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purC purC purM purM purN purN purB purB XNC1_2968 XNC1_2968 purF purF purL purL XNC1_4239 XNC1_4239 purH purH purD purD purA purA purK purK purE purE hpt hpt adk adk apt apt gpt gpt ybeX ybeX XNC1_1907 XNC1_1907 guaA guaA XNC1_2118 XNC1_2118 purA-2 purA-2 add add purU purU
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purCPhosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase). (237 aa)
purMPhosphoribosylaminoimidazole synthetase (AIR synthetase). (347 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
XNC1_2968Conserved hypothetical protein. (384 aa)
purFAmidophosphoribosyltransferase (PRPP amidotransferase); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (505 aa)
purLPhosphoribosylformyl-glycineamide synthetase (FGAM synthetase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1295 aa)
XNC1_4239Putative phosphoribosylglycinamide formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (201 aa)
purHBifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal). (529 aa)
purDPhosphoribosylglycinamide synthetase (GAR synthetase); Belongs to the GARS family. (427 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
purKPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (355 aa)
purEPhosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (188 aa)
hptHypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (183 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (153 aa)
ybeXPutative integral membrane protein with CBS regulatory domain. (292 aa)
XNC1_1907Predicted kinase from adenilate kinase family, FLAR-like protein. (198 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa)
XNC1_2118Putative Thiamine-phosphate kinase. (332 aa)
purA-2Adenylosuccinate synthetase 1 (IMP--aspartate ligase 1) (AdSS 1) (AMPSase 1); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (420 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (333 aa)
purUFormyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (282 aa)
Your Current Organism:
Xenorhabdus nematophila
NCBI taxonomy Id: 406817
Other names: X. nematophila ATCC 19061, Xenorhabdus nematophila ATCC 19061, Xenorhabdus nematophila str. ATCC 19061, Xenorhabdus nematophila strain ATCC 19061
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