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coaD coaD spoT spoT gmk gmk lsrF lsrF XNC1_4239 XNC1_4239 accA-2 accA-2 pgi pgi glk glk XNC1_3486 XNC1_3486 ndk ndk purL purL accD accD purF purF pgk pgk XNC1_2968 XNC1_2968 ackA ackA pta pta purB purB fbaB fbaB purN purN purM purM purC purC purU purU yciA yciA purA-2 purA-2 pykA pykA XNC1_2118 XNC1_2118 guaA guaA XNC1_1907 XNC1_1907 pykF pykF XNC1_1767 XNC1_1767 XNC1_1758 XNC1_1758 fliI fliI XNC1_1438 XNC1_1438 gpmA gpmA sucB sucB ybeX ybeX gpt gpt aceF aceF aceE aceE coaE coaE XNC1_1004 XNC1_1004 tesB tesB apt apt adk adk purK purK purE purE hpt hpt relA relA eno eno accC accC ytjC ytjC purH purH purD purD purA purA cyaA cyaA gpp gpp coaA coaA tpiA tpiA dfp dfp pfkA pfkA acs acs atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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coaDCMP-deoxy-D-manno-octulosonate-lipid A transferase (phosphopantetheine adenylyltransferase); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa)
spoTBifunctional: (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (704 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (207 aa)
lsrFPutative aldolase with ribulose-phoshate binding barrel; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (294 aa)
XNC1_4239Putative phosphoribosylglycinamide formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (201 aa)
accA-2acetylCoA carboxylase, carboxytransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
pgiGlucosephosphate isomerase; Belongs to the GPI family. (548 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (322 aa)
XNC1_3486Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (421 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (142 aa)
purLPhosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
accDacetylCoA carboxylase, carboxyltranferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (315 aa)
purFAmidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (388 aa)
XNC1_2968Conserved hypothetical protein. (384 aa)
ackAAcetate kinase A (propionate kinase 2); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ptaPhosphotransacetylase (phosphate acetyltransferase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (688 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
fbaBFructose-bisphosphate aldolase class I. (349 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purMPhosphoribosylaminoimidazole synthetase (AIR synthetase). (347 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase). (237 aa)
purUFormyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa)
yciAPutative enzyme with thioesterase/thiol ester dehydrase-isomerase domain. (144 aa)
purA-2Adenylosuccinate synthetase 1 (IMP--aspartate ligase 1) (AdSS 1) (AMPSase 1); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (420 aa)
pykAPyruvate kinase II, glucose-stimulated; Belongs to the pyruvate kinase family. (480 aa)
XNC1_2118Putative Thiamine-phosphate kinase. (332 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa)
XNC1_1907Predicted kinase from adenilate kinase family, FLAR-like protein. (198 aa)
pykFPyruvate kinase I (formerly F), fructose-stimulated. (469 aa)
XNC1_1767Putative polyketide biosynthesis protein pksG. (411 aa)
XNC1_1758Putative Pyruvate dehydrogenase (acetyl-transferring). (664 aa)
fliIFlagellum-specific ATP synthase. (458 aa)
XNC1_1438Var1. (121 aa)
gpmAPhosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
sucBDihydrolipoyltranssuccinate transferase, component of the 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa)
ybeXPutative integral membrane protein with CBS regulatory domain. (292 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (153 aa)
aceFPyruvate dehydrogenase, dihydrolipoyltransacetylase subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (519 aa)
aceEPyruvate dehydrogenase, decarboxylase subunit, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (206 aa)
XNC1_1004Similar to Biotin carboxylase; Function of strongly homologous gene; enzyme. (453 aa)
tesBacyl-CoA thioesterase II. (284 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
purKPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
purEPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (188 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
relA(p)ppGpp synthetase I (GTP pyrophosphokinase); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (745 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (433 aa)
accCAcetyl CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
ytjCPutative phosphoglyceromutase 2; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
purHBifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal). (529 aa)
purDPhosphoribosylglycinamide synthetase (GAR synthetase); Belongs to the GARS family. (427 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
cyaAAdenylate cyclase; Belongs to the adenylyl cyclase class-1 family. (840 aa)
gppGuanosine pentaphosphatase, also has exopolyphosphatase activity; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. (503 aa)
coaAPantothenate kinase. (316 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
dfpBifunctional: 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (409 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (325 aa)
acsacetyl-CoA synthetase, has propionyl-CoA synthetase activity; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compo [...] (651 aa)
atpBMembrane-bound ATP synthase, F0 sector, subunit a, important for FO assembly; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (274 aa)
atpEMembrane-bound ATP synthase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (78 aa)
atpFMembrane-bound ATP synthase, F0 sector, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpHMembrane-bound ATP synthase, F1 sector, delta-subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (177 aa)
atpAMembrane-bound ATP synthase, F1 sector, alpha-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (513 aa)
atpGMembrane-bound ATP synthase, F1 sector, gamma-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa)
atpDMembrane-bound ATP synthase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (460 aa)
atpCMembrane-bound ATP synthase, F1 sector, epsilon-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa)
Your Current Organism:
Xenorhabdus nematophila
NCBI taxonomy Id: 406817
Other names: X. nematophila ATCC 19061, Xenorhabdus nematophila ATCC 19061, Xenorhabdus nematophila str. ATCC 19061, Xenorhabdus nematophila strain ATCC 19061
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