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CIRG_00912 CIRG_00912 CIRG_09984 CIRG_09984 CIRG_01440 CIRG_01440 CIRG_10199 CIRG_10199 CIRG_01714 CIRG_01714 CIRG_01754 CIRG_01754 CIRG_00730 CIRG_00730 CIRG_00860 CIRG_00860 CIRG_01239 CIRG_01239 CIRG_02523 CIRG_02523 CIRG_02627 CIRG_02627 CIRG_02229 CIRG_02229 CIRG_01550 CIRG_01550 CIRG_01163 CIRG_01163 CIRG_03559 CIRG_03559 CIRG_02187 CIRG_02187 CIRG_03777 CIRG_03777 CIRG_02416 CIRG_02416 CIRG_10196 CIRG_10196 CIRG_02414 CIRG_02414 CIRG_03091 CIRG_03091 CIRG_02805 CIRG_02805 CIRG_03776 CIRG_03776 CIRG_04872 CIRG_04872 CIRG_04892 CIRG_04892 CIRG_03436 CIRG_03436 CIRG_03435 CIRG_03435 CIRG_03440 CIRG_03440 CIRG_03691 CIRG_03691 CIRG_03555 CIRG_03555 CIRG_05472 CIRG_05472 CIRG_05917 CIRG_05917 CIRG_04380 CIRG_04380 CIRG_04120 CIRG_04120 CIRG_04490 CIRG_04490 CIRG_04428 CIRG_04428 CIRG_05261 CIRG_05261 CIRG_05266 CIRG_05266 CIRG_06412 CIRG_06412 CIRG_06642 CIRG_06642 CIRG_04924 CIRG_04924 CIRG_05731 CIRG_05731 CIRG_06957 CIRG_06957 CIRG_05369 CIRG_05369 CIRG_05911 CIRG_05911 CIRG_06095 CIRG_06095 CIRG_06696 CIRG_06696 CIRG_08022 CIRG_08022 CIRG_06330 CIRG_06330 CIRG_06424 CIRG_06424 CIRG_08352 CIRG_08352 CIRG_06985 CIRG_06985 CIRG_07175 CIRG_07175 CIRG_09441 CIRG_09441 CIRG_07480 CIRG_07480 CIRG_07949 CIRG_07949 CIRG_08385 CIRG_08385 CIRG_08927 CIRG_08927 CIRG_09137 CIRG_09137 CIRG_09266 CIRG_09266 CIRG_01362 CIRG_01362 CIRG_01617 CIRG_01617 CIRG_01866 CIRG_01866 CIRG_02186 CIRG_02186 CIRG_10367 CIRG_10367 CIRG_03374 CIRG_03374 CIRG_04923 CIRG_04923 CIRG_05303 CIRG_05303 CIRG_05663 CIRG_05663 CIRG_06288 CIRG_06288 CIRG_06503 CIRG_06503 CIRG_06648 CIRG_06648 CIRG_06928 CIRG_06928 CIRG_06933 CIRG_06933 CIRG_07063 CIRG_07063 CIRG_08153 CIRG_08153 CIRG_08903 CIRG_08903 CIRG_09637 CIRG_09637 CIRG_09405 CIRG_09405
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CIRG_00912Malic enzyme. (595 aa)
CIRG_09984Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (801 aa)
CIRG_014402-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (444 aa)
CIRG_10199Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
CIRG_017142-oxoglutarate dehydrogenase E1 component. (1063 aa)
CIRG_01754Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (483 aa)
CIRG_00730APH domain-containing protein. (287 aa)
CIRG_00860Acetyl-CoA carboxylase. (2287 aa)
CIRG_012392-oxoisovalerate dehydrogenase subunit beta. (388 aa)
CIRG_02523Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (281 aa)
CIRG_02627Fumarate hydratase. (546 aa)
CIRG_02229Uncharacterized protein. (83 aa)
CIRG_01550Aspartate aminotransferase. (427 aa)
CIRG_01163Aspartate aminotransferase. (433 aa)
CIRG_03559Methylcrotonoyl-CoA carboxylase subunit alpha. (803 aa)
CIRG_02187Uncharacterized protein. (338 aa)
CIRG_03777Succinyl-CoA ligase subunit alpha. (148 aa)
CIRG_02416ATP-citrate synthase subunit 1. (657 aa)
CIRG_10196Uncharacterized protein. (313 aa)
CIRG_02414ATP-citrate synthase. (486 aa)
CIRG_03091Citrate synthase; Belongs to the citrate synthase family. (474 aa)
CIRG_02805Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (331 aa)
CIRG_03776Succinyl-CoA synthetase beta chain. (467 aa)
CIRG_04872FAD dependent oxidoreductase. (405 aa)
CIRG_04892Acetolactate synthase catalytic subunit; Belongs to the TPP enzyme family. (611 aa)
CIRG_03436Succinate dehydrogenase flavoprotein subunit. (631 aa)
CIRG_03435WW domain containing protein. (266 aa)
CIRG_03440Succinate dehydrogenase. (186 aa)
CIRG_03691Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (381 aa)
CIRG_03555Methylcrotonoyl-CoA carboxylase beta chain. (580 aa)
CIRG_05472Threonine dehydratase catabolic. (389 aa)
CIRG_05917Aspartate aminotransferase. (474 aa)
CIRG_04380Uncharacterized protein. (198 aa)
CIRG_041202-hydroxyphytanoyl-CoA lyase; Belongs to the TPP enzyme family. (614 aa)
CIRG_04490Tricarballylate dehydrogenase. (526 aa)
CIRG_04428Dihydroxy-acid dehydratase. (613 aa)
CIRG_05261Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (455 aa)
CIRG_05266Malate dehydrogenase. (340 aa)
CIRG_06412Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
CIRG_06642Fumarate reductase. (631 aa)
CIRG_04924Propionyl-CoA carboxylase beta chain. (574 aa)
CIRG_05731Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (509 aa)
CIRG_069573-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
CIRG_05369Dihydrolipoyl dehydrogenase. (513 aa)
CIRG_05911Biotin-apoprotein ligase. (690 aa)
CIRG_06095Homoisocitrate dehydrogenase. (359 aa)
CIRG_06696Threonine dehydratase. (421 aa)
CIRG_08022Acetolactate synthase small subunit. (348 aa)
CIRG_06330Benzaldehyde lyase; Belongs to the TPP enzyme family. (597 aa)
CIRG_064243-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (373 aa)
CIRG_08352Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (459 aa)
CIRG_06985Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (194 aa)
CIRG_071752-isopropylmalate synthase. (635 aa)
CIRG_09441Branched-chain-amino-acid aminotransferase 5. (388 aa)
CIRG_07480Acetolactate synthase. (695 aa)
CIRG_07949Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
CIRG_08385Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. (251 aa)
CIRG_08927Dihydrolipoamide succinyltransferase. (484 aa)
CIRG_09137Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (647 aa)
CIRG_09266Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (404 aa)
CIRG_01362DUF1752 domain-containing protein. (580 aa)
CIRG_01617Acetyl-coenzyme A synthetase. (691 aa)
CIRG_01866Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (784 aa)
CIRG_02186Uncharacterized protein. (462 aa)
CIRG_10367L-serine dehydratase. (426 aa)
CIRG_03374Carboxyvinyl-carboxyphosphonate phosphorylmutase. (349 aa)
CIRG_04923Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (1152 aa)
CIRG_05303Dihydroxy-acid dehydratase. (614 aa)
CIRG_05663Peripheral subunit-binding (PSBD) domain-containing protein. (411 aa)
CIRG_062883-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (773 aa)
CIRG_06503Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
CIRG_06648Acetyl-CoA hydrolase. (525 aa)
CIRG_06928Auxin family protein. (582 aa)
CIRG_06933Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (564 aa)
CIRG_07063Uncharacterized protein. (183 aa)
CIRG_08153Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (417 aa)
CIRG_08903Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1192 aa)
CIRG_09637Citrate synthase; Belongs to the citrate synthase family. (473 aa)
CIRG_09405Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (330 aa)
Your Current Organism:
Coccidioides immitis RMSCC2394
NCBI taxonomy Id: 404692
Other names: C. immitis RMSCC 2394, Coccidioides immitis RMSCC 2394
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