STRINGSTRING
SMC53977.1 SMC53977.1 SMC58692.1 SMC58692.1 SMC59595.1 SMC59595.1 SMC65917.1 SMC65917.1 SMC65932.1 SMC65932.1 sucC sucC sucD sucD mdh mdh SMC67687.1 SMC67687.1 SMC67883.1 SMC67883.1 SMC67894.1 SMC67894.1 SMC67901.1 SMC67901.1 SMC67910.1 SMC67910.1 SMC68145.1 SMC68145.1 SMC68157.1 SMC68157.1 SMC68168.1 SMC68168.1 SMC69400.1 SMC69400.1 SMC70820.1 SMC70820.1 SMC80735.1 SMC80735.1 SMC82526.1 SMC82526.1 SMC88015.1 SMC88015.1 SMC88173.1 SMC88173.1 SMC88176.1 SMC88176.1 ilvD ilvD SMC90016.1 SMC90016.1 sucD-2 sucD-2 sucC-2 sucC-2 SMC96391.1 SMC96391.1 SMD01630.1 SMD01630.1 ilvD-2 ilvD-2 SMD02064.1 SMD02064.1 SMD02066.1 SMD02066.1 ilvC ilvC leuB leuB SMD02140.1 SMD02140.1 leuC leuC leuD leuD SMD02462.1 SMD02462.1 SMD02727.1 SMD02727.1 SMD06887.1 SMD06887.1 SMD07085.1 SMD07085.1 SMD07951.1 SMD07951.1 pckG pckG SMD11931.1 SMD11931.1 SMD13988.1 SMD13988.1 SMD14549.1 SMD14549.1 SMD14552.1 SMD14552.1 SMD14556.1 SMD14556.1 SMD14560.1 SMD14560.1 SMD14882.1 SMD14882.1 SMD15256.1 SMD15256.1 SMD15259.1 SMD15259.1 SMD18280.1 SMD18280.1 SMD18325.1 SMD18325.1 SMD19226.1 SMD19226.1 SMD20910.1 SMD20910.1 acsA acsA leuA leuA fumC fumC SMD22519.1 SMD22519.1 SMD23106.1 SMD23106.1 SMD23107.1 SMD23107.1 SMD23365.1 SMD23365.1 SMD24013.1 SMD24013.1 SMD24248.1 SMD24248.1 SMD24686.1 SMD24686.1 SMD25092.1 SMD25092.1 SMD25234.1 SMD25234.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMC53977.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase. (445 aa)
SMC58692.1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (567 aa)
SMC59595.1Acyl-CoA synthetase (NDP forming). (662 aa)
SMC65917.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (349 aa)
SMC65932.12-oxoglutarate ferredoxin oxidoreductase subunit alpha. (612 aa)
sucCsuccinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (326 aa)
SMC67687.1Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa)
SMC67883.1Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. (260 aa)
SMC67894.1Succinate dehydrogenase subunit A. (584 aa)
SMC67901.1Succinate dehydrogenase / fumarate reductase membrane anchor subunit. (135 aa)
SMC67910.1Succinate dehydrogenase subunit C. (140 aa)
SMC68145.1Aldehyde dehydrogenase family protein. (287 aa)
SMC68157.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (475 aa)
SMC68168.1Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (318 aa)
SMC69400.1Malate dehydrogenase (oxaloacetate-decarboxylating). (398 aa)
SMC70820.1Pyruvate oxidase; Belongs to the TPP enzyme family. (585 aa)
SMC80735.1Pyruvate, phosphate dikinase. (448 aa)
SMC82526.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (472 aa)
SMC88015.14-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
SMC88173.1Citrate synthase; Belongs to the citrate synthase family. (369 aa)
SMC88176.1Citrate synthase. (373 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa)
SMC90016.1Pyruvate, water dikinase. (742 aa)
sucD-2succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
sucC-2succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (366 aa)
SMC96391.1Fumarase, class II. (476 aa)
SMD01630.12-Methylisocitrate lyase, PEP mutase family. (268 aa)
ilvD-2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa)
SMD02064.1Acetolactate synthase, large subunit. (578 aa)
SMD02066.1Acetolactate synthase, small subunit. (168 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (345 aa)
SMD02140.12-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa)
leuD3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
SMD02462.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa)
SMD02727.1Malate synthase; Belongs to the malate synthase family. (494 aa)
SMD06887.14-amino-4-deoxychorismate lyase. (280 aa)
SMD07085.1Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase. (497 aa)
SMD07951.1Glycolate oxidase. (456 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (603 aa)
SMD11931.1Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (528 aa)
SMD13988.1Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (551 aa)
SMD14549.1Succinate dehydrogenase / fumarate reductase iron-sulfur subunit. (249 aa)
SMD14552.1Succinate dehydrogenase / fumarate reductase flavoprotein subunit. (622 aa)
SMD14556.1Hypothetical protein. (254 aa)
SMD14560.1Hypothetical protein. (96 aa)
SMD14882.1Branched-chain amino acid aminotransferase. (363 aa)
SMD15256.1Acetolactate synthase, small subunit. (88 aa)
SMD15259.1Acetolactate synthase, large subunit. (568 aa)
SMD18280.1Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
SMD18325.1Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (557 aa)
SMD19226.1FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase. (386 aa)
SMD20910.1Succinate dehydrogenase / fumarate reductase flavoprotein subunit. (574 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (607 aa)
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
SMD22519.1Malate dehydrogenase (oxaloacetate-decarboxylating). (460 aa)
SMD23106.14-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
SMD23107.1Malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase. (499 aa)
SMD23365.1Citrate synthase; Belongs to the citrate synthase family. (437 aa)
SMD24013.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (501 aa)
SMD24248.1Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (450 aa)
SMD24686.1Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (597 aa)
SMD25092.1Aconitate hydratase. (938 aa)
SMD25234.1Aconitase. (646 aa)
Your Current Organism:
Lentzea albidocapillata
NCBI taxonomy Id: 40571
Other names: ATCC 51859, CCUG 48294, CIP 104842, DSM 44073, IFO 15855, IMMIB D-958, IMSNU 21253, JCM 9732, L. albidocapillata, Lentzea albidicapillata, NBRC 100372, NBRC 15855, NRRL B-24057, Saccharothrix albidicapillata, Saccharothrix albidocapillata
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