STRINGSTRING
SIS54622.1 SIS54622.1 SIS54637.1 SIS54637.1 SIS57883.1 SIS57883.1 SIS58171.1 SIS58171.1 SIS58186.1 SIS58186.1 metAA metAA SIS62496.1 SIS62496.1 SIS71193.1 SIS71193.1 metZ metZ SIS72832.1 SIS72832.1 SIS69382.1 SIS69382.1 SIS75120.1 SIS75120.1 metK metK SIS80367.1 SIS80367.1 SIS80389.1 SIS80389.1 SIS80404.1 SIS80404.1 SIS80415.1 SIS80415.1 SIS80424.1 SIS80424.1 SIS80441.1 SIS80441.1 glyA glyA cysS cysS SIS83853.1 SIS83853.1 SIS87882.1 SIS87882.1 SIS87892.1 SIS87892.1 SIS88118.1 SIS88118.1 SIS88969.1 SIS88969.1 SIS88978.1 SIS88978.1 SIS88990.1 SIS88990.1 metK-2 metK-2 SIS89012.1 SIS89012.1 SIT01011.1 SIT01011.1 SIT04514.1 SIT04514.1 SIT10425.1 SIT10425.1 SIT10864.1 SIT10864.1 SIT14844.1 SIT14844.1 SIT16402.1 SIT16402.1 SIT19167.1 SIT19167.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIS54622.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
SIS54637.1Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (402 aa)
SIS57883.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
SIS58171.1Hypothetical protein. (143 aa)
SIS58186.1Aspartate aminotransferase. (371 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (308 aa)
SIS62496.15-aminolevulinate synthase. (409 aa)
SIS71193.1L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (395 aa)
SIS72832.1Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (390 aa)
SIS69382.1Methionine-gamma-lyase. (399 aa)
SIS75120.1Adenosylhomocysteinase. (82 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
SIS80367.1Cytosine/adenosine deaminase. (450 aa)
SIS80389.1Ornithine cyclodeaminase. (320 aa)
SIS80404.1D-3-hydroxyaspartate aldolase. (387 aa)
SIS80415.1Threonine dehydratase. (315 aa)
SIS80424.1Serine-glyoxylate aminotransferase apoenzyme. (395 aa)
SIS80441.1Transcriptional regulator, IclR family. (267 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
cysScysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (460 aa)
SIS83853.1Cysteine synthase A. (343 aa)
SIS87882.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (903 aa)
SIS87892.1Methionine synthase (B12-dependent). (347 aa)
SIS88118.1Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (390 aa)
SIS88969.15,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. (292 aa)
SIS88978.15-methyltetrahydrofolate--homocysteine methyltransferase. (358 aa)
SIS88990.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (891 aa)
metK-2Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (394 aa)
SIS89012.1Adenosylhomocysteinase. (47 aa)
SIT01011.1Serine O-acetyltransferase. (275 aa)
SIT04514.1L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
SIT10425.1Phosphoserine phosphatase. (292 aa)
SIT10864.1Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. (286 aa)
SIT14844.1Cysteine synthase A. (212 aa)
SIT16402.1Serine O-acetyltransferase. (260 aa)
SIT19167.1Adenosylhomocysteinase. (403 aa)
Your Current Organism:
Paracoccus saliphilus
NCBI taxonomy Id: 405559
Other names: CCTCC AB 206074, DSM 18447, KCTC 22163, P. saliphilus, Paracoccus saliphilus Wang et al. 2009, YIM 90738
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