STRINGSTRING
SIS50509.1 SIS50509.1 SIS51101.1 SIS51101.1 SIS51116.1 SIS51116.1 SIS51131.1 SIS51131.1 SIS51165.1 SIS51165.1 SIS51624.1 SIS51624.1 SIS52679.1 SIS52679.1 SIS52799.1 SIS52799.1 SIS53061.1 SIS53061.1 SIS53938.1 SIS53938.1 SIS53953.1 SIS53953.1 SIS53969.1 SIS53969.1 SIS54756.1 SIS54756.1 SIS55863.1 SIS55863.1 SIS58186.1 SIS58186.1 SIS58211.1 SIS58211.1 SIS58385.1 SIS58385.1 glcB glcB SIS63105.1 SIS63105.1 SIS63761.1 SIS63761.1 SIS63784.1 SIS63784.1 acsA acsA SIS64719.1 SIS64719.1 SIS65332.1 SIS65332.1 SIS65369.1 SIS65369.1 mdh mdh SIS65539.1 SIS65539.1 SIS66413.1 SIS66413.1 SIS66510.1 SIS66510.1 SIS66936.1 SIS66936.1 SIS62601.1 SIS62601.1 SIS70272.1 SIS70272.1 SIS71159.1 SIS71159.1 SIS69283.1 SIS69283.1 SIS73396.1 SIS73396.1 SIS73522.1 SIS73522.1 SIS77150.1 SIS77150.1 SIS75295.1 SIS75295.1 SIS76012.1 SIS76012.1 SIS80424.1 SIS80424.1 SIS80449.1 SIS80449.1 glyA glyA SIS79492.1 SIS79492.1 SIS79568.1 SIS79568.1 SIS84378.1 SIS84378.1 SIS83734.1 SIS83734.1 SIS83754.1 SIS83754.1 SIS88118.1 SIS88118.1 SIS88405.1 SIS88405.1 SIS88833.1 SIS88833.1 SIS87438.1 SIS87438.1 SIS91151.1 SIS91151.1 SIS94092.1 SIS94092.1 SIS94641.1 SIS94641.1 SIS92698.1 SIS92698.1 SIS92827.1 SIS92827.1 SIS92558.1 SIS92558.1 SIS92569.1 SIS92569.1 SIS96932.1 SIS96932.1 SIS95851.1 SIS95851.1 SIS96039.1 SIS96039.1 SIS96065.1 SIS96065.1 SIS96177.1 SIS96177.1 SIS98874.1 SIS98874.1 SIS98915.1 SIS98915.1 SIS98966.1 SIS98966.1 SIT02860.1 SIT02860.1 SIT03380.1 SIT03380.1 SIT03647.1 SIT03647.1 SIT03656.1 SIT03656.1 SIT06692.1 SIT06692.1 SIT06702.1 SIT06702.1 SIT06759.1 SIT06759.1 glyA-2 glyA-2 SIT07510.1 SIT07510.1 sucD-3 sucD-3 sucC-3 sucC-3 SIT07552.1 SIT07552.1 SIT07575.1 SIT07575.1 SIT07587.1 SIT07587.1 SIT07798.1 SIT07798.1 SIT07808.1 SIT07808.1 purU purU SIT07900.1 SIT07900.1 gcvP gcvP gcvH gcvH SIT08295.1 SIT08295.1 SIT09460.1 SIT09460.1 SIT09997.1 SIT09997.1 SIT11544.1 SIT11544.1 SIT12330.1 SIT12330.1 SIT14268.1 SIT14268.1 SIT14455.1 SIT14455.1 SIT16434.1 SIT16434.1 SIT16751.1 SIT16751.1 SIT16760.1 SIT16760.1 SIT16768.1 SIT16768.1 SIT16782.1 SIT16782.1 SIT17433.1 SIT17433.1 SIT17978.1 SIT17978.1 SIT17991.1 SIT17991.1 glyA-3 glyA-3 SIT18103.1 SIT18103.1 SIT18111.1 SIT18111.1 SIT18116.1 SIT18116.1 SIT18136.1 SIT18136.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIS50509.1Phosphoglycolate phosphatase. (229 aa)
SIS51101.1Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (992 aa)
SIS51116.1Formate dehydrogenase beta subunit. (197 aa)
SIS51131.1Formate dehydrogenase gamma subunit. (393 aa)
SIS51165.1Formate dehydrogenase major subunit. (923 aa)
SIS51624.1Uncharacterized protein. (267 aa)
SIS52679.1Hypothetical protein. (109 aa)
SIS52799.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
SIS53061.1Glutamate--putrescine ligase; Belongs to the glutamine synthetase family. (443 aa)
SIS53938.1Glycolate oxidase. (483 aa)
SIS53953.1Glycolate oxidase FAD binding subunit. (377 aa)
SIS53969.1Glycolate oxidase iron-sulfur subunit. (432 aa)
SIS54756.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (388 aa)
SIS55863.1beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (318 aa)
SIS58186.1Aspartate aminotransferase. (371 aa)
SIS58211.1L-glutamine synthetase. (452 aa)
SIS58385.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (718 aa)
SIS63105.1Citrate synthase; Belongs to the citrate synthase family. (430 aa)
SIS63761.1Acyl dehydratase. (284 aa)
SIS63784.1Acetyl-CoA acetyltransferase. (383 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SIS64719.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
SIS65332.1L-erythro-3-methylmalyl-CoA dehydratase. (344 aa)
SIS65369.1(3S)-malyl-CoA thioesterase; Belongs to the HpcH/HpaI aldolase family. (283 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
SIS65539.1Dihydrolipoamide dehydrogenase. (464 aa)
SIS66413.1Hypothetical protein. (289 aa)
SIS66510.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (368 aa)
SIS66936.1Dihydrolipoamide dehydrogenase. (463 aa)
SIS62601.1Glyoxylate/hydroxypyruvate reductase A. (302 aa)
SIS70272.1Methylmalonyl-CoA mutase, cobalamin-binding subunit. (579 aa)
SIS71159.13-hydroxybutyryl-CoA dehydratase. (147 aa)
SIS69283.1Dihydrolipoamide dehydrogenase. (561 aa)
SIS73396.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa)
SIS73522.1Uncharacterized conserved protein YkwD, contains CAP (CSP/antigen 5/PR1) domain. (178 aa)
SIS77150.1methylmalonyl-CoA epimerase /ethylmalonyl-CoA epimerase. (134 aa)
SIS75295.1Acyl dehydratase. (157 aa)
SIS76012.1Acetyl esterase/lipase. (262 aa)
SIS80424.1Serine-glyoxylate aminotransferase apoenzyme. (395 aa)
SIS80449.1(2S)-methylsuccinyl-CoA dehydrogenase. (535 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIS79492.1acetyl-CoA synthetase. (517 aa)
SIS79568.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (307 aa)
SIS84378.12-keto-3-deoxy-phosphogluconate aldolase. (214 aa)
SIS83734.1(R)-ethylmalonyl-CoA mutase. (652 aa)
SIS83754.1crotonyl-CoA carboxylase/reductase. (428 aa)
SIS88118.1Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (390 aa)
SIS88405.1Uncharacterized conserved protein YkwD, contains CAP (CSP/antigen 5/PR1) domain. (171 aa)
SIS88833.1Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
SIS87438.1Arsenate reductase. (117 aa)
SIS91151.1Acyl dehydratase. (156 aa)
SIS94092.1Glutamate--putrescine ligase; Belongs to the glutamine synthetase family. (449 aa)
SIS94641.1Hydroxypyruvate isomerase; Belongs to the hyi family. (251 aa)
SIS92698.1Ribulose-bisphosphate carboxylase large chain; Belongs to the RuBisCO large chain family. (415 aa)
SIS92827.1Phosphoglycolate phosphatase. (218 aa)
SIS92558.1Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily protein. (179 aa)
SIS92569.1Ribulose-bisphosphate carboxylase large chain; Belongs to the RuBisCO large chain family. (421 aa)
SIS96932.1Acyl dehydratase. (152 aa)
SIS95851.1Formiminoglutamase. (264 aa)
SIS96039.1Kynurenine formamidase. (260 aa)
SIS96065.1Acetyl-CoA acetyltransferase. (390 aa)
SIS96177.1Kynurenine formamidase. (263 aa)
SIS98874.1methylmalonyl-CoA mutase. (711 aa)
SIS98915.1Biotin carboxyl carrier protein /biotin carboxylase. (665 aa)
SIS98966.1propionyl-CoA carboxylase carboxyltransferase subunit. (510 aa)
SIT02860.1Acetamidase/Formamidase family protein. (209 aa)
SIT03380.1N-formylglutamate amidohydrolase. (283 aa)
SIT03647.13-oxoacyl-[acyl-carrier-protein] reductase. (241 aa)
SIT03656.1acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
SIT06692.1Mercuric reductase. (383 aa)
SIT06702.1Mercuric reductase. (87 aa)
SIT06759.1Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (716 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT07510.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
sucD-3Malate thiokinase small subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
sucC-3Malate thiokinase large subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
SIT07552.1Aspartate aminotransferase. (415 aa)
SIT07575.1beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (324 aa)
SIT07587.1Hydroxypyruvate reductase. (413 aa)
SIT07798.1Aminomethyltransferase; Belongs to the GcvT family. (377 aa)
SIT07808.1Aminomethyltransferase; Belongs to the GcvT family. (788 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
SIT07900.1Gamma-glutamylmethylamide synthetase; Belongs to the glutamine synthetase family. (434 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (944 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (119 aa)
SIT08295.1Aminomethyltransferase. (374 aa)
SIT09460.1Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (765 aa)
SIT09997.1acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
SIT11544.1L-glutamine synthetase. (468 aa)
SIT12330.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
SIT14268.1Glyoxylate/hydroxypyruvate reductase A. (310 aa)
SIT14455.1L-glutamine synthetase. (453 aa)
SIT16434.1Glyoxylate/hydroxypyruvate reductase A. (309 aa)
SIT16751.1Formate dehydrogenase gamma subunit. (158 aa)
SIT16760.1Formate dehydrogenase beta subunit. (505 aa)
SIT16768.1Formate dehydrogenase alpha subunit. (968 aa)
SIT16782.1Formate dehydrogenase delta subunit. (66 aa)
SIT17433.1Hypothetical protein. (229 aa)
SIT17978.1Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (228 aa)
SIT17991.1Arsenate reductase, glutaredoxin family; Belongs to the ArsC family. (114 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT18103.1beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (325 aa)
SIT18111.1Hydroxypyruvate reductase. (418 aa)
SIT18116.1Aspartate aminotransferase. (416 aa)
SIT18136.1Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
Your Current Organism:
Paracoccus saliphilus
NCBI taxonomy Id: 405559
Other names: CCTCC AB 206074, DSM 18447, KCTC 22163, P. saliphilus, Paracoccus saliphilus Wang et al. 2009, YIM 90738
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