(47 nodes) Citric acid cycle (TCA cycle) network (Coccidioides immitis RMSCC2394)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	CIRG_09619	Choline transport protein. (526 aa)
	CIRG_08927	Dihydrolipoamide succinyltransferase. (484 aa)
	CIRG_09137	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (647 aa)
	CIRG_00349	GabA permease. (517 aa)
	CIRG_00455	GABA permease. (555 aa)
	CIRG_01866	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (784 aa)
	CIRG_03748	Polyamine transporter TPO5. (538 aa)
	CIRG_04613	GABA permease. (503 aa)
	CIRG_05993	Amino acid permease 2. (556 aa)
	CIRG_06503	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (443 aa)
	CIRG_07063	Uncharacterized protein. (183 aa)
	CIRG_08138	Choline transporter. (547 aa)
	CIRG_09637	Citrate synthase; Belongs to the citrate synthase family. (473 aa)
	CIRG_09405	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (330 aa)
	CIRG_06985	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (194 aa)
	CIRG_02070	Amino acid permease 2. (451 aa)
	CIRG_09984	Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (801 aa)
	CIRG_10199	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
	CIRG_01714	2-oxoglutarate dehydrogenase E1 component. (1063 aa)
	CIRG_00730	APH domain-containing protein. (287 aa)
	CIRG_01289	Uncharacterized protein. (882 aa)
	CIRG_02523	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (281 aa)
	CIRG_02627	Fumarate hydratase. (546 aa)
	CIRG_01913	Choline transporter. (534 aa)
	CIRG_03777	Succinyl-CoA ligase subunit alpha. (148 aa)
	CIRG_03907	NAD(P) transhydrogenase. (1082 aa)
	CIRG_03091	Citrate synthase; Belongs to the citrate synthase family. (474 aa)
	CIRG_02805	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (331 aa)
	CIRG_03776	Succinyl-CoA synthetase beta chain. (467 aa)
	CIRG_03291	Gamma-aminobutyric acid transporter. (547 aa)
	CIRG_03436	Succinate dehydrogenase flavoprotein subunit. (631 aa)
	CIRG_03435	WW domain containing protein. (266 aa)
	CIRG_03440	Succinate dehydrogenase. (186 aa)
	CIRG_03691	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (381 aa)
	CIRG_04706	Trihydroxytoluene oxygenase. (343 aa)
	CIRG_04329	Uncharacterized protein. (488 aa)
	CIRG_05266	Malate dehydrogenase. (340 aa)
	CIRG_06807	GABA transporter. (525 aa)
	CIRG_05369	Dihydrolipoyl dehydrogenase. (513 aa)
	CIRG_05640	54S ribosomal protein L49. (234 aa)
	CIRG_05644	Fumarylacetoacetate hydrolase domain-containing protein 1. (231 aa)
	CIRG_06095	Homoisocitrate dehydrogenase. (359 aa)
	CIRG_07000	Amino acid permease 2. (526 aa)
	CIRG_08061	Uncharacterized protein. (130 aa)
	CIRG_08060	GABA permease. (312 aa)
	CIRG_07949	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
	CIRG_08375	Uncharacterized protein. (554 aa)

Your Current Organism:

Coccidioides immitis RMSCC2394

NCBI taxonomy Id: 404692
Other names: C. immitis RMSCC 2394, Coccidioides immitis RMSCC 2394

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIRG_00730	CIRG_01714	A0A0J6Y1U7	A0A0J6Y1K1	APH domain-containing protein.	2-oxoglutarate dehydrogenase E1 component.	0.843
CIRG_00730	CIRG_01866	A0A0J6Y1U7	A0A0J7AWH8	APH domain-containing protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.713
CIRG_00730	CIRG_02523	A0A0J6Y1U7	A0A0J6Y2G6	APH domain-containing protein.	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.924
CIRG_00730	CIRG_02805	A0A0J6Y1U7	A0A0J6Y8M8	APH domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.815
CIRG_00730	CIRG_03091	A0A0J6Y1U7	A0A0J6Y8M5	APH domain-containing protein.	Citrate synthase; Belongs to the citrate synthase family.	0.754
CIRG_00730	CIRG_03435	A0A0J6Y1U7	A0A0J6YAD9	APH domain-containing protein.	WW domain containing protein.	0.803
CIRG_00730	CIRG_03436	A0A0J6Y1U7	A0A0J6Y9P0	APH domain-containing protein.	Succinate dehydrogenase flavoprotein subunit.	0.807
CIRG_00730	CIRG_03440	A0A0J6Y1U7	A0A0J6YAE4	APH domain-containing protein.	Succinate dehydrogenase.	0.811
CIRG_00730	CIRG_03691	A0A0J6Y1U7	A0A0J6YAG8	APH domain-containing protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.666
CIRG_00730	CIRG_03776	A0A0J6Y1U7	A0A0J6Y8Q2	APH domain-containing protein.	Succinyl-CoA synthetase beta chain.	0.687
CIRG_00730	CIRG_03777	A0A0J6Y1U7	A0A0J6Y615	APH domain-containing protein.	Succinyl-CoA ligase subunit alpha.	0.773
CIRG_00730	CIRG_04706	A0A0J6Y1U7	A0A0J6YBC8	APH domain-containing protein.	Trihydroxytoluene oxygenase.	0.455
CIRG_00730	CIRG_05266	A0A0J6Y1U7	A0A0J6YD23	APH domain-containing protein.	Malate dehydrogenase.	0.859
CIRG_00730	CIRG_05369	A0A0J6Y1U7	A0A0J6YFG4	APH domain-containing protein.	Dihydrolipoyl dehydrogenase.	0.845
CIRG_00730	CIRG_05640	A0A0J6Y1U7	A0A0J6YFZ5	APH domain-containing protein.	54S ribosomal protein L49.	0.569
CIRG_00730	CIRG_05644	A0A0J6Y1U7	A0A0J6YGD0	APH domain-containing protein.	Fumarylacetoacetate hydrolase domain-containing protein 1.	0.669
CIRG_00730	CIRG_06095	A0A0J6Y1U7	A0A0J6YH60	APH domain-containing protein.	Homoisocitrate dehydrogenase.	0.603
CIRG_00730	CIRG_06503	A0A0J6Y1U7	A0A0J7B9W6	APH domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.725
CIRG_00730	CIRG_06985	A0A0J6Y1U7	A0A0J6YJM8	APH domain-containing protein.	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit.	0.870
CIRG_00730	CIRG_07063	A0A0J6Y1U7	A0A0J7BBE9	APH domain-containing protein.	Uncharacterized protein.	0.811