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wblA wblA nth nth mutY mutY thiC thiC moaA moaA udgB udgB ispH-2 ispH-2 SACE_1010 SACE_1010 whiB whiB SACE_1383 SACE_1383 cysH cysH nirA nirA SACE_1477 SACE_1477 lipA lipA miaB miaB fumB fumB SACE_1790 SACE_1790 SACE_2037 SACE_2037 SACE_2432 SACE_2432 SACE_2433 SACE_2433 whiB1 whiB1 SACE_3061 SACE_3061 SACE_3561 SACE_3561 SACE_3562 SACE_3562 acnA1 acnA1 SACE_3800 SACE_3800 acn acn narG narG SACE_4073 SACE_4073 SACE_4189 SACE_4189 SACE_4190 SACE_4190 acnA, acnA, fprB fprB sdaA sdaA SACE_4509 SACE_4509 SACE_4563 SACE_4563 bioB bioB SACE_4912 SACE_4912 whiB3 whiB3 nadA nadA rimO rimO ispG ispG rlmN rlmN leuC leuC sdaA-2 sdaA-2 whiB1-2 whiB1-2 whiB2 whiB2 SACE_6594 SACE_6594 nuoI nuoI nuoG nuoG nuoF nuoF nuoB nuoB purF purF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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wblATranscriptional regulator. (79 aa)
nthPutative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (245 aa)
mutYA/G-specific adenine glycosylase. (302 aa)
thiCPutative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (547 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (349 aa)
udgBuracil-DNA glycosylase. (256 aa)
ispH-24-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (342 aa)
SACE_10104Fe-4S ferredoxin, iron-sulfur binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
whiBWhiB-family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (129 aa)
SACE_1383Oxidoreductase alpha (molybdopterin) subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (772 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (241 aa)
nirAFerredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (570 aa)
SACE_1477Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (409 aa)
lipAPutative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (323 aa)
miaBMethylase of isopentenylated A37 derivatives in tRNA; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (491 aa)
fumBFumarate hydratase class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
SACE_1790HhH-GPD. (190 aa)
SACE_2037Radical SAM domain protein. (371 aa)
SACE_2432Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (889 aa)
SACE_2433NADH-quinone oxidoreductase chain F. (559 aa)
whiB1Putative transcriptional regulator (WhiB family); Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
SACE_3061NADH ubiquinone oxidoreductase, 20 kDa subunit. (346 aa)
SACE_3561Molybdopterin oxidoreductase Fe4s4 region. (205 aa)
SACE_3562Formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (876 aa)
acnA1Aconitate hydratase. (644 aa)
SACE_3800Assimilatory nitrate reductase catalytic subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (689 aa)
acnAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (937 aa)
narGNitrate reductase alpha chain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1172 aa)
SACE_4073Indolepyruvate ferredoxin oxidoreductase alpha and beta subunit. (1159 aa)
SACE_4189Putative DNA polymerase related protein. (82 aa)
SACE_4190DNA polymerase bacteriophage-type. (197 aa)
acnA,Aconitate hydratase 1. (711 aa)
fprBferredoxin--NADP+ reductase. (508 aa)
sdaAL-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (453 aa)
SACE_4509Oxidoreductase alpha (molybdopterin) subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (760 aa)
SACE_4563Hypothetical protein; Coproporphyrinogen III oxidase. (515 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (355 aa)
SACE_4912Assimilatory nitrate reductase catalytic subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (608 aa)
whiB3Putative transcriptional regulator (WhiB family); Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (94 aa)
nadAQuinolinate synthetase A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (345 aa)
rimOHypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (484 aa)
ispG1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
rlmNPredicted Fe-S-cluster redox enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (369 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
sdaA-2L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (451 aa)
whiB1-2Putative transcriptional regulator (WhiB family); Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
whiB2Putative transcriptional regulator (WhiB family); Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (95 aa)
SACE_6594Hypothetical protein; Thiamine biosynthesis enzyme ThiH. (866 aa)
nuoINADH dehydrogenase (quinone); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (188 aa)
nuoGNADH dehydrogenase I chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (837 aa)
nuoFNADH dehydrogenase I chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (431 aa)
nuoBNADH dehydrogenase I chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (220 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (538 aa)
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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