STRINGSTRING
SIT06251.1 SIT06251.1 SIT18392.1 SIT18392.1 SIT18116.1 SIT18116.1 SIT18111.1 SIT18111.1 glyA-3 glyA-3 SIT18144.1 SIT18144.1 SIT17728.1 SIT17728.1 SIT16782.1 SIT16782.1 SIT16768.1 SIT16768.1 SIT16760.1 SIT16760.1 SIT16751.1 SIT16751.1 SIT16299.1 SIT16299.1 gfa-2 gfa-2 SIT10900.1 SIT10900.1 eno eno SIT10425.1 SIT10425.1 SIT09460.1 SIT09460.1 SIT07941.1 SIT07941.1 SIT07929.1 SIT07929.1 SIT07916.1 SIT07916.1 SIT07820.1 SIT07820.1 SIT07587.1 SIT07587.1 SIT07575.1 SIT07575.1 SIT07552.1 SIT07552.1 sucC-3 sucC-3 sucD-3 sucD-3 SIT07495.1 SIT07495.1 glyA-2 glyA-2 SIT06528.1 SIT06528.1 SIT05477.1 SIT05477.1 SIT03086.1 SIT03086.1 gpmI gpmI SIS98567.1 SIS98567.1 SIS95553.1 SIS95553.1 SIS93403.1 SIS93403.1 SIS89936.1 SIS89936.1 SIS91375.1 SIS91375.1 SIS91131.1 SIS91131.1 SIS89947.1 SIS89947.1 SIS88118.1 SIS88118.1 SIS79492.1 SIS79492.1 glyA glyA SIS80424.1 SIS80424.1 SIS76072.1 SIS76072.1 fbp fbp SIS77735.1 SIS77735.1 SIS69938.1 SIS69938.1 SIS73080.1 SIS73080.1 SIS71948.1 SIS71948.1 SIS70832.1 SIS70832.1 SIS65589.1 SIS65589.1 mdh mdh acsA acsA SIS63051.1 SIS63051.1 SIS58186.1 SIS58186.1 SIS49685.1 SIS49685.1 SIS49654.1 SIS49654.1 SIS49635.1 SIS49635.1 SIS49622.1 SIS49622.1 SIS49593.1 SIS49593.1 gfa gfa SIS55863.1 SIS55863.1 SIS55080.1 SIS55080.1 SIS54637.1 SIS54637.1 SIS54622.1 SIS54622.1 SIS52679.1 SIS52679.1 SIS51861.1 SIS51861.1 SIS51165.1 SIS51165.1 SIS51131.1 SIS51131.1 SIS51116.1 SIS51116.1 SIS51101.1 SIS51101.1 SIS51073.1 SIS51073.1 SIS51029.1 SIS51029.1 SIS50675.1 SIS50675.1 SIS50662.1 SIS50662.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIT06251.1Uncharacterized conserved protein. (130 aa)
SIT18392.1Putative flavoprotein involved in K+ transport. (599 aa)
SIT18116.1Aspartate aminotransferase. (416 aa)
SIT18111.1Hydroxypyruvate reductase. (418 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT18144.1Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (884 aa)
SIT17728.1Uncharacterized conserved protein. (156 aa)
SIT16782.1Formate dehydrogenase delta subunit. (66 aa)
SIT16768.1Formate dehydrogenase alpha subunit. (968 aa)
SIT16760.1Formate dehydrogenase beta subunit. (505 aa)
SIT16751.1Formate dehydrogenase gamma subunit. (158 aa)
SIT16299.14-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (495 aa)
gfa-2S-(hydroxymethyl)glutathione synthase; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (246 aa)
SIT10900.1Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (183 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
SIT10425.1Phosphoserine phosphatase. (292 aa)
SIT09460.1Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (765 aa)
SIT07941.1N-methylglutamate synthase subunit A. (295 aa)
SIT07929.1N-methylglutamate synthase subunit B. (227 aa)
SIT07916.1N-methylglutamate synthase subunit C precursor; Belongs to the glutamate synthase family. (441 aa)
SIT07820.1Trimethylamine monooxygenase. (447 aa)
SIT07587.1Hydroxypyruvate reductase. (413 aa)
SIT07575.1beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (324 aa)
SIT07552.1Aspartate aminotransferase. (415 aa)
sucC-3Malate thiokinase large subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (399 aa)
sucD-3Malate thiokinase small subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
SIT07495.1Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (888 aa)
glyA-2Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIT06528.1Ca-activated chloride channel family protein. (316 aa)
SIT05477.12,4-dienoyl-CoA reductase. (666 aa)
SIT03086.16-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (316 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
SIS98567.1Coenzyme F420-reducing hydrogenase, beta subunit. (1526 aa)
SIS95553.1Uncharacterized conserved protein. (134 aa)
SIS93403.1Uncharacterized conserved protein. (137 aa)
SIS89936.1N-methylglutamate dehydrogenase subunit B. (91 aa)
SIS91375.1Hypothetical protein. (678 aa)
SIS91131.1Probable phosphoglycerate mutase. (218 aa)
SIS89947.1Sarcosine oxidase subunit beta. (417 aa)
SIS88118.1Alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase. (390 aa)
SIS79492.1acetyl-CoA synthetase. (517 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
SIS80424.1Serine-glyoxylate aminotransferase apoenzyme. (395 aa)
SIS76072.1Glutamate synthase domain-containing protein 2; Belongs to the glutamate synthase family. (548 aa)
fbpD-fructose 1,6-bisphosphatase; Belongs to the FBPase class 1 family. (329 aa)
SIS77735.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (344 aa)
SIS69938.1Dimethylamine/trimethylamine dehydrogenase. (683 aa)
SIS73080.1Uncharacterized conserved protein. (115 aa)
SIS71948.1Uncharacterized conserved protein. (126 aa)
SIS70832.1Uncharacterized conserved protein. (141 aa)
SIS65589.1Fructose-bisphosphate aldolase. (307 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
SIS63051.1Fructose-1,6-bisphosphatase II / sedoheptulose-1,7-bisphosphatase. (321 aa)
SIS58186.1Aspartate aminotransferase. (371 aa)
SIS49685.1Polyketide cyclase / dehydrase and lipid transport. (185 aa)
SIS49654.1Amino acid ABC transporter substrate-binding protein, PAAT family. (271 aa)
SIS49635.1PQQ-dependent dehydrogenase, methanol/ethanol family. (635 aa)
SIS49622.1S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa)
SIS49593.1S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
gfaS-(hydroxymethyl)glutathione synthase; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (194 aa)
SIS55863.1beta-methylmalyl-CoA/L-malyl-CoA lyase; Belongs to the HpcH/HpaI aldolase family. (318 aa)
SIS55080.1Phosphotransacetylase. (318 aa)
SIS54637.1Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (402 aa)
SIS54622.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa)
SIS52679.1Hypothetical protein. (109 aa)
SIS51861.1Lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
SIS51165.1Formate dehydrogenase major subunit. (923 aa)
SIS51131.1Formate dehydrogenase gamma subunit. (393 aa)
SIS51116.1Formate dehydrogenase beta subunit. (197 aa)
SIS51101.1Formate dehydrogenase major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (992 aa)
SIS51073.1Chaperone TorD involved in molybdoenzyme TorA maturation. (223 aa)
SIS51029.14Fe-4S dicluster domain-containing protein. (647 aa)
SIS50675.1Sarcosine oxidase subunit delta. (96 aa)
SIS50662.1N-methylglutamate dehydrogenase subunit A precursor. (416 aa)
Your Current Organism:
Paracoccus saliphilus
NCBI taxonomy Id: 405559
Other names: CCTCC AB 206074, DSM 18447, KCTC 22163, P. saliphilus, Paracoccus saliphilus Wang et al. 2009, YIM 90738
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