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| | metL | Bifunctional: aspartokinase II (N-terminal); homoserine dehydrogenase II (C-terminal), methionine sensitive. (811 aa) |
| | glmU | Bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (462 aa) |
| | atpC | Membrane-bound ATP synthase, F1 sector, epsilon-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa) |
| | atpD | Membrane-bound ATP synthase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa) |
| | atpG | Membrane-bound ATP synthase, F1 sector, gamma-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa) |
| | atpA | Membrane-bound ATP synthase, F1 sector, alpha-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | atpH | Membrane-bound ATP synthase, F1 sector, delta-subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa) |
| | atpF | Membrane-bound ATP synthase, F0 sector, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpE | Membrane-bound ATP synthase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (78 aa) |
| | atpB | Membrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (274 aa) |
| | rbsK | D-ribose transport protein (ABC superfamily, peri_bind) (C-terminal fragment); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (314 aa) |
| | acs | acetyl-CoA synthetase, has propionyl-CoA synthetase activity; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compo [...] (651 aa) |
| | rpe | D-ribulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (173 aa) |
| | fdhD | Formate dehydrogenase formation protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (276 aa) |
| | yegV | Putative sugar kinase with ribokinase-like domain. (297 aa) |
| | pfkA | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa) |
| | cpxA | Two-component system, OmpR family, sensor histidine kinase CpxA; Function experimentally demonstrated in the studied strain; regulator. (460 aa) |
| | XNC1_0114 | Aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the DegT/DnrJ/EryC1 family. (361 aa) |
| | XNC1_0133 | Transferase hexapeptide repeat. (291 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa) |
| | coaD | CMP-deoxy-D-manno-octulosonate-lipid A transferase (phosphopantetheine adenylyltransferase); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | dfp | Bifunctional: 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (409 aa) |
| | dut | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (507 aa) |
| | XNC1_0241 | Putative Phosphoglycolate phosphatase. (231 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa) |
| | coaA | Pantothenate kinase. (316 aa) |
| | gpp | Guanosine pentaphosphatase, also has exopolyphosphatase activity; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (503 aa) |
| | cyaA | Adenylate cyclase; Belongs to the adenylyl cyclase class-1 family. (840 aa) |
| | yigB | Putative enzyme with a phosphatase-like domain. (238 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (322 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | cysQ | Protein that acts on 3'-phosphoadenosine-5'-phosphosulfate with sugar phosphatase domain; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (247 aa) |
| | ppa | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. (176 aa) |
| | yehU | Putative sensory kinase in two-component regulatory system. (559 aa) |
| | nrdG | Anaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (154 aa) |
| | pyrI | Aspartate carbamoyltransferase, regulatory subunit (allosteric regulation); Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa) |
| | XNC1_0577 | Hypothetical protein. (113 aa) |
| | thiG | Thiamin biosynthesis enzyme subunit, with ThiH; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (255 aa) |
| | thiS | C-terminally thiocarboxylated form is intermediate sulfur donor in thiazole formation; part of ThiF/ThiS complex; complexes with ThiG also. (66 aa) |
| | thiF | Adenylation of ThiS; with ThiI, thiolation of ThiS; in thiazole synthesis. (259 aa) |
| | thiE | Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (224 aa) |
| | thiC | 5'-phosphoryl-5-aminoimidazole = 4-amino-5-hydroxymethyl-2-methylpyrimidine-P; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (663 aa) |
| | XNC1_0591 | Conserved hypothetical protein. (61 aa) |
| | XNC1_0614 | Putative hydrolase, haloacid dehalogenase-like family. (220 aa) |
| | nudC | NADH pyrophosphatase; Belongs to the Nudix hydrolase family. NudC subfamily. (257 aa) |
| | purD | Phosphoribosylglycinamide synthetase (GAR synthetase); Belongs to the GARS family. (427 aa) |
| | purH | Bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal). (529 aa) |
| | garK | Glycerate kinase I; Belongs to the glycerate kinase type-1 family. (377 aa) |
| | nadR | Transcriptional regulator of NAD biosynthesis; regulator of PnuC activity; NMN adenylyltransferase. (408 aa) |
| | XNC1_0686 | Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (177 aa) |
| | ytjC | Putative phosphoglyceromutase 2; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa) |
| | thrA | Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal), threonine sensitive. (824 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (316 aa) |
| | XNC1_0697 | Hypothetical protein. (201 aa) |
| | talB | Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (317 aa) |
| | mog | Putative molybdochetalase in molybdopterine biosynthesis, metal incorporation step. (191 aa) |
| | XNC1_0741 | Metallophosphoesterase:5'-Nucleotidase, C-terminal precursor (fragment). (67 aa) |
| | XNC1_0742 | Putative 5`-nucleotidase family protein precursor (fragment). (72 aa) |
| | phoR | Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Sensory histidine kinase in two-component regulatory system with PhoB, regulation of Pi uptake, senses Pi. (436 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (347 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (163 aa) |
| | XNC1_0787 | Putative Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (195 aa) |
| | accC | Acetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | XNC1_0881 | Protein mazG. (266 aa) |
| | relA | (p)ppGpp synthetase I (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (745 aa) |
| | XNC1_0884 | Sensor protein BarA. (773 aa) |
| | dgt | Deoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (508 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase. (159 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (188 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa) |
| | ushA | Bifunctional: UDP-sugar hydrolase; 5'-nucleotidase; Belongs to the 5'-nucleotidase family. (552 aa) |
| | gsk | Inosine-guanosine kinase. (436 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa) |
| | tesB | acyl-CoA thioesterase II. (284 aa) |
| | thiI | Sulfur transfer protein (from cys to ThiS and from IscS to U8-tRNA); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (482 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | XNC1_1004 | Similar to Biotin carboxylase; Function of strongly homologous gene; enzyme. (453 aa) |
| | lpxC | Tubulin-like GTP-binding protein and GTPase, forms circumferential ring in cell division (fragment); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (305 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa) |
| | aceE | Pyruvate dehydrogenase, decarboxylase subunit, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | aceF | Pyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (519 aa) |
| | rpiA | Ribosephosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa) |
| | XNC1_1125 | Putative O antigen biosynthesis protein (fragment); Gene remnant; enzyme. (201 aa) |
| | yeiC | Putative sugar kinase with ribokinase-like domain. (355 aa) |
| | XNC1_1145 | Conserved hypothetical protein. (287 aa) |
| | cobU | Bifunctional: cobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (182 aa) |
| | gpt | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (153 aa) |
| | proB | Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa) |
| | aroL | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | aas | Bifunctional: 2-acylglycerophospho-ethanolamine acyl transferase (N-terminal); Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family. (717 aa) |
| | XNC1_1260 | Conserved hypothetical protein; Belongs to the CinA family. (167 aa) |
| | pssA | Phosphatidylserine synthase (CDP-diacylglycerol-serine O-phosphatidyltransferase). (451 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase, NAD(P)-requiring; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (246 aa) |
| | ybeX | Putative integral membrane protein with CBS regulatory domain. (292 aa) |
| | nagC | Transcriptional repressor of genes for catabolic enzymes (NagC/XylR (ROK) family). (407 aa) |
| | nagE | PTS family enzyme IIC (N-terminal); enzyme IIB (center); enzyme IIA (C-terminal), N-acetylglucosamine-specific. (675 aa) |
| | kdpD | Sensory histidine kinase in two-component regulatory system wtih KdpE, regulation of potassium translocation. (904 aa) |
| | sucB | Dihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa) |
| | gpmA | Phosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | ybhA | Putative phosphatase. (271 aa) |
| | ybhE | Putative isomerase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. (328 aa) |
| | XNC1_1438 | Var1. (121 aa) |
| | XNC1_1448 | Molybdopterin biosynthesis protein A (fragment); Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (254 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (159 aa) |
| | moaD | Molybdenum cofactor biosynthesis protein D. (81 aa) |
| | moaE | Molybdopterin converting factor, subunit 2. (163 aa) |
| | moeB | ATP-dependent adenylate transferase, modifies MoaD. (251 aa) |
| | moeA | Molybdopterin biosynthesis protein, molybdenum incorporation step; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (412 aa) |
| | folE | GTP cyclohydrolase I. (222 aa) |
| | udk | Uridine/cytidine kinase. (213 aa) |
| | dcd | 2'-deoxycytidine 5'-triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa) |
| | gnd | Gluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | grxA | Glutaredoxin 1 redox coenzyme for glutathione-dependent ribonucleotide reductase. (89 aa) |
| | cmk | Cytidine monophosphate (CMP) kinase. (228 aa) |
| | lpxK | Tetraacyldisaccharide 4' kinase (lipid A 4'kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (331 aa) |
| | XNC1_1570 | Protein ycaR; Belongs to the UPF0434 family. (59 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (404 aa) |
| | pyrD | Dihydro-orotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa) |
| | cheA | Two-component system, chemotaxis family, sensor kinase CheA; Chemotactic sensory histidine kinase (soluble) in two-component regulatory system with CheB and CheY, senses chemotactic signal. (715 aa) |
| | pyrC | Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (350 aa) |
| | lpxL | Lauroyl transferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (313 aa) |
| | fliI | Flagellum-specific ATP synthase. (458 aa) |
| | XNC1_1758 | Putative Pyruvate dehydrogenase (acetyl-transferring). (664 aa) |
| | XNC1_1767 | Putative polyketide biosynthesis protein pksG. (411 aa) |
| | XNC1_1779 | Putative surface protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor. (359 aa) |
| | XNC1_1819 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the fructosamine kinase family. (287 aa) |
| | pgbP1 | UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (381 aa) |
| | pbgP2 | Putative sugar transferase with nucleotide-diphospho-sugar transferase domain; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (327 aa) |
| | pbgP3 | Putative formyltransferase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the N-terminal section; belongs to the Fmt family. UDP- L-Ara4N formyltransferase subfamily. (673 aa) |
| | pbgP4 | PbgP4 protein; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (297 aa) |
| | pbgE1 | 4-amino-4-deoxy-L-arabinose transferase (lipid A modification); Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (553 aa) |
| | pbgE2 | Inner membrane protein yfbW; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (116 aa) |
| | pbgE3 | Putative membrane protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (136 aa) |
| | XNC1_1860 | Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (287 aa) |
| | pps | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (797 aa) |
| | pykF | Pyruvate kinase I (formerly F), fructose-stimulated. (469 aa) |
| | purR | Transcriptional repressor for de novo purine nucleotide synthesis (GalR/LacI family); Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. (341 aa) |
| | anmK | Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (369 aa) |
| | pdxH | Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | pdxY | Pyridoxal kinase 2/pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (292 aa) |
| | XNC1_1907 | Predicted kinase from adenilate kinase family, FLAR-like protein. (198 aa) |
| | XNC1_1910 | Hypothetical protein. (44 aa) |
| | XNC1_1929 | Conserved hypothetical protein; Belongs to the Nudix hydrolase family. PCD1 subfamily. (189 aa) |
| | manX | PTS family enzyme IIA (N-terminal); enzyme IIB (C-terminal), mannose-specific. (316 aa) |
| | uhpB | Sensory histidine kinase in two-component regulatory sytem with UhpA, regulates uhptT expression. (507 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | IMP dehydrogeanse; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (517 aa) |
| | yeiC-2 | Putative sugar kinase with ribokinase-like domain. (362 aa) |
| | uspG | Universal stress protein UP12, flavoprotein, ETFP adenine nucleotide-binding domain; Function of strongly homologous gene; phenotype. (142 aa) |
| | uspF | Universal stress protein F; Function of strongly homologous gene; putative carrier. (145 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (291 aa) |
| | ychA | Putative transcriptional regulator with tetratricopeptide repeats (TPR) domain. (269 aa) |
| | XNC1_2118 | Putative Thiamine-phosphate kinase. (332 aa) |
| | lpxM | Myristoyl transferase in lipid A biosynthesis, suppressor of htrB (lpxL); Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. (322 aa) |
| | pykA | Pyruvate kinase II, glucose-stimulated; Belongs to the pyruvate kinase family. (480 aa) |
| | zwf | Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa) |
| | purA-2 | Adenylosuccinate synthetase 1 (IMP--aspartate ligase 1) (AdSS 1) (AMPSase 1); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (420 aa) |
| | XNC1_2292 | Ribitol kinase. (542 aa) |
| | XNC1_2298 | Transcriptional regulator, LysR family (fragment); Gene remnant; enzyme. (181 aa) |
| | add | Adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa) |
| | ydgK | Putative oxidoreductase. (146 aa) |
| | tccC-2 | C component of insecticidal toxin complex (Tc); Function of strongly homologous gene; phenotype. (969 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (241 aa) |
| | yciA | Putative enzyme with thioesterase/thiol ester dehydrase-isomerase domain. (144 aa) |
| | cls | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa) |
| | tdk | Deoxythymidine kinase; Function experimentally demonstrated in the studied strain; enzyme. (198 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (347 aa) |
| | pncA | Nicotinamidase/pyrazinamidase. (222 aa) |
| | xptB1 | C component of insecticidal toxin complex (Tc); Function of strongly homologous gene; phenotype. (1016 aa) |
| | pgsA | CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase; Phosphatidylglycerophosphate synthetase (CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyl transferase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase). (237 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase (AIR synthetase). (347 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa) |
| | ppk | Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (689 aa) |
| | fbaB | Fructose-bisphosphate aldolase class I. (349 aa) |
| | thiD | Bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase). (265 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | phoQ | Two-component system, OmpR family, sensor histidine kinase PhoQ; Function of homologous gene experimentally demonstrated in an other organism; regulator. (478 aa) |
| | thiK | Putative Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate. (285 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein, methyltransferase domain; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (340 aa) |
| | XNC1_2741 | Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (196 aa) |
| | fruK | Fructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. (312 aa) |
| | pta | Phosphotransacetylase (phosphate acetyltransferase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (688 aa) |
| | ackA | Acetate kinase A (propionate kinase 2); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | XNC1_2806 | Putative alpha helix protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (201 aa) |
| | XNC1_2833 | Conserved hypothetical protein. (416 aa) |
| | rcsD | Phosphotransferase RcsD; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (924 aa) |
| | rcsC | Sensor histidine kinase RcsC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (930 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase 1, beta subunit. (376 aa) |
| | XNC1_2932 | Conserved hypothetical protein. (1327 aa) |
| | gntK | Gluconate kinase 2 in GNT I system, thermoresistant. (178 aa) |
| | XNC1_2968 | Conserved hypothetical protein. (384 aa) |
| | XNC1_2981 | Putative Fructokinase. (635 aa) |
| | fbaA | A component of insecticidal toxin complex (Tc) (fragment); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (358 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (388 aa) |
| | epd | D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (339 aa) |
| | tktA | Transketolase 1 thiamin-binding, isozyme; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa) |
| | lpcA | D-sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (193 aa) |
| | XNC1_3046 | Conserved hypothetical protein. (162 aa) |
| | XNC1_3047 | Conserved hypothetical protein. (87 aa) |
| | XNC1_3104 | Conserved hypothetical protein; Belongs to the UPF0301 (AlgH) family. (187 aa) |
| | XNC1_3112 | Putative protein controls HAP (6-N-hydroxylaminopurine) mutagenesis (Ham1); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa) |
| | yeiU | Putative phosphatase; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (234 aa) |
| | yfcD | Putative enzyme (Nudix hydrolase). (170 aa) |
| | purF | Amidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa) |
| | accD | acetylCoA carboxylase, carboxyltranferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (315 aa) |
| | XNC1_3171 | Two-component sensor kinase. (477 aa) |
| | ptsI | PTS family enzyme I and Hpr components, PEP-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa) |
| | nadK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (299 aa) |
| | purL | Phosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa) |
| | yfhK | Putative sensory kinase in regulatory system. (547 aa) |
| | nadE | Putative glutamine-dependent NAD(+) synthetase (NAD(+) synthase [glutamine-hydrolyzing]) (NadE); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (540 aa) |
| | suhB | Inositol monophosphatase. (267 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (373 aa) |
| | folD | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa) |
| | XNC1_3486 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (421 aa) |
| | nodQ | Putative bifunctional enzyme: sulfate adenylyltransferase and Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (642 aa) |
| | XNC1_3495 | Hypothetical protein; No homology to any previously reported sequences. (181 aa) |
| | XNC1_3734 | Conserved hypothetical protein (Similar to photopexin A/B of Photorhabdus luminescens); Homologs of previously reported genes of unknown function. (74 aa) |
| | mak | Putative kinase/transcriptional regulator, actin-like ATPase domain (NagC/XylR (ROK) familiy). (301 aa) |
| | cpdB | 2':3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (652 aa) |
| | ribF | Bifunctional: flavokinase; FAD synthetase; Belongs to the ribF family. (314 aa) |
| | ispH | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. (317 aa) |
| | carA | Carbamoyl phosphate synthetase, glutamine amidotransferase small subunit; Belongs to the CarA family. (380 aa) |
| | carB | Carbamoyl phosphate synthase, large subunit; Belongs to the CarB family. (1074 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (407 aa) |
| | deoC | 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa) |
| | surE | Survival protein, protein damage control; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (254 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | ispD | 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (264 aa) |
| | cysC | Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate. (215 aa) |
| | ubiB | 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (545 aa) |
| | XNC1_3888 | Conserved hypothetical protein. (260 aa) |
| | udp | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (251 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (322 aa) |
| | XNC1_3911 | Hypothetical protein. (270 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (123 aa) |
| | plsB | Glycerolphosphate acyltransferase; Belongs to the GPAT/DAPAT family. (822 aa) |
| | pgi | Glucosephosphate isomerase; Belongs to the GPI family. (548 aa) |
| | lysC | Aspartokinase III, lysine sensitive; Belongs to the aspartokinase family. (457 aa) |
| | aceK | Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (593 aa) |
| | accA-2 | acetylCoA carboxylase, carboxytransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | lpxB | tetraacyldisaccharide-1-P synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (389 aa) |
| | lpxA | UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (265 aa) |
| | fabZ | (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (150 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell; Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (342 aa) |
| | cdsA | CDP-diglyceride synthase; Belongs to the CDS family. (287 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (398 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | thyA | Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | ptsP | PTS family enzyme I, transcriptional regulator (with NPR and NTR proteins); Belongs to the PEP-utilizing enzyme family. (748 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (333 aa) |
| | plsC | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (243 aa) |
| | nudF | Adenosine diphosphate sugar pyrophosphatase (ADP-ribose pyrophosphatase). (213 aa) |
| | rfaE | Putative bifunctional ADP-L-glycero-D-manno-heptose synthase: putaive kinase (N-terminal); Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa) |
| | ygiH | Putative membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (217 aa) |
| | arcB | Aerobic respiration control sensor protein; Hybrid sensory histidine kinase in two-component regulatory system with ArcA, regulates respiration and fermentation, senses oxidized quinones. (777 aa) |
| | hipA | hipA protein; Function of strongly homologous gene; regulator. (432 aa) |
| | XNC1_4239 | Putative phosphoribosylglycinamide formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (201 aa) |
| | XNC1_4242 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (185 aa) |
| | XNC1_4311 | DNA helicase related protein (fragment). (256 aa) |
| | ydeV | Putative sugar kinase, actin-like ATPase domain; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position. (530 aa) |
| | lsrF | Putative aldolase with ribulose-phoshate binding barrel; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (294 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis protein B, GTP-binding. (174 aa) |
| | mobA | Molybdopterin-guanine dinucleotide synthase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (200 aa) |
| | srkA | Protein rdoA; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (329 aa) |
| | prkB | Putative phosphoribulokinase with nucleoside triP hydrolase domain. (289 aa) |
| | yfeV | Putative PTS family enzyme IIBC with sucrose/glucose-specific domain. (488 aa) |
| | XNC1_4359 | Mono-phosphatase. (265 aa) |
| | glnL | Sensory kinase (soluble) in two-component regulatory system with GlnG, nitrogen regulation (nitrogen regulator II, NRII). (347 aa) |
| | XNC1_4435 | EnvZ. (342 aa) |
| | glpD | Sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic); Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (501 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa) |
| | spoT | Bifunctional: (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (704 aa) |
| | treB | PTS family enzyme IIBC, trehalose(maltose)-specific. (477 aa) |
| | nudE | ADP-ribose diphosphatase; Nudix hydrolase, active on adenosine(5')triphospho(5')adenosine, adenosine(5')diphospho(5')adenosine, ADP-ribose and NADH. (187 aa) |
