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eryAI eryAI eryAII eryAII eryAIII eryAIII SACE_0729 SACE_0729 eryF eryF pks16 pks16 SACE_1305 SACE_1305 pks1-3 pks1-3 SACE_2595 SACE_2595 SACE_2618 SACE_2618 SACE_2619 SACE_2619 SACE_2620 SACE_2620 SACE_2629 SACE_2629 SACE_2630 SACE_2630 SACE_2692 SACE_2692 SACE_2693 SACE_2693 dhbE dhbE SACE_2695 SACE_2695 SACE_2696 SACE_2696 SACE_2875 SACE_2875 SACE_3033 SACE_3033 SACE_3035 SACE_3035 SACE_3036 SACE_3036 SACE_3224 SACE_3224 SACE_3258 SACE_3258 dhbB dhbB dhbE-2 dhbE-2 dhbC dhbC dhbA, dhbA, SACE_4124 SACE_4124 SACE_4138 SACE_4138 SACE_4139 SACE_4139 SACE_4140 SACE_4140 SACE_4275 SACE_4275 SACE_4279 SACE_4279 SACE_4284 SACE_4284 SACE_4285 SACE_4285 SACE_4286 SACE_4286 SACE_4287 SACE_4287 SACE_4288 SACE_4288 SACE_4304 SACE_4304 pteA1 pteA1 SACE_4476 SACE_4476 pteA1-2 pteA1-2 SACE_4923 SACE_4923 chlB1 chlB1 SACE_5532 SACE_5532
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eryAIEryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. (3545 aa)
eryAIIEryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. (3567 aa)
eryAIIIEryAIII Erythromycin polyketide synthase modules 5 and 6. (3171 aa)
SACE_0729Thioesterase, erythromycin biosynthesis. (247 aa)
eryF6-deoxyerythronolide B hydroxylase (6-DEB hydroxylase); Catalyzes the conversion of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) by the insertion of an oxygen at the 6S position of 6-DEB. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase. (404 aa)
pks16acyl-CoA synthase. (511 aa)
SACE_1305Putative non-ribosomal peptide synthetase. (1767 aa)
pks1-3Modular polyketide synthase. (2208 aa)
SACE_2595Polyketide synthase type I. (2368 aa)
SACE_2618Amino acid adenylation. (320 aa)
SACE_2619Non-ribosomal peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (1048 aa)
SACE_2620Modular polyketide synthase; Similar to StiA and MxaF proteins from Stigmatella aurantiaca. (1522 aa)
SACE_2629Modular ype I polyketide synthase. (2117 aa)
SACE_2630Modular polyketide synthase. (4576 aa)
SACE_2692MbtH-like protein. (78 aa)
SACE_2693Non-ribosomal peptide synthase. (1167 aa)
dhbE2,3-dihydroxybenzoate-AMP ligase. (554 aa)
SACE_2695Putative non-ribosomal peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family. (1583 aa)
SACE_2696Putative non-ribosomal peptide synthetase. (2385 aa)
SACE_2875Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. (4132 aa)
SACE_3033Putative peptide monooxygenase. (441 aa)
SACE_3035Putative non-ribosomal peptide synthetase. (5429 aa)
SACE_3036MbtH protein. (67 aa)
SACE_3224Non-ribosomal peptide synthetase modules. (1315 aa)
SACE_3258Thioesterase involved in non-ribosomal peptide biosynthesis. (230 aa)
dhbBIsochorismatase (2,3 dihydro-2,3 dihydroxybenzoate synthase). (132 aa)
dhbE-22,3-dihydroxybenzoate-AMP ligase. (541 aa)
dhbCIsochorismate synthase. (421 aa)
dhbA,2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. (260 aa)
SACE_4124Non-ribosomal peptide synthetase. (363 aa)
SACE_4138Type I PKS modular polyketide synthas. (1806 aa)
SACE_4139Type I modular polyketide synthase. (5359 aa)
SACE_4140Type I modular polyketide synthase. (3481 aa)
SACE_4275Thioesterase involved in non-ribosomal peptide biosynthesis. (235 aa)
SACE_4279Non-ribosomal peptide synthetase/polyketide synthase; Belongs to the ATP-dependent AMP-binding enzyme family. (1069 aa)
SACE_4284MbtH-like protein. (72 aa)
SACE_4285AMP-dependent synthetase and ligase. (1260 aa)
SACE_4286Thioesterase. (270 aa)
SACE_4287Putative non-ribosomal peptide synthetase. (3337 aa)
SACE_4288Putative non-ribosomal peptide synthetase. (7259 aa)
SACE_4304Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. (577 aa)
pteA1Modular polyketide synthase. (1438 aa)
SACE_4476Multi-domain beta-ketoacyl synthase. (1568 aa)
pteA1-2Modular polyketide synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (571 aa)
SACE_4923Hypothetical protein; Non-ribosomal peptide synthetase modules. (532 aa)
chlB1Iterative type I polyketide synthase. (1730 aa)
SACE_5532Iterative type I polyketide synthase. (1738 aa)
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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