STRINGSTRING
SIS64117.1 SIS64117.1 SIS88953.1 SIS88953.1 SIS87438.1 SIS87438.1 SIS90969.1 SIS90969.1 SIS91131.1 SIS91131.1 SIS89970.1 SIS89970.1 SIS90173.1 SIS90173.1 SIS90184.1 SIS90184.1 SIS90193.1 SIS90193.1 kbl kbl gpmI gpmI SIT03155.1 SIT03155.1 SIT03184.1 SIT03184.1 SIT03193.1 SIT03193.1 SIT03205.1 SIT03205.1 SIT05045.1 SIT05045.1 SIT04514.1 SIT04514.1 SIT06692.1 SIT06692.1 SIT06702.1 SIT06702.1 SIT06759.1 SIT06759.1 glyA-2 glyA-2 SIT07552.1 SIT07552.1 SIT07587.1 SIT07587.1 SIT07798.1 SIT07798.1 SIT07808.1 SIT07808.1 gcvP gcvP gcvH gcvH SIT08295.1 SIT08295.1 trpB-2 trpB-2 SIT09388.1 SIT09388.1 SIT10425.1 SIT10425.1 SIT10900.1 SIT10900.1 SIT14268.1 SIT14268.1 SIT14314.1 SIT14314.1 SIT16434.1 SIT16434.1 SIT16299.1 SIT16299.1 SIT16714.1 SIT16714.1 SIT16718.1 SIT16718.1 SIT16727.1 SIT16727.1 SIT16735.1 SIT16735.1 SIT17433.1 SIT17433.1 SIS54637.1 SIS54637.1 SIS55708.1 SIS55708.1 SIS56705.1 SIS56705.1 SIS56846.1 SIS56846.1 SIS58186.1 SIS58186.1 SIS63083.1 SIS63083.1 SIS65539.1 SIS65539.1 ilvA ilvA trpB trpB trpA trpA SIS50612.1 SIS50612.1 SIS50700.1 SIS50700.1 SIS64892.1 SIS64892.1 SIS51861.1 SIS51861.1 pqqC pqqC asd asd SIS53818.1 SIS53818.1 SIS54622.1 SIS54622.1 SIT18116.1 SIT18116.1 SIT18111.1 SIT18111.1 glyA-3 glyA-3 SIT17991.1 SIT17991.1 SIT17714.1 SIT17714.1 SIS66017.1 SIS66017.1 SIS66175.1 SIS66175.1 SIS66413.1 SIS66413.1 SIS66936.1 SIS66936.1 SIS62496.1 SIS62496.1 SIS62601.1 SIS62601.1 SIS71193.1 SIS71193.1 SIS71716.1 SIS71716.1 SIS71832.1 SIS71832.1 SIS71860.1 SIS71860.1 SIS71867.1 SIS71867.1 SIS69283.1 SIS69283.1 SIS72802.1 SIS72802.1 SIS73460.1 SIS73460.1 SIS76900.1 SIS76900.1 SIS76117.1 SIS76117.1 SIS80404.1 SIS80404.1 SIS80415.1 SIS80415.1 SIS80424.1 SIS80424.1 glyA glyA ectC ectC SIS83156.1 SIS83156.1 ectA ectA SIS87857.1 SIS87857.1 SIS88118.1 SIS88118.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIS64117.1Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (528 aa)
SIS88953.1Glycine/sarcosine N-methyltransferase. (562 aa)
SIS87438.1Arsenate reductase. (117 aa)
SIS90969.1Dimethylglycine dehydrogenase; Belongs to the GcvT family. (806 aa)
SIS91131.1Probable phosphoglycerate mutase. (218 aa)
SIS89970.1Xaa-Pro dipeptidase. (388 aa)
SIS90173.1Hypothetical protein. (195 aa)
SIS90184.1N-methylglutamate dehydrogenase subunit C; Belongs to the GcvT family. (951 aa)
SIS90193.1N-methylglutamate dehydrogenase subunit B. (86 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
SIT03155.1Sarcosine oxidase subunit beta. (421 aa)
SIT03184.1Sarcosine oxidase subunit delta. (108 aa)
SIT03193.1Sarcosine oxidase subunit alpha; Belongs to the GcvT family. (976 aa)
SIT03205.1Sarcosine oxidase subunit gamma. (172 aa)
SIT05045.1Transmembrane secretion effector. (423 aa)
SIT04514.1L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
SIT06692.1Mercuric reductase. (383 aa)
SIT06702.1Mercuric reductase. (87 aa)
SIT06759.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (716 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT07552.1Aspartate aminotransferase. (415 aa)
SIT07587.1Hydroxypyruvate reductase. (413 aa)
SIT07798.1Aminomethyltransferase; Belongs to the GcvT family. (377 aa)
SIT07808.1Aminomethyltransferase; Belongs to the GcvT family. (788 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (944 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (119 aa)
SIT08295.1Aminomethyltransferase. (374 aa)
trpB-2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (410 aa)
SIT09388.1Helix-turn-helix. (68 aa)
SIT10425.1Phosphoserine phosphatase. (292 aa)
SIT10900.1Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (183 aa)
SIT14268.1Glyoxylate/hydroxypyruvate reductase A. (310 aa)
SIT14314.1Sarcosine oxidase subunit beta. (380 aa)
SIT16434.1Glyoxylate/hydroxypyruvate reductase A. (309 aa)
SIT16299.14-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (495 aa)
SIT16714.1Sarcosine oxidase subunit beta. (417 aa)
SIT16718.1Sarcosine oxidase subunit delta. (99 aa)
SIT16727.1Sarcosine oxidase subunit alpha; Belongs to the GcvT family. (996 aa)
SIT16735.1Sarcosine oxidase subunit gamma. (178 aa)
SIT17433.1Hypothetical protein. (229 aa)
SIS54637.1Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (402 aa)
SIS55708.1Aspartate kinase; Belongs to the aspartokinase family. (418 aa)
SIS56705.1Glycine/D-amino acid oxidase. (401 aa)
SIS56846.1Choline dehydrogenase. (546 aa)
SIS58186.1Aspartate aminotransferase. (371 aa)
SIS63083.1Xaa-Pro aminopeptidase. (600 aa)
SIS65539.1Dihydrolipoamide dehydrogenase. (464 aa)
ilvAL-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (408 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (265 aa)
SIS50612.1Rieske 2Fe-2S family protein. (410 aa)
SIS50700.1Sarcosine oxidase subunit gamma. (184 aa)
SIS64892.1Homoserine dehydrogenase. (429 aa)
SIS51861.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
pqqCPyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (249 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
SIS53818.1Predicted arabinose efflux permease, MFS family. (546 aa)
SIS54622.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
SIT18116.1Aspartate aminotransferase. (416 aa)
SIT18111.1Hydroxypyruvate reductase. (418 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT17991.1Arsenate reductase, glutaredoxin family; Belongs to the ArsC family. (114 aa)
SIT17714.1Threonine dehydratase. (325 aa)
SIS66017.1CDP-diacylglycerol---serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (248 aa)
SIS66175.1Phenylpropionate dioxygenase, large terminal subunit. (384 aa)
SIS66413.1Hypothetical protein. (289 aa)
SIS66936.1Dihydrolipoamide dehydrogenase. (463 aa)
SIS62496.15-aminolevulinate synthase. (409 aa)
SIS62601.1Glyoxylate/hydroxypyruvate reductase A. (302 aa)
SIS71193.1L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
SIS71716.1Succinate semialdehyde dehydrogenase. (486 aa)
SIS71832.1Threonine dehydratase. (318 aa)
SIS71860.1Ectoine hydrolase. (398 aa)
SIS71867.1N-alpha-acetyl-L-2,4-diaminobutyrate deacetylase. (334 aa)
SIS69283.1Dihydrolipoamide dehydrogenase. (561 aa)
SIS72802.1Choline dehydrogenase. (538 aa)
SIS73460.1Dimethylglycine dehydrogenase; Belongs to the GcvT family. (833 aa)
SIS76900.1Xaa-Pro aminopeptidase. (364 aa)
SIS76117.1L-threonine synthase. (460 aa)
SIS80404.1D-3-hydroxyaspartate aldolase. (387 aa)
SIS80415.1Threonine dehydratase. (315 aa)
SIS80424.1Serine-glyoxylate aminotransferase apoenzyme. (395 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
ectCEctoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (131 aa)
SIS83156.1Aspartate kinase. (474 aa)
ectADiaminobutyrate acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (181 aa)
SIS87857.1Rieske 2Fe-2S family protein. (410 aa)
SIS88118.1Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (390 aa)
Your Current Organism:
Paracoccus saliphilus
NCBI taxonomy Id: 405559
Other names: CCTCC AB 206074, DSM 18447, KCTC 22163, P. saliphilus, Paracoccus saliphilus Wang et al. 2009, YIM 90738
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