STRINGSTRING
SACE_4140 SACE_4140 SACE_2968 SACE_2968 SACE_2875 SACE_2875 SACE_2742 SACE_2742 fadA6 fadA6 SACE_2630 SACE_2630 SACE_2629 SACE_2629 SACE_2620 SACE_2620 SACE_2595 SACE_2595 pks1-2 pks1-2 pks1-3 pks1-3 SACE_1824 SACE_1824 fabH fabH fabF-2 fabF-2 rppA rppA mmgA mmgA fadA3 fadA3 eryAIII eryAIII eryAII eryAII eryAI eryAI fabF fabF SACE_0023 SACE_0023 SACE_0021 SACE_0021 fabH-2 fabH-2 SACE_5946 SACE_5946 fadA4 fadA4 fadA-2 fadA-2 SACE_7304 SACE_7304 fabH5-2 fabH5-2 fabF-3 fabF-3 SACE_5532 SACE_5532 chlB1 chlB1 chlB3 chlB3 pksF pksF pteA1-2 pteA1-2 pksG pksG SACE_4475 SACE_4475 pteA1 pteA1 SACE_4141 SACE_4141 SACE_4139 SACE_4139 SACE_4138 SACE_4138 SACE_4133 SACE_4133 catF catF fadA fadA fabH5 fabH5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SACE_4140Type I modular polyketide synthase. (3481 aa)
SACE_2968Putative 3-oxoacyl-ACP synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (385 aa)
SACE_2875Modular polyketide synthase-; Modular PKS with 1 AHBA loading domain similar to GdmAI, and two extension modules, first module has complete set of the reductive domains, and the other one didn't have any reductive domains. Found by M.Oliynyk and sequenced by M.Samborskyy (M0ERY) in 2004/02. If it is active, than it can be responsible for the production of the aromatic poliketide antibiotic with low molecular weight. Thanks to the B. Ostash, A. Luzhetsky and Y. Rebets for help with annotation of this cluster in 2004. (4132 aa)
SACE_2742Putative lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family. (380 aa)
fadA6acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
SACE_2630Modular polyketide synthase. (4576 aa)
SACE_2629Modular ype I polyketide synthase. (2117 aa)
SACE_2620Modular polyketide synthase; Similar to StiA and MxaF proteins from Stigmatella aurantiaca. (1522 aa)
SACE_2595Polyketide synthase type I. (2368 aa)
pks1-2Modular polyketide synthase; Contains putative Sfp-type phosphopantetheinyl transferase domain; Belongs to the P-Pant transferase superfamily. (1442 aa)
pks1-3Modular polyketide synthase. (2208 aa)
SACE_1824Acetyl-coa acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (415 aa)
fabH3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (327 aa)
fabF-23-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (414 aa)
rppAPutative type III polyketide synthase. (367 aa)
mmgAacetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (479 aa)
fadA3acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
eryAIIIEryAIII Erythromycin polyketide synthase modules 5 and 6. (3171 aa)
eryAIIEryAII Erythromycin polyketide synthase modules 3 and 4; DEBS2. (3567 aa)
eryAIEryAI Erythromycin polyketide synthase modules 1 and 2; DEBS1. (3545 aa)
fabF3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (382 aa)
SACE_0023Beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (2322 aa)
SACE_0021Putative multi-domain beta-ketoacyl synthase. (1314 aa)
fabH-23-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (327 aa)
SACE_5946Putative 3-oxoacyl-ACP synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (382 aa)
fadA4acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
fadA-2Acetyl CoA acetyltransferase (thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
SACE_7304acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
fabH5-23-oxoacyl-ACP synthase III. (337 aa)
fabF-33-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (407 aa)
SACE_5532Iterative type I polyketide synthase. (1738 aa)
chlB1Iterative type I polyketide synthase. (1730 aa)
chlB33-oxoacyl-ACP synthase III. (345 aa)
pksFbeta-ketoacyl-ACP synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (414 aa)
pteA1-2Modular polyketide synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (571 aa)
pksGhydroxymethylglutaryl-CoA synthase. (407 aa)
SACE_4475Multi-domain beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (922 aa)
pteA1Modular polyketide synthase. (1438 aa)
SACE_4141Type I modular polyketide synthase. (4327 aa)
SACE_4139Type I modular polyketide synthase. (5359 aa)
SACE_4138Type I PKS modular polyketide synthas. (1806 aa)
SACE_4133ketoacyl-ACP synthase (typeII); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa)
catFacetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
fadA3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (375 aa)
fabH53-oxoacyl-ACP synthase III. (330 aa)
Your Current Organism:
Saccharopolyspora erythraea
NCBI taxonomy Id: 405948
Other names: S. erythraea NRRL 2338, Saccharopolyspora erythraea ATCC 11635, Saccharopolyspora erythraea DSM 40517, Saccharopolyspora erythraea JCM 4748, Saccharopolyspora erythraea NRRL 2338, Saccharopolyspora erythraea str. NRRL 2338, Saccharopolyspora erythraea strain NRRL 2338
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