527 aa) |
| | gltD | NADPH-dependent glutamate synthase, NADPH oxidoreductase subunit. (493 aa) |
| | icd | Isocitrate dehydrogenase, NADP-dependent; Belongs to the monomeric-type IDH family. (743 aa) |
| | Gbem_2918 | Carboxynorspermidine/carboxyspermidine dehydrogenase. (398 aa) |
| | pfk-1 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (359 aa) |
| | hom | Homoserine dehydrogenase. (436 aa) |
| | glnA-1 | Glutamine synthetase, type I. (470 aa) |
| | glnA-2 | Glutamine synthetase, type III. (695 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | rpiB | Ribose-5-phosphate isomerase B. (151 aa) |
| | cysM | Cysteine synthase B. (360 aa) |
| | argE | N-acetylornithine deacetylase, putative. (403 aa) |
| | pfk-4 | 6-phosphofructokinase, putative; Belongs to the carbohydrate kinase PfkB family. (311 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (429 aa) |
| | tyrA | Prephenate dehydrogenase. (286 aa) |
| | pheA | Chorismate mutase and prephenate dehydratase. (359 aa) |
| | metK-2 | ATP--methionine S-adenosyltransferase. (401 aa) |
| | Gbem_3287 | Amino acid aminotransferase, putative. (397 aa) |
| | trpB1 | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa) |
| | proC | Delta-1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | ltaA | L-allo-threonine aldolase, stereospecific. (339 aa) |
| | gpmA | Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (234 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | aroG-2 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (341 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (397 aa) |
| | argF | Ornithine carbamyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (303 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (406 aa) |
| | argH | Argininosuccinate lyase. (458 aa) |
| | tdcB | Threonine and serine dehydratase and deaminase, catabolic. (402 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase. (109 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (243 aa) |
| | hisH | Imidazoleglycerol-phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa) |
| | hisGS | ATP phosphoribosyltransferase, short form; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (212 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa) |
| | proA | Glutamyl-5-phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (373 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (480 aa) |
| | gltA-2 | Citrate synthase; Belongs to the citrate synthase family. (454 aa) |
| | dapL | L,L-diaminopimelate aminotransferase; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (267 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (417 aa) |
