STRINGSTRING
ACZ32532.1 ACZ32532.1 lpxA lpxA fabZ fabZ lpxC lpxC lnt lnt ACZ32538.1 ACZ32538.1 ACZ32540.1 ACZ32540.1 ACZ32542.1 ACZ32542.1 kdsA kdsA ACZ32625.1 ACZ32625.1 ACZ32642.1 ACZ32642.1 fabF fabF cysQ cysQ ACZ32809.1 ACZ32809.1 aas aas lpxB lpxB accD accD kdtA kdtA accC accC accB accB kdsB kdsB acpP acpP fabG fabG fabD fabD fabH fabH lpxD lpxD acpS acpS fabI fabI ACZ33388.1 ACZ33388.1 accA accA ACZ33391.1 ACZ33391.1 hup hup ACZ33502.1 ACZ33502.1 lpxK lpxK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACZ32532.1Conserved hypothetical protein. (333 aa)
lpxAacyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (283 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (153 aa)
lpxCUDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (282 aa)
lntApolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (541 aa)
ACZ32538.1Thioesterase family protein; Belongs to the acyl coenzyme A hydrolase family. (155 aa)
ACZ32540.1Hypothetical protein. (41 aa)
ACZ32542.1Conserved hypothetical protein; Belongs to the chlamydial CPn_0658/CT_538/TC_0825 family. (238 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (269 aa)
ACZ32625.1Transporter, major facilitator family. (565 aa)
ACZ32642.1Conserved hypothetical protein. (282 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (416 aa)
cysQInositol monophosphatase family protein. (325 aa)
ACZ32809.1Acyltransferase family protein. (253 aa)
aasAMP-binding protein. (538 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (604 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (308 aa)
kdtA3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Thus generates the genus-specific LPS epitope of Chlamydia, composed of the trisaccharide alpha-Kdo-(2->8)-alpha-Kdo- (2->4)-alpha-Kdo; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily. (437 aa)
accCacetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
accBacetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (167 aa)
kdsB3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa)
fabG3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
fabDMalonyl CoA-acyl carrier protein transacylase. (308 aa)
fabH3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (335 aa)
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (360 aa)
acpSHolo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (122 aa)
fabIPutative enoyl-(acyl-carrier-protein) reductase. (299 aa)
ACZ33388.1ABC transporter, permease/ATP-binding protein. (659 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (324 aa)
ACZ33391.1Conserved hypothetical protein. (391 aa)
hupDNA-binding protein HU; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (100 aa)
ACZ33502.1Sugar isomerase, KpsF/GutQ family; Belongs to the SIS family. GutQ/KpsF subfamily. (329 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (365 aa)
Your Current Organism:
Chlamydia pneumoniae
NCBI taxonomy Id: 406984
Other names: C. pneumoniae LPCoLN, Chlamydia pneumoniae LPCoLN, Chlamydophila pneumoniae LPCoLN, Chlamydophila pneumoniae str. LPCoLN, Chlamydophila pneumoniae strain LPCoLN
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