STRINGSTRING
topA topA ABR54176.1 ABR54176.1 lig lig top6B top6B ABR54257.1 ABR54257.1 ABR54264.1 ABR54264.1 endA endA radA radA dnaG dnaG fen fen mre11 mre11 rad50 rad50 rnhB rnhB ABR54612.1 ABR54612.1 top6A top6A pcn pcn ABR54930.1 ABR54930.1 priS priS ABR55027.1 ABR55027.1 priL priL polB polB rfcL rfcL hjc hjc ABR55264.1 ABR55264.1 rfcS rfcS radB radB ABR55451.1 ABR55451.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (817 aa)
ABR54176.1MCM family protein; PFAM: magnesium chelatase ChlI subunit; MCM family protein; KEGG: mmp:MMP0030 DNA replication protein; MCM family; putative; Belongs to the MCM family. (607 aa)
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (573 aa)
top6BDNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (666 aa)
ABR54257.1MCM family protein; PFAM: magnesium chelatase ChlI subunit; MCM family protein; ATPase associated with various cellular activities AAA_5; KEGG: mmp:MMP1024 MCM family related protein; Belongs to the MCM family. (710 aa)
ABR54264.1PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mmp:MMP1032 replication protein A. (641 aa)
endAtRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (177 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (322 aa)
dnaGTOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (443 aa)
fenXPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...] (324 aa)
mre11Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (375 aa)
rad50SMC domain protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (1019 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (244 aa)
ABR54612.1ERCC4 domain protein; PFAM: helix-hairpin-helix motif; helicase domain protein; ERCC4 domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: Helix-hairpin-helix DNA-binding class 1; DEAD-like helicases; KEGG: mmp:MMP1395 helix-hairpin-helix motif:DEAD/DEAH box helicase:helicase, C-terminal:helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. (776 aa)
top6ADNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (365 aa)
pcnProliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (249 aa)
ABR54930.1MCM family protein; PFAM: magnesium chelatase ChlI subunit; MCM family protein; KEGG: mmp:MMP0030 DNA replication protein; MCM family; putative; Belongs to the MCM family. (672 aa)
priSPutative DNA primase, small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer s [...] (355 aa)
ABR55027.1KEGG: mmp:MMP0122 hypothetical protein. (298 aa)
priLDNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (369 aa)
polBDNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (594 aa)
rfcLAAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (492 aa)
hjcResolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (132 aa)
ABR55264.1TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B; KEGG: mmp:MMP0380 DNA polymerase family B. (810 aa)
rfcSReplication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (315 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (213 aa)
ABR55451.1KEGG: mmp:MMP0638 hypothetical protein. (741 aa)
Your Current Organism:
Methanococcus vannielii
NCBI taxonomy Id: 406327
Other names: M. vannielii SB, Methanococcus vannielii SB, Methanococcus vannielii str. SB, Methanococcus vannielii strain SB
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