node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
XNC1_2290 | XNC1_3112 | XNC1_2290 | XNC1_3112 | Putative amidotransferase. | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.906 |
XNC1_2290 | apt | XNC1_2290 | XNC1_0954 | Putative amidotransferase. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.924 |
XNC1_2290 | gpt | XNC1_2290 | XNC1_1252 | Putative amidotransferase. | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.924 |
XNC1_2290 | gsk | XNC1_2290 | XNC1_0945 | Putative amidotransferase. | Inosine-guanosine kinase. | 0.901 |
XNC1_2290 | guaA | XNC1_2290 | XNC1_1954 | Putative amidotransferase. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.913 |
XNC1_2290 | guaB | XNC1_2290 | XNC1_1955 | Putative amidotransferase. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.964 |
XNC1_2290 | hpt | XNC1_2290 | XNC1_0911 | Putative amidotransferase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.920 |
XNC1_2290 | ushA | XNC1_2290 | XNC1_0942 | Putative amidotransferase. | Bifunctional: UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.901 |
XNC1_2806 | cdd | XNC1_2806 | XNC1_1493 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Cytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.900 |
XNC1_2806 | deoA | XNC1_2806 | XNC1_3807 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.900 |
XNC1_2806 | deoD | XNC1_2806 | XNC1_3804 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Purine-nucleoside phosphorylase. | 0.903 |
XNC1_2806 | udp | XNC1_2806 | XNC1_3889 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. | 0.900 |
XNC1_2806 | ushA | XNC1_2806 | XNC1_0942 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. | Bifunctional: UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.906 |
XNC1_3112 | XNC1_2290 | XNC1_3112 | XNC1_2290 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative amidotransferase. | 0.906 |
XNC1_3112 | gpt | XNC1_3112 | XNC1_1252 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.914 |
XNC1_3112 | guaA | XNC1_3112 | XNC1_1954 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. | 0.973 |
XNC1_3112 | guaB | XNC1_3112 | XNC1_1955 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
XNC1_3112 | hpt | XNC1_3112 | XNC1_0911 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.906 |
XNC1_3112 | ushA | XNC1_3112 | XNC1_0942 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Bifunctional: UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.900 |
add | apt | XNC1_2317 | XNC1_0954 | Adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.442 |