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| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (289 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (390 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (339 aa) |
| | SMD11269.1 | Hypothetical protein. (275 aa) |
| | SMD11313.1 | Hypothetical protein. (98 aa) |
| | SMD11528.1 | FR47-like protein. (247 aa) |
| | SMD11533.1 | Hypothetical protein. (81 aa) |
| | SMD11711.1 | Acetyltransferase (GNAT) family protein. (306 aa) |
| | SMD11845.1 | Type I phosphodiesterase / nucleotide pyrophosphatase. (486 aa) |
| | SMD11931.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (528 aa) |
| | SMD12181.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Belongs to the class-II DAHP synthase family. (406 aa) |
| | SMD12281.1 | Hypothetical protein. (454 aa) |
| | glyA-2 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (421 aa) |
| | SMD12538.1 | Acetyltransferase (GNAT) family protein. (340 aa) |
| | SMD12634.1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (441 aa) |
| | SMD12668.1 | Glutamate synthase (NADPH/NADH) small chain. (494 aa) |
| | SMD12670.1 | Glutamate synthase (NADPH/NADH) large chain. (1507 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (262 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (269 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (512 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (116 aa) |
| | hisF | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (243 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | SMD12823.1 | Transketolase. (297 aa) |
| | SMD12831.1 | Transketolase. (210 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa) |
| | SMD14115.1 | GntR family transcriptional regulator. (255 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa) |
| | SMD14718.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Belongs to the class-II DAHP synthase family. (465 aa) |
| | pfp | 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (346 aa) |
| | SMD14847.1 | Asparagine synthase (glutamine-hydrolysing). (642 aa) |
| | SMD14882.1 | Branched-chain amino acid aminotransferase. (363 aa) |
| | SMD15256.1 | Acetolactate synthase, small subunit. (88 aa) |
| | SMD15259.1 | Acetolactate synthase, large subunit. (568 aa) |
| | SMD15954.1 | Hypothetical protein. (262 aa) |
| | SMD15958.1 | Acetyltransferase (GNAT) domain-containing protein. (265 aa) |
| | SMD17135.1 | TfoX N-terminal domain-containing protein. (109 aa) |
| | SMD17247.1 | Putative hydrolase. (328 aa) |
| | SMD17253.1 | Phosphotransferase enzyme family protein. (265 aa) |
| | SMD17266.1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (301 aa) |
| | SMD17278.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (537 aa) |
| | SMD18325.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (557 aa) |
| | SMD18420.1 | Diaminobutyrate-2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | SMD19077.1 | Hypothetical protein. (137 aa) |
| | SMD19287.1 | Hippurate hydrolase. (396 aa) |
| | SMD19722.1 | Phosphoserine phosphatase. (404 aa) |
| | SMD19725.1 | Thiamine kinase. (252 aa) |
| | SMD19986.1 | Hypothetical protein. (377 aa) |
| | SMD19995.1 | Predicted acetyltransferase, GNAT superfamily. (244 aa) |
| | SMD20061.1 | Glutamine synthetase. (474 aa) |
| | SMD20093.1 | Predicted acetyltransferase, GNAT family. (269 aa) |
| | SMD20095.1 | Predicted acetyltransferase, GNAT family. (275 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (400 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (369 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (399 aa) |
| | SMD20428.1 | GntR family transcriptional regulator. (251 aa) |
| | SMD20439.1 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (271 aa) |
| | SMD20495.1 | Glutamine synthetase. (449 aa) |
| | SMD20546.1 | Hypothetical protein. (299 aa) |
| | SMD20583.1 | Asparagine synthase (glutamine-hydrolysing). (607 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (411 aa) |
| | SMD20836.1 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (311 aa) |
| | SMD20867.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (183 aa) |
| | trpF-2 | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (201 aa) |
| | SMD20961.1 | Nucleoside phosphorylase. (294 aa) |
| | SMD21004.1 | Aromatic prenyltransferase, DMATS type. (364 aa) |
| | SMD21295.1 | HAD-superfamily subfamily IB hydrolase, TIGR01490. (264 aa) |
| | SMD21303.1 | Transcriptional regulator, RpiR family. (306 aa) |
| | SMD21305.1 | Nitric oxide dioxygenase; Belongs to the globin family. (372 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (354 aa) |
| | SMD21358.1 | Aspartate kinase; Belongs to the aspartokinase family. (421 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (607 aa) |
| | SMD21388.1 | Hippurate hydrolase. (401 aa) |
| | SMD21389.1 | Prephenate dehydrogenase. (316 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (355 aa) |
| | SMD21508.1 | Prephenate dehydratase. (278 aa) |
| | SMD21922.1 | Glutamine synthetase. (447 aa) |
| | SMD22001.1 | Threonine synthase. (378 aa) |
| | SMD22045.1 | L-threonine O-3-phosphate decarboxylase. (331 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (286 aa) |
| | SMC97544.1 | Histidinol-phosphatase. (246 aa) |
| | SMC97075.1 | Fructose-bisphosphate aldolase, class II. (273 aa) |
| | SMC95237.1 | Acetyltransferase (GNAT) family protein. (160 aa) |
| | SMC92779.1 | Tat (twin-arginine translocation) pathway signal sequence. (531 aa) |
| | SMC91382.1 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (565 aa) |
| | SMC90562.1 | Methyltransferase domain-containing protein. (243 aa) |
| | SMC90426.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1191 aa) |
| | SMC90396.1 | Phosphotransferase enzyme family protein. (312 aa) |
| | SMC90065.1 | GntR family transcriptional regulator. (223 aa) |
| | SMC89424.1 | Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase. (390 aa) |
| | SMC89360.1 | Lipopolysaccharide kinase (Kdo/WaaP) family protein. (248 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | SMC89176.1 | Tat (twin-arginine translocation) pathway signal sequence. (544 aa) |
| | SMC88955.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase. (339 aa) |
| | SMC88924.1 | Capreomycidine synthase. (367 aa) |
| | SMC88176.1 | Citrate synthase. (373 aa) |
| | SMC88173.1 | Citrate synthase; Belongs to the citrate synthase family. (369 aa) |
| | SMC85742.1 | Hypothetical protein. (290 aa) |
| | SMC85671.1 | Transposase. (151 aa) |
| | SMC85539.1 | Hypothetical protein. (134 aa) |
| | SMC85435.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (441 aa) |
| | SMC84960.1 | Probable phosphomutase, MSMEG_4193 family. (230 aa) |
| | SMC84932.1 | L-threonine aldolase. (311 aa) |
| | SMC84111.1 | Acetylornithine deacetylase. (423 aa) |
| | SMC83993.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (428 aa) |
| | SMC81914.1 | Threonine dehydratase. (318 aa) |
| | SMC80354.1 | Cystathione beta-lyase. (370 aa) |
| | SMC79288.1 | GntR family transcriptional regulator. (253 aa) |
| | SMC78110.1 | Citrate synthase. (253 aa) |
| | SMC77334.1 | Predicted acetyltransferase, GNAT superfamily. (266 aa) |
| | SMC76700.1 | Diaminopropionate ammonia-lyase. (335 aa) |
| | SMC76690.1 | Acetylornithine deacetylase. (373 aa) |
| | SMC69737.1 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa) |
| | SMC68880.1 | GntR family transcriptional regulator. (254 aa) |
| | SMC68796.1 | Histidinol-phosphatase. (259 aa) |
| | SMC68653.1 | Septum formation protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (199 aa) |
| | SMC68024.1 | GntR family transcriptional regulator. (247 aa) |
| | SMC67687.1 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (407 aa) |
| | SMC67659.1 | Predicted metal-dependent phosphoesterase TrpH, contains PHP domain. (502 aa) |
| | SMC67636.1 | Ribose-phosphate pyrophosphokinase. (314 aa) |
| | SMC67186.1 | Chorismate mutase. (86 aa) |
| | SMC65356.1 | Cysteine synthase A. (347 aa) |
| | rex | Redox-sensing transcriptional repressor; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (251 aa) |
| | SMC59916.1 | UPF0716 protein FxsA. (154 aa) |
| | SMC59498.1 | Acetyltransferase (GNAT) family protein. (238 aa) |
| | SMD25365.1 | Cystathionine gamma-synthase. (388 aa) |
| | SMD25363.1 | Cystathionine beta-synthase. (456 aa) |
| | pqqC | Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (231 aa) |
| | SMD25234.1 | Aconitase. (646 aa) |
| | SMD25092.1 | Aconitate hydratase. (938 aa) |
| | SMD25084.1 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | SMD25082.1 | Hypothetical protein. (73 aa) |
| | SMD24869.1 | Chorismate mutase. (120 aa) |
| | vapC-2 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (135 aa) |
| | SMD24257.1 | Acetyltransferase (GNAT) family protein. (211 aa) |
| | SMD24241.1 | Ribose 5-phosphate isomerase B. (154 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (375 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa) |
| | SMD24116.1 | Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (201 aa) |
| | SMD24110.1 | Threonine synthase. (418 aa) |
| | SMD22174.1 | TIGR02569 family protein. (265 aa) |
| | SMD22266.1 | Succinyldiaminopimelate desuccinylase. (355 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (320 aa) |
| | SMD22270.1 | Succinyldiaminopimelate aminotransferase apoenzyme. (365 aa) |
| | SMD22272.1 | Acetyltransferase (GNAT) family protein. (213 aa) |
| | SMD22323.1 | GntR family transcriptional regulator. (216 aa) |
| | SMD22334.1 | Ribosomal protein S18 acetylase RimI. (290 aa) |
| | SMD22370.1 | Asparagine synthase (glutamine-hydrolysing). (644 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (375 aa) |
| | SMD22549.1 | GntR family transcriptional regulator. (255 aa) |
| | SMD22686.1 | Threonine dehydratase. (309 aa) |
| | SMD22687.1 | Threonine dehydratase. (302 aa) |
| | SMD22689.1 | Transcriptional regulator, GntR family. (261 aa) |
| | dapA-2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (285 aa) |
| | SMD23079.1 | Glutamine synthetase. (446 aa) |
| | SMD23080.1 | Putative glutamine amidotransferase. (231 aa) |
| | SMD23160.1 | Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (262 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (375 aa) |
| | SMD23179.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (694 aa) |
| | SMD23365.1 | Citrate synthase; Belongs to the citrate synthase family. (437 aa) |
| | SMD23386.1 | Acetyltransferase (GNAT) family protein. (237 aa) |
| | SMD23628.1 | Broad specificity phosphatase PhoE; Belongs to the phosphoglycerate mutase family. (215 aa) |
| | rsmA | 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (278 aa) |
| | prs-2 | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | SMD23757.1 | Cystathione beta-lyase. (364 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (428 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (472 aa) |
| | SMD23959.1 | Homoserine dehydrogenase. (430 aa) |
| | SMD23960.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (357 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (284 aa) |
| | SMD24024.1 | Histidine phosphatase superfamily (branch 1). (139 aa) |
| | SMC58692.1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (567 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (493 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (436 aa) |
| | SMC54730.1 | Capreomycidine synthase. (372 aa) |
| | SMC54635.1 | Serine O-acetyltransferase. (213 aa) |
| | SMC53315.1 | Protein of unknown function. (382 aa) |
| | SMC50694.1 | Indole-3-glycerol phosphate synthase. (228 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (217 aa) |
| | SMC50668.1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (457 aa) |
| | SMC50600.1 | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | SMC50584.1 | Anthranilate phosphoribosyltransferase. (332 aa) |
| | SMC50000.1 | Asparagine synthase (glutamine-hydrolysing). (608 aa) |
| | SMC48600.1 | Hypothetical protein. (293 aa) |
| | SMC48507.1 | Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa) |
| | SMC48420.1 | Hypothetical protein. (293 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | SMC99104.1 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1179 aa) |
| | SMD01711.1 | Threonine dehydratase. (283 aa) |
| | SMD01760.1 | Cobalamin-independent synthase, Catalytic domain. (349 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (614 aa) |
| | SMD02064.1 | Acetolactate synthase, large subunit. (578 aa) |
| | SMD02066.1 | Acetolactate synthase, small subunit. (168 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | SMD02099.1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (529 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (345 aa) |
| | SMD02140.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (468 aa) |
| | leuD | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa) |
| | SMD02250.1 | Cystathionine gamma-lyase. (355 aa) |
| | SMD02324.1 | L-amino acid N-acyltransferase YncA. (136 aa) |
| | SMD02462.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa) |
| | SMD02495.1 | Ribosomal protein S18 acetylase RimI. (148 aa) |
| | SMD03435.1 | Hypothetical protein. (283 aa) |
| | SMD03714.1 | L-threonine aldolase. (321 aa) |
| | SMD03877.1 | Mycothiol synthase. (318 aa) |
| | SMD03915.1 | Maltose O-acetyltransferase. (185 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (298 aa) |
| | SMD04333.1 | Amino-acid N-acetyltransferase. (149 aa) |
| | SMD04417.1 | L-glutamine synthetase. (436 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | SMD06284.1 | Succinyldiaminopimelate aminotransferase apoenzyme. (367 aa) |
| | SMD07026.1 | Hypothetical protein. (301 aa) |
| | SMD07578.1 | L-threonine aldolase. (330 aa) |
| | SMD07598.1 | Aspartate/methionine/tyrosine aminotransferase. (376 aa) |
| | SMD07805.1 | Uncharacterized membrane protein YgaE, UPF0421/DUF939 family. (353 aa) |
| | SMD07851.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (344 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (405 aa) |
| | argH | Argininosuccinate lyase. (463 aa) |
| | SMD10890.1 | Argininosuccinate synthase. (88 aa) |
| | SMD10894.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (310 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (377 aa) |
