(12 nodes) Tricarboxylic acid cycle enzyme complex network (Coccidioides immitis RMSCC2394)

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	CIRG_06503	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	CIRG_01440	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (444 aa)
	CIRG_01714	2-oxoglutarate dehydrogenase E1 component. (1063 aa)
	CIRG_00730	APH domain-containing protein. (287 aa)
	CIRG_01239	2-oxoisovalerate dehydrogenase subunit beta. (388 aa)
	CIRG_02627	Fumarate hydratase. (546 aa)
	CIRG_03777	Succinyl-CoA ligase subunit alpha. (148 aa)
	CIRG_02805	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (331 aa)
	CIRG_03776	Succinyl-CoA synthetase beta chain. (467 aa)
	CIRG_05369	Dihydrolipoyl dehydrogenase. (513 aa)
	CIRG_07985	Uncharacterized protein. (125 aa)
	CIRG_08927	Dihydrolipoamide succinyltransferase. (484 aa)

Your Current Organism:

Coccidioides immitis RMSCC2394

NCBI taxonomy Id: 404692
Other names: C. immitis RMSCC 2394, Coccidioides immitis RMSCC 2394

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIRG_00730	CIRG_01440	A0A0J6Y1U7	A0A0J6Y0V9	APH domain-containing protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.414
CIRG_00730	CIRG_01714	A0A0J6Y1U7	A0A0J6Y1K1	APH domain-containing protein.	2-oxoglutarate dehydrogenase E1 component.	0.843
CIRG_00730	CIRG_02805	A0A0J6Y1U7	A0A0J6Y8M8	APH domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.815
CIRG_00730	CIRG_03776	A0A0J6Y1U7	A0A0J6Y8Q2	APH domain-containing protein.	Succinyl-CoA synthetase beta chain.	0.687
CIRG_00730	CIRG_03777	A0A0J6Y1U7	A0A0J6Y615	APH domain-containing protein.	Succinyl-CoA ligase subunit alpha.	0.773
CIRG_00730	CIRG_05369	A0A0J6Y1U7	A0A0J6YFG4	APH domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.845
CIRG_00730	CIRG_06503	A0A0J6Y1U7	A0A0J7B9W6	APH domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.725
CIRG_00730	CIRG_08927	A0A0J6Y1U7	A0A0J6YR12	APH domain-containing protein.	Dihydrolipoamide succinyltransferase.	0.632
CIRG_01239	CIRG_01440	A0A0J6Y287	A0A0J6Y0V9	2-oxoisovalerate dehydrogenase subunit beta.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
CIRG_01239	CIRG_01714	A0A0J6Y287	A0A0J6Y1K1	2-oxoisovalerate dehydrogenase subunit beta.	2-oxoglutarate dehydrogenase E1 component.	0.854
CIRG_01239	CIRG_02805	A0A0J6Y287	A0A0J6Y8M8	2-oxoisovalerate dehydrogenase subunit beta.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.615
CIRG_01239	CIRG_03776	A0A0J6Y287	A0A0J6Y8Q2	2-oxoisovalerate dehydrogenase subunit beta.	Succinyl-CoA synthetase beta chain.	0.514
CIRG_01239	CIRG_03777	A0A0J6Y287	A0A0J6Y615	2-oxoisovalerate dehydrogenase subunit beta.	Succinyl-CoA ligase subunit alpha.	0.615
CIRG_01239	CIRG_05369	A0A0J6Y287	A0A0J6YFG4	2-oxoisovalerate dehydrogenase subunit beta.	Dihydrolipoyl dehydrogenase.	0.984
CIRG_01239	CIRG_06503	A0A0J6Y287	A0A0J7B9W6	2-oxoisovalerate dehydrogenase subunit beta.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.514
CIRG_01239	CIRG_08927	A0A0J6Y287	A0A0J6YR12	2-oxoisovalerate dehydrogenase subunit beta.	Dihydrolipoamide succinyltransferase.	0.966
CIRG_01440	CIRG_00730	A0A0J6Y0V9	A0A0J6Y1U7	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	APH domain-containing protein.	0.414
CIRG_01440	CIRG_01239	A0A0J6Y0V9	A0A0J6Y287	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-oxoisovalerate dehydrogenase subunit beta.	0.999
CIRG_01440	CIRG_01714	A0A0J6Y0V9	A0A0J6Y1K1	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	2-oxoglutarate dehydrogenase E1 component.	0.839
CIRG_01440	CIRG_02627	A0A0J6Y0V9	A0A0J6Y2R9	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Fumarate hydratase.	0.414